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Systematic review of studies generating individual participant data on the efficacy of drugs for treating soil-transmitted helminthiases and the case for data-sharing

Halder, J B; Benton, J; Julé, A M; Guérin, P J; Olliaro, P L; Basáñez, M-G; Walker, M

Authors

J B Halder

J Benton

A M Julé

P J Guérin

P L Olliaro

M-G Basáñez

M Walker



Abstract

Preventive chemotherapy and transmission control (PCT) by mass drug administration is the cornerstone of the World Health Organization (WHO)’s policy to control soil-transmitted helminthiases (STHs) caused by Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm) and hookworm species (Necator americanus and Ancylostama duodenale) which affect over 1 billion people globally. Despite consensus that drug efficacies should be monitored for signs of decline that could jeopardise the effectiveness of PCT, systematic monitoring and evaluation is seldom implemented. Drug trials mostly report aggregate efficacies in groups of participants, but heterogeneities in design complicate classical meta-analyses of these data. Individual participant data (IPD) permit more detailed analysis of drug efficacies, offering increased sensitivity to identify atypical responses potentially caused by emerging drug resistance.

Citation

Halder, J. B., Benton, J., Julé, A. M., Guérin, P. J., Olliaro, P. L., Basáñez, M., & Walker, M. (2017). Systematic review of studies generating individual participant data on the efficacy of drugs for treating soil-transmitted helminthiases and the case for data-sharing. PLoS Neglected Tropical Diseases, 11(10), e0006053. https://doi.org/10.1371/journal.pntd.0006053

Journal Article Type Review
Acceptance Date Oct 19, 2017
Publication Date Oct 31, 2017
Deposit Date Nov 22, 2017
Publicly Available Date Mar 28, 2024
Journal PLoS Neglected Tropical Diseases
Print ISSN 1935-2727
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 11
Issue 10
Pages e0006053
DOI https://doi.org/10.1371/journal.pntd.0006053
Public URL https://rvc-repository.worktribe.com/output/1390191

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