Systematic review of studies generating individual participant data on the efficacy of drugs for treating soil-transmitted helminthiases and the case for data-sharing

Halder, J B; Benton, J; Julé, A M; Guérin, P J; Olliaro, P L; Basáñez, M-G; Walker, M

Abstract

Preventive chemotherapy and transmission control (PCT) by mass drug administration is the cornerstone of the World Health Organization (WHO)’s policy to control soil-transmitted helminthiases (STHs) caused by Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm) and hookworm species (Necator americanus and Ancylostama duodenale) which affect over 1 billion people globally. Despite consensus that drug efficacies should be monitored for signs of decline that could jeopardise the effectiveness of PCT, systematic monitoring and evaluation is seldom implemented. Drug trials mostly report aggregate efficacies in groups of participants, but heterogeneities in design complicate classical meta-analyses of these data. Individual participant data (IPD) permit more detailed analysis of drug efficacies, offering increased sensitivity to identify atypical responses potentially caused by emerging drug resistance.

Citation

Halder, J. B., Benton, J., Julé, A. M., Guérin, P. J., Olliaro, P. L., Basáñez, M., & Walker, M. (2017). Systematic review of studies generating individual participant data on the efficacy of drugs for treating soil-transmitted helminthiases and the case for data-sharing. PLoS Neglected Tropical Diseases, 11(10), e0006053. https://doi.org/10.1371/journal.pntd.0006053

• Journal Article Type: Review
• Acceptance Date: Oct 19, 2017
• Publication Date: Oct 31, 2017
• Deposit Date: Nov 22, 2017
• Publicly Available Date: Nov 21, 2020
• Journal: PLoS Neglected Tropical Diseases
• Print ISSN: 1935-2727
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 10
• Pages: e0006053
• DOI: https://doi.org/10.1371/journal.pntd.0006053
• Public URL: https://rvc-repository.worktribe.com/output/1390191