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Randomized double?blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells

Radulescu, Sinziana Maria; Skulberg, Ragnhild; McDonald, Charlotte; Chan, Daniel L.; Humm, Karen

Authors

Sinziana Maria Radulescu

Ragnhild Skulberg

Charlotte McDonald

Daniel L. Chan

Karen Humm



Abstract

Abstract
Background: Leukoreduction of blood products is commonly performed in human
medicine, but its effect on outcome or incidence of transfusion reactions (TRs) in
dogs is unknown.
Objectives: To prospectively evaluate the incidence of acute TRs in, and the outcome
of, dogs receiving either leukoreduced (LR) or nonleukoreduced (N-LR) packed red
blood cells (PRBC).
Animals: Dogs (n = 194) administered PRBC between August 2017 and June 2020.
Methods: Prospective randomized double-blinded clinical trial. Dogs were randomized
to receive either LR or N-LR PRBC and clinicians, nurses and investigators were
blinded to the group allocations. The incidence of TRs, change in PCV, hospitalization
duration, and survival to discharge were recorded.
Results: Out of the 194 dogs, 96 received LR and 98 received N-LR PRBCs. The
mean 12-hour change in PCV value was +9.22% (SD 5.27%) for dogs that received
N-LR and +10.69% (SD 6.44%) for dogs that received LR PRBC (effect size 0.26,
95% confidence interval [CI] 0.02 to 0.55), which was not significantly different
(P = .08). TRs were documented in 16/194 (8.24%) dogs, with 1/194 (0.51%) being a
mild allergic reaction, while 15/194 (7.73%) had suspected febrile nonhemolytic TRs
(FNHTRs). FNHTR incidence was not significantly different between the LR (6/96,
6.25%, 95% CI 2.8-13.56) and N-LR (9/98, 9.18%, 95% CI 4.92-17.11) groups
(P = .81). Of the 156 dogs that survived to discharge, 80/156 received N-LR PRBC
and 76/156 received LR PRBC which was not significantly different (P = .66).
Conclusions and Clinical Importance: A clinical advantage of using LR over N-LR
PRBC in terms of TRs and increase in PCV after transfusion was not detected.

Citation

Radulescu, S. M., Skulberg, R., McDonald, C., Chan, D. L., & Humm, K. (in press). Randomized double?blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16138

Journal Article Type Article
Acceptance Date Apr 15, 2021
Online Publication Date May 7, 2021
Deposit Date Jul 15, 2021
Publicly Available Date Jul 15, 2021
Journal Journal of Veterinary Internal Medicine
Print ISSN 0891-6640
Electronic ISSN 1939-1676
Publisher Wiley Open Access
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1111/jvim.16138
Keywords General Veterinary
Public URL https://rvc-repository.worktribe.com/output/1548802
Additional Information Received: 2020-11-10; Accepted: 2021-04-15; Published: 2021-05-07

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