Skip to main content

Research Repository

Advanced Search

The genomic basis of parasitism in the Strongyloides clade of nematodes

Hunt, V L; Tsai, I J; Coghlan, A; Reid, A J; Holroyd, N; Foth, B J; Tracey, A; Cotton, J A; Stanley, E J; Beasley, H; Bennett, H M; Brooks, K; Harsha, B; Kajitani, R; Kulkarni, A; Harbecke, D; Nagayasu, E; Nichol, S; Ogura, Y; Quail, M A; Randle, N; Xia, D; Brattig, N W; Soblik, H; Ribeiro, D M; Sanchez-Flores, A; Hayashi, T; Itoh, T; Denver, D R; Grant, W; Stoltzfus, J D; Lok, J B; Murayama, H; Wastling, J; Streit, A; Kikuchi, T; Viney, M; Berriman, M


V L Hunt

I J Tsai

A Coghlan

A J Reid

N Holroyd

B J Foth

A Tracey

J A Cotton

E J Stanley

H Beasley

H M Bennett

K Brooks

B Harsha

R Kajitani

A Kulkarni

D Harbecke

E Nagayasu

S Nichol

Y Ogura

M A Quail

N Randle

D Xia

N W Brattig

H Soblik

D M Ribeiro

A Sanchez-Flores

T Hayashi

T Itoh

D R Denver

W Grant

J D Stoltzfus

J B Lok

H Murayama

J Wastling

A Streit

T Kikuchi

M Viney

M Berriman


Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichosuri) and free-living (Rhabditophanes sp. KR3021). A significant paralogous expansion of key gene families—families encoding astacin-like and SCP/TAPS proteins—is associated with the evolution of parasitism in this clade. Exploiting the unique Strongyloides life cycle, we compare the transcriptomes of the parasitic and free-living stages and find that these same gene families are upregulated in the parasitic stages, underscoring their role in nematode parasitism.


Hunt, V. L., Tsai, I. J., Coghlan, A., Reid, A. J., Holroyd, N., Foth, B. J., …Berriman, M. (2016). The genomic basis of parasitism in the Strongyloides clade of nematodes. Nature Genetics, 48(3), 299-307.

Journal Article Type Article
Acceptance Date Dec 23, 2015
Publication Date Feb 1, 2016
Deposit Date Aug 17, 2018
Publicly Available Date Aug 17, 2018
Journal Nature Genetics
Print ISSN 1061-4036
Publisher Nature Research
Peer Reviewed Peer Reviewed
Volume 48
Issue 3
Pages 299-307
Public URL


You might also like

Downloadable Citations