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Influence of endocrine disease on l-lactate concentrations in blood of ponies

Dunkel, B; Knowles, EJ; Chang, YM; Menzies-Gow, NJ

Authors

B Dunkel

EJ Knowles

YM Chang

NJ Menzies-Gow



Abstract

Background Blood l-lactate concentrations are higher in people with developing or established diabetes mellitus and insulin resistance. Objectives To investigate whether blood l-lactate concentrations are positively correlated with measures of insulin dysregulation (ID) or increased autumnal ACTH concentrations in ponies. Animals Systemically healthy client-owned ponies (n = 101). Methods Prospective case-control study. Blood samples were obtained from 101 clinically healthy ponies. Breed, weight, height, and subjective and objective measures of body condition were recorded. Blood l-lactate, glucose, triglyceride, total adiponectin, and ACTH concentrations were measured and an oral sugar test (OST) was carried out. Correlations between blood l-lactate and variables of endocrine health were determined. Results Using a seasonal cutoff point of ACTH concentrations >= 47 pg/mL, 55 ponies had increased autumnal ACTH concentrations and 45 did not. Using a basal insulin concentration of >50 mu iU/mL, 42 ponies were diagnosed with ID and 58 were not. Using a 60 minutes after OST cutoff point of >45 mu iU/mL, 57 ponies had ID and 37 did not. Blood l-lactate concentrations were significantly lower in obese (average body condition score >= 7/9) compared to nonobese ponies (0.6 mmol/L; range, 0.0-1.9 mmol/L vs 0.8 mmol/L; range, 0.3-2.7 mmol/L; P = .01). No other significant correlations were detected. No differences were detected between ponies with and without increased autumnal ACTH concentrations (0.7 mmol/L; range, 0.0-2.7 mmol/L vs 0.7 mmol/L; range, 0.3-1.8 mmol/L; P = .84) and with and without ID (0.7 mmol/L; range, 0.3-2.7 mmol/L vs 0.8 mmol/L; range, 0.0-1.6 mmol/L; P = .63). Conclusions and Clinical Importance Results do not support an effect of endocrine status on l-lactate concentrations in blood of ponies.

Citation

Dunkel, B., Knowles, E., Chang, Y., & Menzies-Gow, N. (2021). Influence of endocrine disease on l-lactate concentrations in blood of ponies. Journal of Veterinary Internal Medicine, 35(3), 1582-1588. https://doi.org/10.1111/jvim.16079

Journal Article Type Article
Acceptance Date May 26, 2021
Publication Date 2021
Deposit Date Nov 23, 2021
Publicly Available Date Nov 23, 2021
Journal Journal of Veterinary Internal Medicine
Print ISSN 0891-6640
Electronic ISSN 1939-1676
Publisher Wiley Open Access
Peer Reviewed Peer Reviewed
Volume 35
Issue 3
Pages 1582-1588
DOI https://doi.org/10.1111/jvim.16079
Keywords adiposity; equine; insulin resistance; l‐ lactate metabolism; pituitary pars intermedia dysfunction; INSULIN SENSITIVITY; ATHEROSCLEROSIS RISK; BODY CONDITION; GLUCOSE; HORSES; DEXAMETHASONE; FAT; PARTICIPANTS; ASSOCIATION
Public URL https://rvc-repository.worktribe.com/output/1552692

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