Mast cell morphometry and densitometry in experimental skin wounds treated with a gel containing adelmidrol: A placebo controlled study

Abramo, F; Salluzzi, D; Leotta, R; Auxilia, S; Noli, C; Miolo, A; Mantis, P; Lloyd, D H

Abstract

The role of skin mast cells (MCs) in wound healing has been extensively investigated. The present study was designed to examine the effect of the aliamide adelmidrol on MCs during healing of experimental cutaneous wounds. Adelmidrol gel or the vehicle alone was applied 3 times daily on 5-mm punch biopsy wounds created on the thoracolumbar skin of 10 dogs. Wounds were allowed to heal by secondary intention. Eight-mm punch samples of the healing wounds were taken on days 1, 2, 4, 8, and 14, for histology. Mast cell numbers were counted and granular content assessed by densitometric analysis on toluidine blue-stained sections. The overall mean granule content wounds, whereas no statistically significant differences in MC counts were observed. These data indicate a reduction in MC degranulation in wounds topically treated with adelmidrol suggesting that the compound is able to down-modulate skin MC releasability without affecting their number.

Citation

Abramo, F., Salluzzi, D., Leotta, R., Auxilia, S., Noli, C., Miolo, A., …Lloyd, D. H. Mast cell morphometry and densitometry in experimental skin wounds treated with a gel containing adelmidrol: A placebo controlled study

• Journal Article Type: Other
• Deposit Date: Nov 11, 2014
• Journal: WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
• Volume: 20
• Issue: 6
• Pages: 149-157
• Public URL: https://rvc-repository.worktribe.com/output/1428274
• Additional Information: Corporate Creators : Innovet Italia Srl, Osped Vet Cuneese, Pisa