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A conserved role of the Hippo signalling pathway in initiation of the first lineage specification event across mammals (2023)
Journal Article
Gerri, C., McCarthy, A., Scott, G., Regin, M., Stamatiadis, P., Brumm, S., …Niakan, K. (2023). A conserved role of the Hippo signalling pathway in initiation of the first lineage specification event across mammals. Development, 150(8), https://doi.org/10.1242/dev.201112

Our understanding of the molecular events driving cell specification in early mammalian development relies mainly on mouse studies, and it remains unclear whether these mechanisms are conserved across mammals, including humans. We have shown that the... Read More about A conserved role of the Hippo signalling pathway in initiation of the first lineage specification event across mammals.

Combined effect of probiotics and specific immunoglobulin Y directed against Escherichia coli on growth performance, diarrhea incidence, and immune system in calves (2021)
Journal Article
Karamzadeh-Dehaghani, A., Towhidi, A., Zhandi, M., Mojgani, N., & Fouladi-Nashta, A. (2021). Combined effect of probiotics and specific immunoglobulin Y directed against Escherichia coli on growth performance, diarrhea incidence, and immune system in calves. animal, 15(2), https://doi.org/10.1016/j.animal.2020.100124

Enterotoxigenic Escherichia coli (ETEC) K99 is one of the major pathogens associated with calf diarrhea. The induction of passive immunity in animals by immunoglobulin Y and using probiotics are inexpensive alternatives to antibiotics for the prevent... Read More about Combined effect of probiotics and specific immunoglobulin Y directed against Escherichia coli on growth performance, diarrhea incidence, and immune system in calves.

Initiation of a conserved trophectoderm program in human, cow and mouse embryos (2020)
Journal Article
Gerri, C., McCarthy, A., Alanis-Lobato, G., Demtschenko, A., Bruneau, A., Loubersac, S., Fogarty, N. M. E., Hampshire, D., Elder, K., Snell, P., Christie, L., David, L., Van de Velde, H., Fouladi-Nashta, A. A., & Niakan, K. K. (2020). Initiation of a conserved trophectoderm program in human, cow and mouse embryos. Nature, https://doi.org/10.1038/s41586-020-2759-x

Current understandings of cell specification in early mammalian pre-implantation development are based mainly on mouse studies. The first lineage differentiation event occurs at the morula stage, with outer cells initiating a trophectoderm (TE) place... Read More about Initiation of a conserved trophectoderm program in human, cow and mouse embryos.

Polyunsaturated fatty acids influence offspring sex ratio in cows (2019)
Journal Article
Marei, W. F. A., Khalil, W. A., Pushpakumara, P. G. A., El-Harairy, M. A., Abo El-Atta, A. M. A., Wathes, D. C., & Fouladi-Nashta, A. A. (2019). Polyunsaturated fatty acids influence offspring sex ratio in cows. https://doi.org/10.1016/j.ijvsm.2018.01.006

Dietary polyunsaturated fatty acids (PUFAs) can influence fertility in farm animals. Some evidence in mice and sheep have suggested that PUFAs may influence offspring sex ratio, which may have significant value for cattle production. To test this hyp... Read More about Polyunsaturated fatty acids influence offspring sex ratio in cows.

Effect of oral administration of pioglitazone on follicular dynamics in Holstein dairy cows (2019)
Journal Article
Yousefi, A. R., Kohram, H., Zare Shahneh, A., Zamiri, M. J., Dirandeh, E., Kazemi Khoozani, M., …Fouladi-Nashta, A. A. (2019). Effect of oral administration of pioglitazone on follicular dynamics in Holstein dairy cows. Livestock Science, 224, 50-56. https://doi.org/10.1016/j.livsci.2019.04.001

This study investigated the effects of oral administration of pioglitazone (PGT), a specific and synthetic ligand of peroxisome proliferator-activated receptors gamma (PPARγ), on follicular dynamics and corpus luteum (CL) functionality in dairy cows.... Read More about Effect of oral administration of pioglitazone on follicular dynamics in Holstein dairy cows.

Potential of milk mid-IR spectra to predict metabolic status of cows through blood components and an innovative clustering approach (2019)
Journal Article
Grelet, C., Vanlierde, A., Hostens, M., Foldager, L., Salavati, M., Ingvartsen, K. L., …GplusE Consortium, . (2019). Potential of milk mid-IR spectra to predict metabolic status of cows through blood components and an innovative clustering approach. animal, 13(3), 649-658. https://doi.org/10.1017/S1751731118001751

Unbalanced metabolic status in the weeks after calving predisposes dairy cows to metabolic and infectious diseases. Blood glucose, IGF-I, non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHB) are used as indicators of the metabolic status of... Read More about Potential of milk mid-IR spectra to predict metabolic status of cows through blood components and an innovative clustering approach.

Sperm preparation through Sephadex™ filtration improves in vitro fertilization rate of buffalo oocytes (2018)
Journal Article
Husna, A. U., Azam, A., Qadeer, S., Awan, M. A., Nasreen, S., Shahzad, Q., …Akhter, S. (2018). Sperm preparation through Sephadex™ filtration improves in vitro fertilization rate of buffalo oocytes. Reproduction in Domestic Animals, 53(2), 377-384. https://doi.org/10.1111/rda.13117

Routinely, swim-up method is used to separate high-quality sperm; however, long processing time and close cell-to-cell contact during the centrifugation step are inevitable elements of oxidative stress to sperm. The objective was to evaluate Sephadex... Read More about Sperm preparation through Sephadex™ filtration improves in vitro fertilization rate of buffalo oocytes.

Immunolocalization of angiogenic growth factors in the ovine uterus during the oestrus cycle and in response to Steroids (2018)
Journal Article
Tremaine, T. D., & Fouladi-Nashta, A. A. (2018). Immunolocalization of angiogenic growth factors in the ovine uterus during the oestrus cycle and in response to Steroids. Reproduction in Domestic Animals, 53(3), 667-679. https://doi.org/10.1111/rda.13156

The vascular changes associated with endometrial maturation in preparation for embryo implantation depend on numerous growth factors, known to regulate key angiogenic events. Primarily, the vascular endothelial growth factor (VEGF) family promotes va... Read More about Immunolocalization of angiogenic growth factors in the ovine uterus during the oestrus cycle and in response to Steroids.

Effect of melatonin supplementation in the long-term preservation of the sheep ovaries at different temperatures and subsequent in vitro embryo production (2018)
Journal Article
Goodarzi, A., Zare Shahneh, A., Kohram, H., Sadeghi, M., Moazenizadeh, M. H., Fouladi-Nashta, A. A., & Dadashpour Davachi, N. (2018). Effect of melatonin supplementation in the long-term preservation of the sheep ovaries at different temperatures and subsequent in vitro embryo production. Theriogenology, 106, 265-270. https://doi.org/10.1016/j.theriogenology.2017.10.009

Investigations in the past decades have shown that oocytes developmental competence following in vitro fertilization is greatly influenced by an interval between isolation of the ovaries immediately after death/slaughter and oocytes recovery from the... Read More about Effect of melatonin supplementation in the long-term preservation of the sheep ovaries at different temperatures and subsequent in vitro embryo production.

Supplementing a-Linolenic acid in the in vitro maturation media improves nuclear maturation rate of oocytes and early embryonic development in the Nili Ravi buffalo (2017)
Journal Article
Azam, A., Shahzad, Q., Ul-Husna, A., Qadee, S., Ejaz, R., Fouladi-Nashta, A. A., …Akhter, S. (2017). Supplementing a-Linolenic acid in the in vitro maturation media improves nuclear maturation rate of oocytes and early embryonic development in the Nili Ravi buffalo. Animal Reproduction Science, 14(4), 1161-119. https://doi.org/10.21451/1984-3143-AR859

The present study was conducted to investigate the effect of omega-3 poly unsaturated fatty acid (PUFA), α-linolenic acid (ALA; 18:3 n-3) on the in vitro maturation (IVM) of buffalo oocytes and subsequent embryonic development. Buffalo cumulusoocyte... Read More about Supplementing a-Linolenic acid in the in vitro maturation media improves nuclear maturation rate of oocytes and early embryonic development in the Nili Ravi buffalo.

Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep (2017)
Journal Article
Marei, W. F. A., Wathes, D. C., Raheem, K. A., Mohey-Elsaeed, O., Ghafari, F., & Fouladi-Nashta, A. A. (2017). Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep. https://doi.org/10.1071/RD16232

An increasing number of reports suggests a role of hyaluronan (HA) in female reproduction and interest in its application in assisted reproduction is rising. However, there are contrasting data about the effectiveness of adding HA to the embryo-trans... Read More about Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep.

Bovine Endometrial Cells Mount Innate Immune Response to the Intracellular Ligands CL097 and Poly(dA:dT) Indicating Roles against Uterine Viruses (2017)
Journal Article
Oguejiofor, C. F., Cheng, Z. R., Fouladi-Nashta, A. A., & Wathes, D. C. (2017). Bovine Endometrial Cells Mount Innate Immune Response to the Intracellular Ligands CL097 and Poly(dA:dT) Indicating Roles against Uterine Viruses. Open Journal of Animal Sciences, 7(2), https://doi.org/10.4236/ojas.2017.72010

Uterine infection and endometritis cause infertility and economic losses in the cattle industry. The innate immune response of the endometrium is critical in the elimination of pathogenic organisms that invade the uterus in postpartum cows. This stud... Read More about Bovine Endometrial Cells Mount Innate Immune Response to the Intracellular Ligands CL097 and Poly(dA:dT) Indicating Roles against Uterine Viruses.

Hyaluronan and Hyaluronidase, which is better for embryo development? (2016)
Journal Article
Marei, W. F. A., Raheem, K. A., Salavati, M., Tremaine, T., Khalid, M., & Fouladi-Nashta, A. A. (2016). Hyaluronan and Hyaluronidase, which is better for embryo development?. Theriogenology, 86(4), 940-948. https://doi.org/10.1016/j.theriogenology.2016.03.017

Our aim was to examine size-specific effects of Hyaluronan (HA) on preimplantation embryo development. We investigated the effects of Hyalovet (HA, 500–750 kDa; the size produced by HA synthase-3, which is abundant in the oviduct), or HA treated with... Read More about Hyaluronan and Hyaluronidase, which is better for embryo development?.

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide (2015)
Journal Article
Oguejiofor, C. F., Cheng, Z. R., Abudureyimu, A., Anstaett, O. L., Brownlie, J., Fouladi-Nashta, A. A., & Wathes, D. C. (2015). Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide. Biology of Reproduction, 93(4), https://doi.org/10.1095/biolreprod.115.128876

Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial... Read More about Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide.

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. I. Effect of Lipopolysaccharide on Innate Immunity (2015)
Journal Article
Oguejiofor, C. F., Cheng, Z. R., Abudureyimu, A., Fouladi-Nashta, A. A., & Wathes, D. C. (2015). Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. I. Effect of Lipopolysaccharide on Innate Immunity. Biology of Reproduction, 93(4), https://doi.org/10.1095/biolreprod.115.128868

The dysregulation of endometrial immune response to bacterial lipopolysaccharide (LPS) has been implicated in uterine disease and infertility in the postpartum dairy cow, although the mechanisms are not clear. Here, we investigated whole-transcriptom... Read More about Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. I. Effect of Lipopolysaccharide on Innate Immunity.