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International Veterinary Epilepsy Task Force recommendations for systematic sampling and processing of brains from epileptic dogs and cats

Matiasek, K; Pumarola Batlle, M; Rosati, M; Fernandez-Flores, F; Fischer, A; Wagner, E; Berendt, M; Bhatti, S F M; De Risio, L; Farquhar, R G; Long, S; Munana, K; Patterson, E E; Pakozdy, A; Penderis, J; Platt, S; Podell, M; Potschka, H; Rusbridge, C; Stein, V M; Tipold, A; Volk, H A

Authors

K Matiasek

M Pumarola Batlle

M Rosati

F Fernandez-Flores

A Fischer

E Wagner

M Berendt

S F M Bhatti

L De Risio

R G Farquhar

S Long

K Munana

E E Patterson

A Pakozdy

J Penderis

S Platt

M Podell

H Potschka

C Rusbridge

V M Stein

A Tipold

H A Volk



Abstract

Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities. For many instances, however, neuropathological studies fail to add substantial data on patients with complete clinical work-up. This may be due to sparse training in epilepsy pathology and or due to lack of neuropathological guidelines for companion animals.

The protocols introduced herein shall facilitate systematic sampling and processing of epileptic brains and therefore increase the efficacy, reliability and reproducibility of morphological studies in animals suffering from seizures.

Brain dissection protocols of two neuropathological centres with research focus in epilepsy have been optimised with regards to their diagnostic yield and accuracy, their practicability and their feasibility concerning clinical research requirements.

The recommended guidelines allow for easy, standardised and ubiquitous collection of brain regions, relevant for seizure generation. Tissues harvested the prescribed way will increase the diagnostic efficacy and provide reliable material for scientific investigations.

Citation

Matiasek, K., Pumarola Batlle, M., Rosati, M., Fernandez-Flores, F., Fischer, A., Wagner, E., …Volk, H. A. (in press). International Veterinary Epilepsy Task Force recommendations for systematic sampling and processing of brains from epileptic dogs and cats. BMC Veterinary Research, 11(216), https://doi.org/10.1186/s12917-015-0467-9

Journal Article Type Article
Acceptance Date Jun 29, 2015
Deposit Date Sep 3, 2015
Publicly Available Date Feb 25, 2019
Journal BMC Veterinary Research
Publisher BioMed Central
Peer Reviewed Peer Reviewed
Volume 11
Issue 216
DOI https://doi.org/10.1186/s12917-015-0467-9
Public URL https://rvc-repository.worktribe.com/output/1400406

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