Effect of topical antimicrobial therapy and household cleaning on meticillin-resistant Staphylococcus pseudintermedius carriage in dogs

Frosini, Sian Marie; Bond, Ross; King, Ruth; Feudi, Claudia; Schwarz, Stefan; Loeffler, Anette

Abstract

Abstract
MRSP is a multidrug-resistant, zoonotic canine pathogen. This study investigated MRSP carriage and clearance through topical antimicrobial therapy and household cleaning in dogs recovered from MRSP infection.
Dogs were swabbed for MRSP carriage; household contamination was assessed using contact plates. Carrier dogs were allocated randomly to receive topical fusidic acid and chlorhexidine/miconazole treatment combined with owners implementing a household hygiene protocol (H&T) or implementation of hygiene alone (H) over three weeks. Carriage-negative dogs were monitored monthly. Relatedness of isolates over time was investigated by PFGE.
At inclusion, MRSP carriage was confirmed in 31/46 (67.4%) index dogs, 16/24 (66.7%) contact dogs and contamination was found in 18/40 (45%) environments. In dogs completing all cycles, interventions cleared carriage in 5/9 (55.6%) dogs in group H&T and 2/6 (33.3%) in group H. Carriage frequency reduced with topical antimicrobial treatment and hygiene (P

Citation

Frosini, S. M., Bond, R., King, R., Feudi, C., Schwarz, S., & Loeffler, A. (2021). Effect of topical antimicrobial therapy and household cleaning on meticillin-resistant Staphylococcus pseudintermedius carriage in dogs. BMJ Open, https://doi.org/10.1002/vetr.937

• Journal Article Type: Article
• Acceptance Date: Aug 28, 2021
• Publication Date: Sep 27, 2021
• Deposit Date: Jan 28, 2021
• Publicly Available Date: Jul 15, 2022
• Journal: BMJ Open
• Electronic ISSN: 2044-6055
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1002/vetr.937