Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo

Mamais, Adamantios; Cookson, Mark R.; Lewis, Patrick A.; Manzoni, Claudia; Li, Yan; Mazza, Melissa Conti; Kluss, Jillian H.

doi:10.1186/s13024-021-00441-8

Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo

Mamais, Adamantios; Cookson, Mark R.; Lewis, Patrick A.; Manzoni, Claudia; Li, Yan; Mazza, Melissa Conti; Kluss, Jillian H.

Authors

Adamantios Mamais

Mark R. Cookson

Patrick A. Lewis

Claudia Manzoni

Yan Li

Melissa Conti Mazza

Jillian H. Kluss

Contributors

Patrick Lewis
Supervisor

Citation

Mamais, A., Cookson, M. R., Lewis, P. A., Manzoni, C., Li, Y., Mazza, M. C., & Kluss, J. H. (2021). Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo. Molecular Neurodegeneration, 16(1), https://doi.org/10.1186/s13024-021-00441-8

Journal Article Type	Article
Acceptance Date	Mar 4, 2021
Online Publication Date	Mar 19, 2021
Publication Date	2021-12
Deposit Date	Apr 16, 2021
Publicly Available Date	Apr 16, 2021
Journal	Molecular Neurodegeneration
Electronic ISSN	1750-1326
Publisher	BioMed Central
Peer Reviewed	Peer Reviewed
Volume	16
Issue	1
DOI	https://doi.org/10.1186/s13024-021-00441-8
Keywords	Molecular Biology; Cellular and Molecular Neuroscience; Clinical Neurology
Public URL	https://rvc-repository.worktribe.com/output/1548280
Additional Information	Received: 16 September 2020; Accepted: 4 March 2021; First Online: 19 March 2021; : ; : The authors declare that they have no competing interests.