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Dogs with macroadenomas have lower body temperature and heart rate than dogs with microadenomas

Benchekroun, G; Desquilbet, L; Herrtage, M E; Jeffery, N D; Rosenberg, D; Granger, N


G Benchekroun

L Desquilbet

M E Herrtage

N D Jeffery

D Rosenberg

N Granger


Pituitary macroadenomas compress the hypothalamus, which partly regulates heart rate and body temperature. The aim of this study was to investigate whether heart rate and/or body temperature could aid in clinically differentiating dogs with macroadenomas from dogs with microadenomas (i.e. small non-compressive pituitary mass). Two groups of dogs diagnosed with pituitary-dependent hyperadrenocorticism (i.e. Cushing’s disease) were included. Heart rate and body temperature were collected on initial presentation before any procedure. Dogs with macroadenoma had a significantly lower heart rate and body temperature (P < 0.01) compared to dogs with microadenoma. We suggest that the combined cut-off values of 84 beats per minutes and 38.3 °C in dogs with Cushing’s disease, especially with vague neurological signs (nine of 12 dogs = 75%), might help to suspect the presence of a macroadenoma.


Benchekroun, G., Desquilbet, L., Herrtage, M. E., Jeffery, N. D., Rosenberg, D., & Granger, N. (2017). Dogs with macroadenomas have lower body temperature and heart rate than dogs with microadenomas. The Veterinary Journal, 227, 42-45.

Journal Article Type Other
Acceptance Date Aug 23, 2017
Publication Date Sep 6, 2017
Deposit Date Sep 1, 2017
Publicly Available Date Sep 1, 2018
Print ISSN 1090-0233
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 227
Pages 42-45
Public URL


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