J C Regan
An Fgf8-Dependent Bistable Cell Migratory Event Establishes CNS Asymmetry
Regan, J C; Concha, M L; Roussigne, M; Russell, C; Wilson, S W
Authors
M L Concha
M Roussigne
C Russell
S W Wilson
Abstract
Neuroanatomical and functional asymmetries are universal features of the vertebrate CNS, but how asymmetry is generated is unknown. Here we show that zebrafish fgf8 mutants do not elaborate forebrain asymmetries, demonstrated by the failure of the parapineal nucleus to migrate from its initial midline position to the left side of the brain. Local provision of Fgf8 restores the asymmetric migration of parapineal cells, usually to the left, irrespective of the location of the Fgf8 source. This laterality bias is due to left-sided Nodal signaling and when the bias in Nodal signaling is removed, parapineal cells migrate toward the source of Fgf8 protein. This study presents a mechanism for breaking neuroanatomical symmetry through Fgf8-dependent regulation of bistable left- or right-sided migration of the parapineal. The combined action of Fgf and Nodal signals ensures the establishment of neuroanatomical asymmetries with consistent laterality.
Citation
Regan, J. C., Concha, M. L., Roussigne, M., Russell, C., & Wilson, S. W. An Fgf8-Dependent Bistable Cell Migratory Event Establishes CNS Asymmetry. Neuron, 61(1), 27-34. https://doi.org/10.1016/j.neuron.2008.11.030
Journal Article Type | Article |
---|---|
Deposit Date | Nov 12, 2014 |
Journal | Neuron |
Print ISSN | 0896-6273 |
Publisher | Cell Press |
Volume | 61 |
Issue | 1 |
Pages | 27-34 |
DOI | https://doi.org/10.1016/j.neuron.2008.11.030 |
Public URL | https://rvc-repository.worktribe.com/output/1427244 |
Additional Information | Corporate Creators : Chile, UCL |
You might also like
A founder mutation in EHD1 presents with tubular proteinuria and deafness
(2022)
Journal Article
Does Providing Hiding Spaces for Zebrafish in Large Groups Reduce Aggressive Behaviour?
(2020)
Journal Article
Special edition: The NCLs/Batten disease
(2020)
Journal Article
The contribution of multicellular model organisms to Neuronal Ceroid Lipofuscinosis research
(2019)
Journal Article
Downloadable Citations
About RVC Repository
Administrator e-mail: publicationsrepos@rvc.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search