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Zebrafish as a model for kidney function and disease

Outtandy, P; Russell, C; Kleta, R; Brockenhauer, D

Authors

P Outtandy

C Russell

R Kleta

D Brockenhauer



Abstract

Kidney disease is a global problem with around three million people diagnosed in the UK alone and the incidence is rising. Research is critical to develop better treatments. Animal models can help to better understand the pathophysiology behind the various kidney diseases and to screen for therapeutic compounds, but the use especially of mammalian models should be minimised in the interest of animal welfare. Zebrafish are increasingly used, as they are genetically tractable and have a basic renal anatomy comparable to mammalian kidneys with glomerular filtration and tubular filtration processing. Here, we discuss how zebrafish have advanced the study of nephrology and the mechanisms underlying kidney disease.

Citation

Outtandy, P., Russell, C., Kleta, R., & Brockenhauer, D. (2019). Zebrafish as a model for kidney function and disease. Pediatric Nephrology, 34(5), 751-762. https://doi.org/10.1007/s00467-018-3921-7

Journal Article Type Article
Acceptance Date Dec 12, 2017
Publication Date May 1, 2019
Deposit Date Apr 4, 2019
Publicly Available Date Apr 5, 2019
Journal Pediatric Nephrology
Print ISSN 0931-041X
Publisher Springer
Peer Reviewed Peer Reviewed
Volume 34
Issue 5
Pages 751-762
DOI https://doi.org/10.1007/s00467-018-3921-7
Public URL https://rvc-repository.worktribe.com/output/1382562

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