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The effect of myxomatous mitral valve disease severity on packed cell volume in dogs

Wilshaw, J; Stein, M; Lotter, N; Elliott, J; Boswood, A


J Wilshaw

M Stein

N Lotter

J Elliott

A Boswood


Objectives The aim of this study was to examine whether associations between disease severity and packed cell volume exist in dogs with myxomatous mitral valve disease. Materials and Methods Data were selected from 289 dogs that had been examined at a research clinic (2004-2017) on multiple occasions (n=1465). American College of Veterinary Internal Medicine stage and echocardiographic measurements were entered in separate multivariable linear mixed effects models with packed cell volume as the dependent variable. Age, breed, sex, weight and blood urea nitrogen concentrations were additionally tested in these analyses to control for patient characteristics. Results Packed cell volume (% whole blood) in stages B1 and B2 (B1: 42.62 +/- 0.27, P=0.001; B2: 41.77 +/- 0.42, P < 0.001) was lower than stage A (44.57 +/- 0.53). In stage C, packed cell volume was greater than both preclinical stages (C: 43.84 +/- 0.46). When the administration of loop diuretics was included in statistical models, packed cell volume was inversely related to normalised left ventricular internal diameters (beta: -2.37; 95% confidence intervals: -3.49, -1.25; P < 0.001). Clinical Significance Dogs with myxomatous mitral valve disease may develop reductions in packed cell volume as their disease progresses. Although this finding was statistically significant at a population level, it should be noted that the differences described are relatively small. This, along with other causes of variation in packed cell volume, means that changes would be challenging to appreciate within individual patients. Plasma volume depletion following diuretic administration may explain why findings differed in stage C.


Wilshaw, J., Stein, M., Lotter, N., Elliott, J., & Boswood, A. (2021). The effect of myxomatous mitral valve disease severity on packed cell volume in dogs. Journal of Small Animal Practice, 62(6), 428-436.

Journal Article Type Article
Acceptance Date Jan 9, 2021
Publication Date 2021
Deposit Date Dec 10, 2021
Publicly Available Date Dec 10, 2021
Print ISSN 0022-4510
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 62
Issue 6
Pages 428-436
Public URL


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