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FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression

Ikpegbu, E; Basta, L; Clements, D N; Fleming, R; Vincent, T L; Buttle, D J; Pitsillides, A A; Staines, K A; Farquharson, C


E Ikpegbu

L Basta

D N Clements

R Fleming

T L Vincent

D J Buttle

A A Pitsillides

K A Staines

C Farquharson


E11/podoplanin is critical in the early stages of osteoblast-to-osteocyte transitions (osteocytogenesis), however, the upstream events which regulate E11 expression are unknown. The aim of this study was to examine the effects of FGF-2 on E11-mediated osteocytogenesis and to reveal the nature of the underlying signaling pathways regulating this process. Exposure of MC3T3 osteoblast-like cells and murine primary osteoblasts to FGF-2 (10ng/ml) increased E11 mRNA and protein expression (p


Ikpegbu, E., Basta, L., Clements, D. N., Fleming, R., Vincent, T. L., Buttle, D. J., …Farquharson, C. (2018). FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression. Journal of Cellular Physiology, 233(7), 5334-5347.

Journal Article Type Article
Acceptance Date Nov 29, 2017
Publication Date Jan 23, 2018
Deposit Date Jan 25, 2018
Publicly Available Date Jan 25, 2018
Journal Journal of Cellular Physiology
Print ISSN 0021-9541
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 233
Issue 7
Pages 5334-5347
Public URL


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