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Exploring mitochondrial cholesterol (mChol) signalling for therapeutic intervention in neurological conditions

Desai, R; Campanella, M

Authors

R Desai

M Campanella



Abstract

The pharmacological targeting of cholesterol levels continues to draw interest due to the vast success of therapeutics such as statins in extending life expectancy by modifying the prognosis of diseases associated with the impairment of the lipid metabolism. Advances in our understanding of mitochondrial dysfunction in chronic age‐related diseases of the brain have unveiled an emerging role for mitochondrial cholesterol (mChol) in their pathophysiology, thus delineating an opportunity to provide mechanistic insights and explore strategies of intervention. This review draws attention to novel signalling mechanisms in conditions linked with impaired metabolism associated with impaired handling of cholesterol and its oxided forms (oxysterols) by mitochondria. By emphasising the role of mChol in neurological diseases we here call for novel approaches as well as new means of assessment.

Citation

Desai, R., & Campanella, M. (2019). Exploring mitochondrial cholesterol (mChol) signalling for therapeutic intervention in neurological conditions. British Journal of Pharmacology, https://doi.org/10.1111/bph.14697

Journal Article Type Review
Acceptance Date Mar 10, 2019
Publication Date May 11, 2019
Deposit Date May 25, 2019
Publicly Available Date Mar 28, 2024
Journal BRITISH JOURNAL OF PHARMACOLOGY
Print ISSN 0007-1188
Publisher Wiley
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1111/bph.14697
Public URL https://rvc-repository.worktribe.com/output/1382364

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