Determining the prevalence and risk factors for positive bacterial culture in canine discospondylitis: 120 cases

Pilkington, E; Goncalves, R; Henze, L; Grapes, N; Volk, H; De Decker, S

Abstract

BackgroundIdentification of the aetiologic agent in canine discospondylitis is infrequent; and risk factors for a positive bacterial culture have not previously been reported. MethodsMedical records at three institutions were searched to identify clinical features of dogs with discospondylitis diagnosed via radiography or cross-sectional imaging. Inclusion in this retrospective case-control study required culture of one or more samples. Multivariable binary logistic regression identified features associated with a positive culture. ResultsFifty (42%) of 120 dogs had one or more positive culture results obtained from either urine (28/115), blood (25/78), intervertebral disc aspiration (10/34) or cerebrospinal fluid (1/18). A positive culture was associated with higher bodyweight (p = 0.002, odds ratio [OR] = 1.054, 95% confidence interval [CI]: 1.019-1.089), more sample types cultured (p = 0.037, OR = 1.806, 95% CI: 1.037-3.147) and institution (p = 0.021). The presence of possibly associated preceding events (e.g., surgery), pyrexia, number of disc sites affected and serum C-reactive protein result, among other features, were not statistically significant. LimitationsAll isolates cultured were included since differentiation of true aetiologic agents from contaminants was not possible without histological confirmation and culture from surgical or postmortem biopsies. ConclusionsClinical features typically associated with infection were not identified as risk factors for positive culture in canine discospondylitis. The statistical significance of the institution suggests that standardisation of sampling protocols is necessary.

Citation

Pilkington, E., Goncalves, R., Henze, L., Grapes, N., Volk, H., & De Decker, S. (2023). Determining the prevalence and risk factors for positive bacterial culture in canine discospondylitis: 120 cases. Veterinary Record, https://doi.org/10.1002/vetr.3053

• Journal Article Type: Article
• Acceptance Date: Apr 27, 2023
• Publication Date: 2023
• Deposit Date: Feb 14, 2024
• Print ISSN: 0042-4900
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1002/vetr.3053
• Keywords: bacterial diseases; discospondylitis; dogs; neurology; MAGNETIC-RESONANCE; CLINICAL-FEATURES; VERTEBRAL OSTEOMYELITIS; BLOOD CULTURES; 10 DOGS; DISKOSPONDYLITIS; DIAGNOSIS; STAPHYLOCOCCI; GUIDELINES; DISEASES