FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression

Ikpegbu, E; Basta, L; Clements, D N; Fleming, R; Vincent, T L; Buttle, D J; Pitsillides, A A; Staines, K A; Farquharson, C

Abstract

E11/podoplanin is critical in the early stages of osteoblast-to-osteocyte transitions (osteocytogenesis), however, the upstream events which regulate E11 expression are unknown. The aim of this study was to examine the effects of FGF-2 on E11-mediated osteocytogenesis and to reveal the nature of the underlying signaling pathways regulating this process. Exposure of MC3T3 osteoblast-like cells and murine primary osteoblasts to FGF-2 (10ng/ml) increased E11 mRNA and protein expression (p

Citation

Ikpegbu, E., Basta, L., Clements, D. N., Fleming, R., Vincent, T. L., Buttle, D. J., Pitsillides, A. A., Staines, K. A., & Farquharson, C. (2018). FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression. Journal of Cellular Physiology, 233(7), 5334-5347. https://doi.org/10.1002/jcp.26345

• Journal Article Type: Article
• Acceptance Date: Nov 29, 2017
• Publication Date: Jan 23, 2018
• Deposit Date: Jan 25, 2018
• Publicly Available Date: Jan 25, 2018
• Journal: Journal of Cellular Physiology
• Print ISSN: 0021-9541
• Electronic ISSN: 1097-4652
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 233
• Issue: 7
• Pages: 5334-5347
• DOI: https://doi.org/10.1002/jcp.26345
• Public URL: https://rvc-repository.worktribe.com/output/1389143