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TSPO is a REDOX regulator of cell mitophagy

Gatliff, J; Campanella, M

Authors

J Gatliff

M Campanella



Abstract

The mitochondrial 18-kDa translocator protein (TSPO) was originally discovered as a peripheral binding site of benzodiazepines to be later described as a core element of cholesterol trafficking between cytosol and mitochondria from which the current nomenclature originated. The high affinity it exhibits with chemicals (i.e. PK11195) has generated interest in the development of mitochondrial based TSPO-binding drugs for in vitro and in vivo analysis. Increased TSPO expression is observed in numerous pathologies such as cancer and inflammatory conditions of the central nervous system (CNS) that have been successfully exploited via protocols of positron emission tomography (PET) imaging. We endeavoured to dissect the molecular role of TSPO in mitochondrial cell biology and discovered a functional link with quality control mechanisms operated by selective autophagy. This review focuses on the current understanding of this pathway and focuses on the interplay with reactive oxygen species (ROS) and the voltage-dependent anion channel (VDAC), to which TSPO binds, in the regulation of cell mitophagy and hence homoeostasis of the mitochondrial network as a whole.

Citation

Gatliff, J., & Campanella, M. (in press). TSPO is a REDOX regulator of cell mitophagy. Biochemical Society Transactions, 43, 543-552. https://doi.org/10.1042/BST20150037

Journal Article Type Article
Acceptance Date Aug 1, 2015
Deposit Date Sep 10, 2015
Journal BIOCHEMICAL SOCIETY TRANSACTIONS
Print ISSN 0300-5127
Publisher Portland Press
Volume 43
Pages 543-552
DOI https://doi.org/10.1042/BST20150037
Public URL https://rvc-repository.worktribe.com/output/1400006



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