Systematic review of studies generating individual participant data on the efficacy of drugs for treating soil-transmitted helminthiases and the case for data-sharing

Halder, J B; Benton, J; Julé, A M; Guérin, P J; Olliaro, P L; Basáñez, M-G; Walker, M

doi:10.1371/journal.pntd.0006053

Systematic review of studies generating individual participant data on the efficacy of drugs for treating soil-transmitted helminthiases and the case for data-sharing

Halder, J B; Benton, J; Julé, A M; Guérin, P J; Olliaro, P L; Basáñez, M-G; Walker, M

Authors

J B Halder

J Benton

A M Julé

P J Guérin

P L Olliaro

M-G Basáñez

M Walker

Abstract

Preventive chemotherapy and transmission control (PCT) by mass drug administration is the cornerstone of the World Health Organization (WHO)’s policy to control soil-transmitted helminthiases (STHs) caused by Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm) and hookworm species (Necator americanus and Ancylostama duodenale) which affect over 1 billion people globally. Despite consensus that drug efficacies should be monitored for signs of decline that could jeopardise the effectiveness of PCT, systematic monitoring and evaluation is seldom implemented. Drug trials mostly report aggregate efficacies in groups of participants, but heterogeneities in design complicate classical meta-analyses of these data. Individual participant data (IPD) permit more detailed analysis of drug efficacies, offering increased sensitivity to identify atypical responses potentially caused by emerging drug resistance.

Citation

Halder, J. B., Benton, J., Julé, A. M., Guérin, P. J., Olliaro, P. L., Basáñez, M.-G., & Walker, M. (2017). Systematic review of studies generating individual participant data on the efficacy of drugs for treating soil-transmitted helminthiases and the case for data-sharing. PLoS Neglected Tropical Diseases, 11(10), e0006053. https://doi.org/10.1371/journal.pntd.0006053

Journal Article Type	Review
Acceptance Date	Oct 19, 2017
Publication Date	Oct 31, 2017
Deposit Date	Nov 22, 2017
Publicly Available Date	Nov 22, 2017
Journal	PLoS Neglected Tropical Diseases
Print ISSN	1935-2727
Electronic ISSN	1935-2735
Publisher	Public Library of Science
Peer Reviewed	Peer Reviewed
Volume	11
Issue	10
Pages	e0006053
DOI	https://doi.org/10.1371/journal.pntd.0006053
Public URL	https://rvc-repository.worktribe.com/output/1390191