The genomic basis of parasitism in the Strongyloides clade of nematodes

Hunt, V L; Tsai, I J; Coghlan, A; Reid, A J; Holroyd, N; Foth, B J; Tracey, A; Cotton, J A; Stanley, E J; Beasley, H; Bennett, H M; Brooks, K; Harsha, B; Kajitani, R; Kulkarni, A; Harbecke, D; Nagayasu, E; Nichol, S; Ogura, Y; Quail, M A; Randle, N; Xia, D; Brattig, N W; Soblik, H; Ribeiro, D M; Sanchez-Flores, A; Hayashi, T; Itoh, T; Denver, D R; Grant, W; Stoltzfus, J D; Lok, J B; Murayama, H; Wastling, J; Streit, A; Kikuchi, T; Viney, M; Berriman, M

doi:10.1038/ng.3495

The genomic basis of parasitism in the Strongyloides clade of nematodes

Hunt, V L; Tsai, I J; Coghlan, A; Reid, A J; Holroyd, N; Foth, B J; Tracey, A; Cotton, J A; Stanley, E J; Beasley, H; Bennett, H M; Brooks, K; Harsha, B; Kajitani, R; Kulkarni, A; Harbecke, D; Nagayasu, E; Nichol, S; Ogura, Y; Quail, M A; Randle, N; Xia, D; Brattig, N W; Soblik, H; Ribeiro, D M; Sanchez-Flores, A; Hayashi, T; Itoh, T; Denver, D R; Grant, W; Stoltzfus, J D; Lok, J B; Murayama, H; Wastling, J; Streit, A; Kikuchi, T; Viney, M; Berriman, M

Authors

V L Hunt

I J Tsai

A Coghlan

A J Reid

N Holroyd

B J Foth

A Tracey

J A Cotton

E J Stanley

H Beasley

H M Bennett

K Brooks

B Harsha

R Kajitani

A Kulkarni

D Harbecke

E Nagayasu

S Nichol

Y Ogura

M A Quail

N Randle

D Xia

N W Brattig

H Soblik

D M Ribeiro

A Sanchez-Flores

T Hayashi

T Itoh

D R Denver

W Grant

J D Stoltzfus

J B Lok

H Murayama

J Wastling

A Streit

T Kikuchi

M Viney

M Berriman

Abstract

Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichosuri) and free-living (Rhabditophanes sp. KR3021). A significant paralogous expansion of key gene families—families encoding astacin-like and SCP/TAPS proteins—is associated with the evolution of parasitism in this clade. Exploiting the unique Strongyloides life cycle, we compare the transcriptomes of the parasitic and free-living stages and find that these same gene families are upregulated in the parasitic stages, underscoring their role in nematode parasitism.

Citation

Hunt, V. L., Tsai, I. J., Coghlan, A., Reid, A. J., Holroyd, N., Foth, B. J., …Berriman, M. (2016). The genomic basis of parasitism in the Strongyloides clade of nematodes. Nature Genetics, 48(3), 299-307. https://doi.org/10.1038/ng.3495

Journal Article Type	Article
Acceptance Date	Dec 23, 2015
Publication Date	Feb 1, 2016
Deposit Date	Aug 17, 2018
Publicly Available Date	Nov 21, 2020
Journal	Nature Genetics
Print ISSN	1061-4036
Publisher	Nature Research
Peer Reviewed	Peer Reviewed
Volume	48
Issue	3
Pages	299-307
DOI	https://doi.org/10.1038/ng.3495
Public URL	https://rvc-repository.worktribe.com/output/1397775