Clinical characterisation and long‐term survival of paediatric and juvenile lymphoma in cats: 33 cases (2008‐2022)

Rogato, F; Tanis, J B; Pons Gil, B; Pittaway, C; Johnston, C A; Guillén, A

Abstract

Objectives: The aims of this study were to describe the clinical presentation, tumour characteristics, responses to chemotherapy protocols and toxicity in a cohort of cats with lymphoma up to 18 months of age. In addition, the probability of long-term (>2 years) survival was explored. Materials and MethOds: The medical records of client-owned cats aged up to 18 months diagnosed with lymphoma between 2008 and 2022 at five UK-based veterinary referral hospitals were reviewed. results: Thirty-three cats were included. The most common anatomical forms were mediastinal (42%), disseminated disease (30%) and renal (15%), with all cats having intermediate to large cell lymphoma. Three out of 29 cats tested were positive for FeLV but none for FIV. Twenty-six cats were treated with multi-agent chemotherapy protocols with complete and partial responses seen in 46% and 50% of cats, respectively. For this group, median progression-free survival was 133 days (95% confidence interval [Cl] 67 to 199) and median survival time was 268 days (95% Cl 106 to 430). Complete response to chemotherapy was associated with a longer progression-free survival. Seven cats were considered long-term survivors (>2 years). Chemotherapy was generally well tolerated with none of the long-term survivors suffering from chronic sequelae from cytotoxic treatment. clinical significance: Paediatric and juvenile cats with lymphoma showed a high response rate to multi-agent chemotherapy protocols with rare significant toxicities. The presence of long-term survivors may suggest a more favourable outcome in a subset of patients.

Citation

Rogato, F., Tanis, J. B., Pons Gil, B., Pittaway, C., Johnston, C. A., & Guillén, A. (2023). Clinical characterisation and long‐term survival of paediatric and juvenile lymphoma in cats: 33 cases (2008‐2022). Journal of Small Animal Practice, 64(12), 788-796. https://doi.org/10.1111/jsap.13667

• Journal Article Type: Article
• Acceptance Date: Jul 12, 2023
• Online Publication Date: Aug 11, 2023
• Publication Date: Aug 11, 2023
• Deposit Date: Jun 26, 2024
• Publicly Available Date: Jun 26, 2024
• Journal: Journal of Small Animal Practice
• Print ISSN: 0022-4510
• Electronic ISSN: 1748-5827
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 64
• Issue: 12
• Pages: 788-796
• DOI: https://doi.org/10.1111/jsap.13667
• Keywords: Small Animals
• Additional Information: Received: 2023-03-19; Accepted: 2023-07-12; Published: 2023-08-11