Prenatal muscle development in a mouse model for the secondary dystroglycanopathies
Kim, J; Hopkinson, M; Kavishwar, M; Fernandez-Fuente, M; Brown, S C
S C Brown
The defective glycosylation of ?-dystroglycan is associated with a group of muscular dystrophies that are collectively referred to as the secondary dystroglycanopathies. Mutations in the gene encoding fukutin-related protein (FKRP) are one of the most common causes of secondary dystroglycanopathy in the UK and are associated with a wide spectrum of disease. Whilst central nervous system involvement has a prenatal onset, no studies have addressed prenatal muscle development in any of the mouse models for this group of diseases. In view of the pivotal role of ?-dystroglycan in early basement membrane formation, we sought to determine if the muscle formation was altered in a mouse model of FKRP-related dystrophy.
Kim, J., Hopkinson, M., Kavishwar, M., Fernandez-Fuente, M., & Brown, S. C. (2016). Prenatal muscle development in a mouse model for the secondary dystroglycanopathies. Skeletal Muscle, 6(3), https://doi.org/10.1186/s13395-016-0073-y
|Journal Article Type||Article|
|Acceptance Date||Jan 5, 2016|
|Publication Date||Feb 19, 2016|
|Deposit Date||Feb 20, 2016|
|Publicly Available Date||Nov 21, 2020|
|Peer Reviewed||Peer Reviewed|
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