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All Outputs (33)

Ventral Slot Surgery to Manage Cervical Intervertebral Disc Disease in Three Cats (2018)
Journal Article
Crawford, A. H., Cappello, R., Alexander, A., & De Decker, S. (2018). Ventral Slot Surgery to Manage Cervical Intervertebral Disc Disease in Three Cats. Veterinary and Comparative Orthopaedics and Traumatology, 31(1), 71-76. https://doi.org/10.3415/vcot-17-05-0074

This is a retrospective case series evaluating client-owned cats undergoing a ventral slot surgical procedure to manage cervical intervertebral disc disease (n = 3).

Clinicopathologic Features and Magnetic Resonance Imaging Findings in 24 Cats With Histopathologically Confirmed Neurologic Feline Infectious Peritonitis (2017)
Journal Article
Crawford, A. H., Stoll, A. L., Sanchez-Masian, D., Shea, A., Michaels, J., Fraser, A. R., & Beltran, E. (2017). Clinicopathologic Features and Magnetic Resonance Imaging Findings in 24 Cats With Histopathologically Confirmed Neurologic Feline Infectious Peritonitis. Journal of Veterinary Internal Medicine, 31(5), 1477-1486. https://doi.org/10.1111/jvim.14791

Background: Feline infectious peritonitis (FIP) is the most common infectious central nervous system (CNS) disease in the cat and is invariably fatal. Improved means of antemortem diagnosis is required to facilitate clinical decision making. Informat... Read More about Clinicopathologic Features and Magnetic Resonance Imaging Findings in 24 Cats With Histopathologically Confirmed Neurologic Feline Infectious Peritonitis.

MRI and clinical resolution of a suspected intracranial toxoplasma granuloma with medical treatment in a domestic short hair cat (2017)
Journal Article
Crawford, A. H., Drees, R., & Beltran, E. (2017). MRI and clinical resolution of a suspected intracranial toxoplasma granuloma with medical treatment in a domestic short hair cat. https://doi.org/10.1136/vetreccr-2017-000480

A two-year-old cat was presented with a left paradoxical vestibular syndrome. MRI of the brain revealed an extra-axial homogenously contrast enhancing mass in the region of the left caudal cerebellar peduncle. Toxoplasma serology was consistent with... Read More about MRI and clinical resolution of a suspected intracranial toxoplasma granuloma with medical treatment in a domestic short hair cat.

Clinical presentation and outcome of dogs treated medically or surgically for thoracolumbar intervertebral disc protrusion (2017)
Journal Article
Crawford, A. H., & De Decker, S. (2017). Clinical presentation and outcome of dogs treated medically or surgically for thoracolumbar intervertebral disc protrusion. Veterinary Record, 180(23), https://doi.org/10.1136/vr.103871

To date, few studies have investigated the clinical characteristics of thoracolumbar intervertebral disc protrusion (IVDP). The aim of this retrospective study was to evaluate the presentation and outcome of dogs receiving medical or surgical treatme... Read More about Clinical presentation and outcome of dogs treated medically or surgically for thoracolumbar intervertebral disc protrusion.

Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination (2017)
Journal Article
Crawford, A. H., Tripathi, R. B., Foerster, S., McKenzie, I., Kougioumtzidou, E., Grist, M., Richardson, W. D., & Franklin, R. J. (2017). Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination. American Journal of Pathology, 186(3), 511-6. https://doi.org/10.1016/j.ajpath.2015.11.005

Remyelination is the regenerative response to demyelination. Although the oligodendrocyte progenitor is established as the major source of remyelinating cells, there is no conclusive evidence on whether mature, differentiated oligodendrocytes can als... Read More about Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination.

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline (2016)
Journal Article
Crawford, A. H., Tripathi, R. B., Richardson, W. D., & Franklin, R. J. M. (2016). Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline. Cell Reports, 15(4), 761-773. https://doi.org/10.1016/j.celrep.2016.03.069

Oligodendrocyte progenitors (OPs) arise from distinct ventral and dorsal domains within the ventricular germinal zones of the embryonic CNS. The functional significance, if any, of these different populations is not known. Using dual-color reporter m... Read More about Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline.

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination (2015)
Journal Article
Natrajan, M. S., De La Fuente, A. G., Crawford, A. H., Lineham, E., Nuñez, V., Johnson, K. R., Wu, T., Fitzgerald, D. C., Ricote, M., Bielekova, B., & Franklin, R. J. (2015). Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. Brain, 138(Pt12), 3581-97. https://doi.org/10.1093/brain/awv289

The efficiency of central nervous system remyelination declines with age. This is in part due to an age-associated decline in the phagocytic removal of myelin debris, which contains inhibitors of oligodendrocyte progenitor cell differentiation. In th... Read More about Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.

Oligodendrocyte progenitors: adult stem cells of the central nervous system (2014)
Journal Article
Crawford, A. H., Stockley, J. H., Tripathi, R. B., Richardson, W. D., & Franklin, R. J. (2014). Oligodendrocyte progenitors: adult stem cells of the central nervous system. Experimental Neurology, 260, 50-5. https://doi.org/10.1016/j.expneurol.2014.04.027

Oligodendrocyte progenitors (OPs) are a major proliferating cell population within the adult CNS. In response to myelin loss or increasing demand, OPs have the capacity to differentiate into mature, myelinating oligodendrocytes. The name ‘oligodendro... Read More about Oligodendrocyte progenitors: adult stem cells of the central nervous system.