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Influence of endocrine disease on l-lactate concentrations in blood of ponies

Dunkel, B; Knowles, EJ; Chang, YM; Menzies-Gow, NJ


B Dunkel

EJ Knowles

YM Chang

NJ Menzies-Gow


Background Blood l-lactate concentrations are higher in people with developing or established diabetes mellitus and insulin resistance. Objectives To investigate whether blood l-lactate concentrations are positively correlated with measures of insulin dysregulation (ID) or increased autumnal ACTH concentrations in ponies. Animals Systemically healthy client-owned ponies (n = 101). Methods Prospective case-control study. Blood samples were obtained from 101 clinically healthy ponies. Breed, weight, height, and subjective and objective measures of body condition were recorded. Blood l-lactate, glucose, triglyceride, total adiponectin, and ACTH concentrations were measured and an oral sugar test (OST) was carried out. Correlations between blood l-lactate and variables of endocrine health were determined. Results Using a seasonal cutoff point of ACTH concentrations >= 47 pg/mL, 55 ponies had increased autumnal ACTH concentrations and 45 did not. Using a basal insulin concentration of >50 mu iU/mL, 42 ponies were diagnosed with ID and 58 were not. Using a 60 minutes after OST cutoff point of >45 mu iU/mL, 57 ponies had ID and 37 did not. Blood l-lactate concentrations were significantly lower in obese (average body condition score >= 7/9) compared to nonobese ponies (0.6 mmol/L; range, 0.0-1.9 mmol/L vs 0.8 mmol/L; range, 0.3-2.7 mmol/L; P = .01). No other significant correlations were detected. No differences were detected between ponies with and without increased autumnal ACTH concentrations (0.7 mmol/L; range, 0.0-2.7 mmol/L vs 0.7 mmol/L; range, 0.3-1.8 mmol/L; P = .84) and with and without ID (0.7 mmol/L; range, 0.3-2.7 mmol/L vs 0.8 mmol/L; range, 0.0-1.6 mmol/L; P = .63). Conclusions and Clinical Importance Results do not support an effect of endocrine status on l-lactate concentrations in blood of ponies.


Dunkel, B., Knowles, E., Chang, Y., & Menzies-Gow, N. (2021). Influence of endocrine disease on l-lactate concentrations in blood of ponies. Journal of Veterinary Internal Medicine, 35(3), 1582-1588.

Journal Article Type Article
Acceptance Date May 26, 2021
Publication Date 2021
Deposit Date Nov 23, 2021
Publicly Available Date Nov 23, 2021
Print ISSN 0891-6640
Publisher Wiley Open Access
Peer Reviewed Peer Reviewed
Volume 35
Issue 3
Pages 1582-1588
Keywords adiposity; equine; insulin resistance; l‐ lactate metabolism; pituitary pars intermedia dysfunction; INSULIN SENSITIVITY; ATHEROSCLEROSIS RISK; BODY CONDITION; GLUCOSE; HORSES; DEXAMETHASONE; FAT; PARTICIPANTS; ASSOCIATION
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