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A Possible Case of Neurogenic Pulmonary Edema in a Sheep following Intracranial Surgery

Casoni, D; Giovannini, A E J; Precht, C M; Adami, C


D Casoni

A E J Giovannini

C M Precht

C Adami


A 3-year-old female crossbred sheep weighing 64 kg was anaesthetized for intracranial surgery as a part of a research project. Premedication and induction of anesthesia were uneventful as well as tracheal intubation. Anesthesia was maintained with isoflurane in a 50% mixture of oxygen and air, fentanyl (5-15 µg kg-1h-1) and lidocaine (1.8 mg kg-1h-1). During anesthesia, an increased alveolar-arterial oxygen gradient was calculated on the basis of arterial blood gas analysis: inspiratory fraction of oxygen was increased and a recruitment manoeuvre was performed. After 210 minutes of anesthesia, the sheep was let recover with oxygen supplementation under monitoring of pulse-oxymetry, capnography, inspired and expired oxygen, temperature and invasive blood pressure. At tracheal extubation no signs of regurgitation or aspiration were noticed. Twenty-five minutes later, the sheep showed deterioration of neurological status and clonic seizure responsive to diazepam. After transient tachycardia, blood pressure rose acutely and sinus bradycardia followed. Severe tachypnea started in few minutes accompanied by loud respiratory noises and harsh diffuse crackles on both sides of the thorax. Foamy blood nasal exudates discharged from the nostrils. Neurogenic pulmonary edema as a sequel of increased intracranial pressure was suspected and treated with intravenous mannitol (0.5 gkg-1) and furosemide (4 mgKg-1). Hypoxemia was successfully managed with oxygen supplementation. Motor and cognitive functions improved progressively and were deemed normal within 12 hours from the episode, when arterial partial pressure of oxygen was 11.7 kPa (88 mmHg) at room air.


Casoni, D., Giovannini, A. E. J., Precht, C. M., & Adami, C. (2016). A Possible Case of Neurogenic Pulmonary Edema in a Sheep following Intracranial Surgery.

Journal Article Type Other
Acceptance Date Apr 19, 2016
Publication Date Apr 23, 2016
Deposit Date May 12, 2018
Publicly Available Date May 14, 2018
Journal Journal of Clinical Anesthesia and Management
Peer Reviewed Peer Reviewed
Volume 1
Issue 3
Public URL


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