Diagnosis of hyperthyroidism in cats with mild chronic kidney disease

Wakeling, J M; Moore, K; Elliott, J; Syme, H M

Abstract

OBJECTIVES: In cats with concurrent hyperthyroidism and non-thyroidal illnesses such as chronic kidney disease, total thyroxine concentrations are often within the laboratory reference range (19 to 55 nmol/l). The objective of the study was to determine total thyroxine, free thyroxine and/or thyroid-stimulating hormone concentrations in cats with mild chronic kidney disease. METHODS: Total thyroxine, free thyroxine and thyroid-stimulating hormone were measured in three groups. The hyperthyroidism-chronic kidney disease group (n=16) had chronic kidney disease and clinical signs compatible with hyperthyroidism but a plasma total thyroxine concentration within the reference range. These cats were subsequently confirmed to be hyperthyroid at a later date. The chronic kidney disease-only group (n=20) had chronic kidney disease but no signs of hyperthyroidism. The normal group (n=20) comprised clinically healthy senior (> 8 years) cats. RESULTS: In 4 of 20 euthyroid chronic kidney disease cats, free thyroxine concentrations were borderline or high (>= 40 pmol/l). In the hyperthyroidism-chronic kidney disease group, free thyroxine was high in 15 of 16 cats, while thyroid-stimulating hormone was low in 16 of 16 cats. Most hyperthyroidism-chronic kidney disease cats (14 of 16) had total thyroxine greater than 30 nmol/l, whereas all the chronic kidney disease-only cats had total thyroxine less than 30 nmol/l. CLINICAL SIGNIFICANCE: The combined measurement of free thyroxine with total thyroxine or thyroid-stimulating hormone may be of merit in the diagnosis of hyperthyroidism in cats with chronic kidney disease.

Citation

Wakeling, J. M., Moore, K., Elliott, J., & Syme, H. M. Diagnosis of hyperthyroidism in cats with mild chronic kidney disease. Journal of Small Animal Practice, 49(6), 287-294. https://doi.org/10.1111/j.1748-5827.2008.00544.x

• Journal Article Type: Article
• Deposit Date: Nov 12, 2014
• Journal: JOURNAL OF SMALL ANIMAL PRACTICE
• Print ISSN: 0022-4510
• Electronic ISSN: 1748-5827
• Publisher: Wiley
• Volume: 49
• Issue: 6
• Pages: 287-294
• DOI: https://doi.org/10.1111/j.1748-5827.2008.00544.x
• Public URL: https://rvc-repository.worktribe.com/output/1431415
• Additional Information: Corporate Creators : Black And Partners