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Brain magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy reveals regional reductions in cerebral gray matter (2023)
Journal Article
Crawford, A. H., Hornby, N. L., De La Fuente, A. G., & Piercy, R. J. (2023). Brain magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy reveals regional reductions in cerebral gray matter. BMC Neuroscience, https://doi.org/10.1186/s12868-023-00788-2

Background Duchenne muscular dystrophy is a X-linked disease characterized by severe and progressive muscle weakness, alongside cognitive impairment and a range of neurobehavioral disorders secondary to brain dystrophin deficiency. Duchenne muscular... Read More about Brain magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy reveals regional reductions in cerebral gray matter.

Validation of DE50-MD dogs as a model for the cognitive and biochemical defects in the brain phenotype of Duchenne muscular dystrophy (2022)
Journal Article
Crawford, A., Hildyard, J., Rushing, S., Wells, D., Diez Leon, M., & Piercy, R. (in press). Validation of DE50-MD dogs as a model for the cognitive and biochemical defects in the brain phenotype of Duchenne muscular dystrophy. eLife, https://doi.org/10.1242/dmm.049291

Duchenne muscular dystrophy (DMD), a fatal musculoskeletal disorder, is associated with neurodevelopmental problems and cognitive impairment caused by dystrophin deficiency in the brain. Dog models of DMD represent key translational tools to study... Read More about Validation of DE50-MD dogs as a model for the cognitive and biochemical defects in the brain phenotype of Duchenne muscular dystrophy.

Imaging of focal seizures with Electrical Impedance Tomography and depth electrodes in real time (2021)
Journal Article
Witkowska-Wrobel, A., Aristovich, K., Crawford, A., Perkins, J., & Holder, D. (2021). Imaging of focal seizures with Electrical Impedance Tomography and depth electrodes in real time. NeuroImage, 234, https://doi.org/10.1016/j.neuroimage.2021.117972

A B S T R A C T Intracranial EEG is the current gold standard technique for localizing seizures for surgery, but it can be insen-sitive to tangential dipole or distant sources. Electrical Impedance Tomography (EIT) offers a novel method to improve co... Read More about Imaging of focal seizures with Electrical Impedance Tomography and depth electrodes in real time.

Human-relevant near-organ neuromodulation of the immune via the nerve (2021)
Journal Article
Donega, M., Fjordbakk, C., Kirk, J., Sokal, D., Gupta, I., Hunsberger, G., …Perkins, J. (2021). Human-relevant near-organ neuromodulation of the immune via the nerve. Proceedings of the National Academy of Sciences, 118(20), https://doi.org/10.1073/pnas.2025428118

Neuromodulation of immune function by stimulating the autonomic connections to the spleen has been demonstrated in rodent models. Consequently, neuroimmune modulation has been proposed as a new therapeutic strategy for the treatment of inflammatory c... Read More about Human-relevant near-organ neuromodulation of the immune via the nerve.

Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation (2021)
Journal Article
Aristovich, K., Donega, M., Fjordbakk, C., Tarotin, I., Chapman, C., Viscasillas, J., …Holder, D. (2021). Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation. Journal of Neuroscience Methods, 352, https://doi.org/10.1016/j.jneumeth.2021.109079

Background: Neuromodulation by electrical stimulation of the human cervical vagus nerve may be limited by adverse side effects due to stimulation of off-target organs. It may be possible to overcome this by spatially selective stimulation of peripher... Read More about Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation.

Neurological Examination In Healthy Juvenile Bearded Dragons (Pogona Vitticeps) And Adult Leopard Geckos (Eublepharis Macularius) (2021)
Journal Article
Hedley, J., MacHale, J., Rendle, M., & Crawford, A. (2021). Neurological Examination In Healthy Juvenile Bearded Dragons (Pogona Vitticeps) And Adult Leopard Geckos (Eublepharis Macularius). Journal of Herpetological Medicine and Surgery, https://doi.org/10.5818/JHMS-D-20-00006

A variety of neurological disorders have been reported in reptiles, but evaluation of a reptile patient with suspected neurological disease can be challenging. The feasibility of performing and interpreting neurological examinations may be affected b... Read More about Neurological Examination In Healthy Juvenile Bearded Dragons (Pogona Vitticeps) And Adult Leopard Geckos (Eublepharis Macularius).

Is there a link between bacteriuria and a reversible encephalopathy in dogs and cats? (2020)
Journal Article
Crawford, A. (2020). Is there a link between bacteriuria and a reversible encephalopathy in dogs and cats?. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13178

Bacteriuria has been associated with abnormal neurological status in humans, particularly the geriatric population. In this report, we review 11 cases (7 dogs and 4 cats) that support an association between bacteriuria and abnormal neurological statu... Read More about Is there a link between bacteriuria and a reversible encephalopathy in dogs and cats?.

Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo (2020)
Journal Article
Hildyard, J. C. W., Crawford, A. H., Rawson, F., Riddell, D. O., Harron, R. C. M., & Piercy, R. J. (2020). Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo. Wellcome Open Research, 5, 76. https://doi.org/10.12688/wellcomeopenres.15762.2

Background: The dystrophin gene has multiple isoforms: full-length dystrophin (dp427) is principally known for its expression in skeletal and cardiac muscle, but is also expressed in the brain, and several internal promoters give rise to shorter, N-t... Read More about Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo.

Ventral Slot Surgery to Manage Cervical Intervertebral Disc Disease in Three Cats (2018)
Journal Article
Crawford, A. H., Cappello, R., Alexander, A., & De Decker, S. (2018). Ventral Slot Surgery to Manage Cervical Intervertebral Disc Disease in Three Cats. Veterinary and Comparative Orthopaedics and Traumatology, 31(1), 71-76. https://doi.org/10.3415/vcot-17-05-0074

This is a retrospective case series evaluating client-owned cats undergoing a ventral slot surgical procedure to manage cervical intervertebral disc disease (n = 3).

Clinicopathologic Features and Magnetic Resonance Imaging Findings in 24 Cats With Histopathologically Confirmed Neurologic Feline Infectious Peritonitis (2017)
Journal Article
Crawford, A. H., Stoll, A. L., Sanchez-Masian, D., Shea, A., Michaels, J., Fraser, A. R., & Beltran, E. (2017). Clinicopathologic Features and Magnetic Resonance Imaging Findings in 24 Cats With Histopathologically Confirmed Neurologic Feline Infectious Peritonitis. Journal of Veterinary Internal Medicine, 31(5), 1477-1486. https://doi.org/10.1111/jvim.14791

Background: Feline infectious peritonitis (FIP) is the most common infectious central nervous system (CNS) disease in the cat and is invariably fatal. Improved means of antemortem diagnosis is required to facilitate clinical decision making. Informat... Read More about Clinicopathologic Features and Magnetic Resonance Imaging Findings in 24 Cats With Histopathologically Confirmed Neurologic Feline Infectious Peritonitis.

MRI and clinical resolution of a suspected intracranial toxoplasma granuloma with medical treatment in a domestic short hair cat (2017)
Journal Article
Crawford, A. H., Drees, R., & Beltran, E. (2017). MRI and clinical resolution of a suspected intracranial toxoplasma granuloma with medical treatment in a domestic short hair cat. https://doi.org/10.1136/vetreccr-2017-000480

A two-year-old cat was presented with a left paradoxical vestibular syndrome. MRI of the brain revealed an extra-axial homogenously contrast enhancing mass in the region of the left caudal cerebellar peduncle. Toxoplasma serology was consistent with... Read More about MRI and clinical resolution of a suspected intracranial toxoplasma granuloma with medical treatment in a domestic short hair cat.

Clinical presentation and outcome of dogs treated medically or surgically for thoracolumbar intervertebral disc protrusion (2017)
Journal Article
Crawford, A. H., & De Decker, S. (2017). Clinical presentation and outcome of dogs treated medically or surgically for thoracolumbar intervertebral disc protrusion. Veterinary Record, 180(23), https://doi.org/10.1136/vr.103871

To date, few studies have investigated the clinical characteristics of thoracolumbar intervertebral disc protrusion (IVDP). The aim of this retrospective study was to evaluate the presentation and outcome of dogs receiving medical or surgical treatme... Read More about Clinical presentation and outcome of dogs treated medically or surgically for thoracolumbar intervertebral disc protrusion.

Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination (2017)
Journal Article
Crawford, A. H., Tripathi, R. B., Foerster, S., McKenzie, I., Kougioumtzidou, E., Grist, M., …Franklin, R. J. (2017). Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination. American Journal of Pathology, 186(3), 511-6. https://doi.org/10.1016/j.ajpath.2015.11.005

Remyelination is the regenerative response to demyelination. Although the oligodendrocyte progenitor is established as the major source of remyelinating cells, there is no conclusive evidence on whether mature, differentiated oligodendrocytes can als... Read More about Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination.

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline (2016)
Journal Article
Crawford, A. H., Tripathi, R. B., Richardson, W. D., & Franklin, R. J. M. (2016). Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline. Cell Reports, 15(4), 761-773. https://doi.org/10.1016/j.celrep.2016.03.069

Oligodendrocyte progenitors (OPs) arise from distinct ventral and dorsal domains within the ventricular germinal zones of the embryonic CNS. The functional significance, if any, of these different populations is not known. Using dual-color reporter m... Read More about Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline.

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination (2015)
Journal Article
Natrajan, M. S., De La Fuente, A. G., Crawford, A. H., Lineham, E., Nuñez, V., Johnson, K. R., …Franklin, R. J. (2015). Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. Brain, 138(Pt12), 3581-97. https://doi.org/10.1093/brain/awv289

The efficiency of central nervous system remyelination declines with age. This is in part due to an age-associated decline in the phagocytic removal of myelin debris, which contains inhibitors of oligodendrocyte progenitor cell differentiation. In th... Read More about Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.

Oligodendrocyte progenitors: adult stem cells of the central nervous system (2014)
Journal Article
Crawford, A. H., Stockley, J. H., Tripathi, R. B., Richardson, W. D., & Franklin, R. J. (2014). Oligodendrocyte progenitors: adult stem cells of the central nervous system. Experimental Neurology, 260, 50-5. https://doi.org/10.1016/j.expneurol.2014.04.027

Oligodendrocyte progenitors (OPs) are a major proliferating cell population within the adult CNS. In response to myelin loss or increasing demand, OPs have the capacity to differentiate into mature, myelinating oligodendrocytes. The name ‘oligodendro... Read More about Oligodendrocyte progenitors: adult stem cells of the central nervous system.