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All Outputs (11)

Hollow-fibre infection model: adaptations for the culture and assessment of fastidious organisms (2024)
Journal Article
Mead, A., Azzariti, S., & Pelligand, L. (2024). Hollow-fibre infection model: adaptations for the culture and assessment of fastidious organisms. Access Microbiology, 6(6), https://doi.org/10.1099/acmi.0.000744.v3

The Hollow-fibre Infection Model (HFIM) is a valuable in vitro platform for emulating antimicrobial drug (AMD) pharmacokinetic (PK) profiles. Despite its potential, standardized protocols for HFIM operation, especially concerning fastidious organisms... Read More about Hollow-fibre infection model: adaptations for the culture and assessment of fastidious organisms.

Microplastics in human urine: Characterisation using μFTIR and sampling challenges using healthy donors and endometriosis participants (2024)
Journal Article
Rotchell, J. M., Austin, C., Chapman, E., Atherall, C. A., Liddle, C. R., Dunstan, T. S., Blackburn, B., Mead, A., Filart, K., Beeby, E., Cunningham, K., Allen, J., Draper, H., & Guinn, B.-A. (2024). Microplastics in human urine: Characterisation using μFTIR and sampling challenges using healthy donors and endometriosis participants. Ecotoxicology and Environmental Safety, 274, 116208. https://doi.org/10.1016/j.ecoenv.2024.116208

Microplastics (MPs) are found in all environments, within the human food chain, and have been recently detected in several human tissues. The objective herein was to undertake an analysis of MP contamination in human urine samples, from healthy indiv... Read More about Microplastics in human urine: Characterisation using μFTIR and sampling challenges using healthy donors and endometriosis participants.

CellShip: An Ambient Temperature Transport and Short-Term Storage Medium for Mammalian Cell Cultures (2023)
Journal Article
Buick, E., Mead, A., Alhubaysh, A., Bou Assi, P., Das, P., Dayus, J., Turner, M., Kowalski, L., Murray, J., Renshaw, D., & Farnaud, S. (in press). CellShip: An Ambient Temperature Transport and Short-Term Storage Medium for Mammalian Cell Cultures. Biopreservation and Biobanking, https://doi.org/10.1089/bio.2023.0100

Cell culture is a critical platform for numerous research and industrial processes. However, methods for transporting cells are largely limited to cryopreservation, which is logistically challenging, requires the use of potentially cytotoxic cryopres... Read More about CellShip: An Ambient Temperature Transport and Short-Term Storage Medium for Mammalian Cell Cultures.

Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens (2023)
Journal Article
Mead, A., Toutain, P.-L., Richez, P., & Pelligand, L. (2023). Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens. Scientific Reports, 13, Article 12822. https://doi.org/10.1038/s41598-023-39727-w

The dosage of colistin for the treatment of enteric E. coli in animals necessitates considering the heteroresistant (HR) nature of the targeted inoculum, described by the presence of a major susceptible population (S1, representing 99.95% of total po... Read More about Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens.

Quantitative pharmacodynamic characterization of resistance vs. heteroresistance of colistin in E. coli using a semi-mechanistic modelling of killing curves (2022)
Journal Article
Mead, A., Toutain, P.-L., Richez, P., & Pelligand, L. (2022). Quantitative pharmacodynamic characterization of resistance vs. heteroresistance of colistin in E. coli using a semi-mechanistic modelling of killing curves. Antimicrobial Agents and Chemotherapy, https://doi.org/10.1128/aac.00793-22

Heteroresistance correspond to the presence in a bacterial isolate of an initial small subpopulation of bacteria characterized by a significant reduction in their sensitivity to a given antibiotic. Mechanisms of heteroresistance vs. resistance are po... Read More about Quantitative pharmacodynamic characterization of resistance vs. heteroresistance of colistin in E. coli using a semi-mechanistic modelling of killing curves.

Supplementary Data: Quantitative pharmacodynamic characterization of resistance vs. heteroresistance of colistin in E. coli using a semi-mechanistic modelling of killing curves (2022)
Data
Mead, A., Toutain, P.-L., Richez, P., & Pelligand, L. Supplementary Data: Quantitative pharmacodynamic characterization of resistance vs. heteroresistance of colistin in E. coli using a semi-mechanistic modelling of killing curves. [Data]

Data for:
Quantitative pharmacodynamic characterization of resistance vs. heteroresistance of colistin in E. coli using a semi-mechanistic modelling of killing curves

Epidemiological prevalence of phenotypical resistances and mobilised colistin resistance in avian commensal and pathogenic E. coli from Denmark, France, Netherlands and UK (2022)
Journal Article
Mead, A., Billon-Lotz, C., Olsen, R., Swift, B., Richez, P., Stabler, R., & Pelligand, L. (2022). Epidemiological prevalence of phenotypical resistances and mobilised colistin resistance in avian commensal and pathogenic E. coli from Denmark, France, Netherlands and UK. Antibiotics, https://doi.org/10.3390/antibiotics11050631

Colistin has been used for treatment of non-invasive gastrointestinal infections caused by avian pathogenic E. coli (APEC). The discovery of mobilised colistin resistance (mcr) in E. coli [1] has instigated a One Health approach to minimise colistin... Read More about Epidemiological prevalence of phenotypical resistances and mobilised colistin resistance in avian commensal and pathogenic E. coli from Denmark, France, Netherlands and UK.

Pharmacokinetics of Colistin in the Gastrointestinal Tract of Poultry Following Dosing via Drinking Water and Its Bactericidal Impact on Enteric Escherichia coli (2021)
Journal Article
Mead, A., Richez, P., Azzariti, S., & Pelligand, L. (2021). Pharmacokinetics of Colistin in the Gastrointestinal Tract of Poultry Following Dosing via Drinking Water and Its Bactericidal Impact on Enteric Escherichia coli. Frontiers in Veterinary Science, 8, https://doi.org/10.3389/fvets.2021.698135

Colistin, a last-line antibiotic of major importance in veterinary medicine and of critical importance in human medicine, is authorized to treat gastrointestinal (enteric) infections caused by non-invasive Escherichia coli in multiple veterinary spec... Read More about Pharmacokinetics of Colistin in the Gastrointestinal Tract of Poultry Following Dosing via Drinking Water and Its Bactericidal Impact on Enteric Escherichia coli.

Determination of colistin in luminal and parietal intestinal matrices of chicken by ultra-high performance liquid chromatography-tandem mass spectrometry (2021)
Journal Article
Mead, A., Gillard, N., Robert, C., Richez, P., Pierret, G., Henrottin, J., & Pelligand, L. (2021). Determination of colistin in luminal and parietal intestinal matrices of chicken by ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13022

Justification for continued use of colistin in veterinary medicine, e.g. medicated water, relies on pharmacokinetic/pharmacodynamic (PK/PD) studies that require accurate measurement of colistin content in the digestive tract. A method for the detect... Read More about Determination of colistin in luminal and parietal intestinal matrices of chicken by ultra-high performance liquid chromatography-tandem mass spectrometry.

Pharmacokinetics of colistin in the gastrointestinal tract of poultry following dosing via drinking water, and the bactericidal impact on enteric E. coli. (2021)
Journal Article
Mead, A., Richez, P., Azzariti, S., & Pelligand, L. (2021). Pharmacokinetics of colistin in the gastrointestinal tract of poultry following dosing via drinking water, and the bactericidal impact on enteric E. coli. Frontiers in Veterinary Science,

Colistin, a last line antibiotic of major importance in veterinary medicine and critical importance in human medicine, is authorised to treat gastrointestinal (enteric) infections caused by non-invasive E. coli in multiple veterinary species includin... Read More about Pharmacokinetics of colistin in the gastrointestinal tract of poultry following dosing via drinking water, and the bactericidal impact on enteric E. coli..