Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure

Baker, L A; Lee, K C L; Jimenez, C P; Alibhai, H I K; Chang, Y M; Leckie, P J; Mookerjee, R P; Davies, N A; Andreola, F; Jalan, R

Abstract

Acute liver failure is a rare but catastrophic condition which can progress rapidly to multi-organ failure. Studies investigating the onset of individual organ injury such as the liver, kidneys and brain during the evolution of acute liver failure, are lacking. MicroRNAs are short, non-coding strands of RNA that are released into the circulation following tissue injury. In this study, we have characterised the release of both global microRNA and specific microRNA species into the plasma using a porcine model of acetaminophen-induced acute liver failure. Pigs were induced to acute liver failure with oral acetaminophen over 19h±2h and death occurred 13h±3h thereafter. Global microRNA concentrations increased 4h prior to acute liver failure in plasma (P

Citation

Baker, L. A., Lee, K. C. L., Jimenez, C. P., Alibhai, H. I. K., Chang, Y. M., Leckie, P. J., …Jalan, R. (2015). Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure. PLoS ONE, 10(5), https://doi.org/10.1371/journal.pone.0128076

• Journal Article Type: Article
• Acceptance Date: Apr 23, 2015
• Publication Date: May 27, 2015
• Deposit Date: Jul 8, 2015
• Publicly Available Date: Jul 8, 2015
• Journal: PLoS One
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 5
• DOI: https://doi.org/10.1371/journal.pone.0128076
• Public URL: https://rvc-repository.worktribe.com/output/1400730