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Mitochondrial calcium imbalance in Parkinson's disease

Ludtmann, M H R; Abramov, A Y

Authors

M H R Ludtmann

A Y Abramov



Abstract

Multiple factors are involved in the mechanism(s) of neuronal loss in neurodegenerative disorders whilst mitochondria are thought to play a central role in neurodegeneration of Parkinson’s disease. Mitochondria are vital to cellular functions by supplying energy in form of ATP and affect cell physiology via calcium, ROS and signalling proteins. Changes in mitochondrial calcium homeostasis and ROS overproduction can induce cell death by triggering mitochondrial permeability transition pore opening. One of the major triggers for PTP is mitochondrial calcium overload. Mitochondrial Ca2+ homeostasis is regulated by electrogenic calcium uptake (via Ca2+ uniporter MCU) and efflux (in excitable cells via Na+/Ca2+ exchanger NCLX). NCLX inhibition has been described in a familial form of Parkinson’s disease where PINK-1 deficiency leads to a delayed calcium efflux and mitochondrial Ca2+ overload in response to physiological Ca2+ stimulation. Overexpression of NCLX in PINK-1 deficient neurons not only protects against mitochondrial calcium overload and calcium induced cell death but also restores mitochondrial bioenergetics in these neurons. Mitochondrial NCLX might therefore play an important role in the mechanism(s) of neurodegeneration in a variety of neurodegenerative disorders and activation of this exchanger may offer a novel therapeutic target.

Citation

Ludtmann, M. H. R., & Abramov, A. Y. (2018). Mitochondrial calcium imbalance in Parkinson's disease. Neuroscience Letters, 663, 8690. https://doi.org/10.1016/j.neulet.2017.08.044

Journal Article Type Article
Acceptance Date Aug 16, 2017
Publication Date Jan 10, 2018
Deposit Date Jun 28, 2018
Publicly Available Date Mar 28, 2024
Journal Neuroscience Letters
Print ISSN 0304-3940
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 663
Pages 8690
DOI https://doi.org/10.1016/j.neulet.2017.08.044
Public URL https://rvc-repository.worktribe.com/output/1389289

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