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Controlled and Impaired Mitochondrial Quality in Neurons: Molecular Physiology and Prospective Pharmacology

Matic, I; Strobbe, D; Frison, M; Campanella, M

Authors

I Matic

D Strobbe

M Frison

M Campanella



Abstract

Tuned mitochondrial physiology is fundamental for qualitative cellular function. This is particularly relevant for neurons, whose pathology is frequently associated with mitochondrial deficiencies. Defects in mitochondria are indeed key features in most neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Huntington's Disease (HD) and Amyotrophic Lateral Sclerosis (ALS).

When mitochondrial coupling impairs, so does cell metabolism, trafficking and the signaling depending on the homeostasis of the mitochondrial network. Moreover, the quality control of mitochondria – via the process of mitochondrial autophagy – results biased in neurodegeneration stemming major interest on the molecular determinants of this process among neuroscientists.

In this review, we highlight the most notable and acknowledged deficiencies of mitochondrial function and their relationship with diseases occurring in neurons and their transmission.

The physiological aspects of mitochondrial biology in relation to bio-energy, dynamics and quality control will be discussed with the finality to form a comprehensive picture of the mitochondrial contribution to the pathophysiology of neurodegenerative syndromes. In this way we aim to set the scene to conceive novel strategies to better diagnose and target these debilitative conditions.

Citation

Matic, I., Strobbe, D., Frison, M., & Campanella, M. (in press). Controlled and Impaired Mitochondrial Quality in Neurons: Molecular Physiology and Prospective Pharmacology. Pharmacological Research, 99, 410-424. https://doi.org/10.1016/j.phrs.2015.03.021

Journal Article Type Article
Acceptance Date Mar 27, 2015
Deposit Date Aug 12, 2015
Journal Pharmacological Research
Print ISSN 1043-6618
Publisher Elsevier
Volume 99
Pages 410-424
DOI https://doi.org/10.1016/j.phrs.2015.03.021
Public URL https://rvc-repository.worktribe.com/output/1401458