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All Outputs (9)

Regional variations in discrete collagen fibre mechanics within intact intervertebral disc resolved using synchrotron computed tomography and digital volume correlation (2022)
Journal Article
Disney, C., Mo, J., Eckersley, A., Bodey, A., Hoyland, J., Sherratt, M., Pitsillides, A., Lee, P., & Bay, B. (2022). Regional variations in discrete collagen fibre mechanics within intact intervertebral disc resolved using synchrotron computed tomography and digital volume correlation. Acta Biomaterialia, 138, 361-374. https://doi.org/10.1016/j.actbio.2021.10.012

Many soft tissues, such as the intervertebral disc (IVD), have a hierarchical fibrous composite structure which suffers from regional damage. We hypothesise that these tissue regions have distinct, inherent fibre structure and structural response upo... Read More about Regional variations in discrete collagen fibre mechanics within intact intervertebral disc resolved using synchrotron computed tomography and digital volume correlation.

A new method for segmentation and analysis of bone callus in rodent fracture models using micro-CT (2022)
Journal Article
Hopkinson, M., Jones, G., Evans, L., Gohin, S., Magnusdottir, R., Salmon, P., Chenu, C., Meeson, R., Javaheri, B., & Pitsillides, A. (2022). A new method for segmentation and analysis of bone callus in rodent fracture models using micro-CT. Journal of Orthopaedic Research, https://doi.org/10.1002/jor.25507

Fracture burden has created a need to better understand bone repair processes under different pathophysiological states. Evaluation of structural and material properties of the mineralized callus, which is integral to restoring biomechanical stabilit... Read More about A new method for segmentation and analysis of bone callus in rodent fracture models using micro-CT.

Biofabrication of the osteochondral unit and its applications: Current and future directions for 3D bioprinting (2022)
Journal Article
Santos-Beato, P., Midha, S., Pitsillides, A., Miller, A., Torii, R., & Kalaskar, D. (2022). Biofabrication of the osteochondral unit and its applications: Current and future directions for 3D bioprinting. Journal of Tissue Engineering, 13, https://doi.org/10.1177/20417314221133480

Multiple prevalent diseases, such as osteoarthritis (OA), for which there is no cure or full understanding, affect the osteochondral unit; a complex interface tissue whose architecture, mechanical nature and physiological characteristics are still ye... Read More about Biofabrication of the osteochondral unit and its applications: Current and future directions for 3D bioprinting.

Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy (2022)
Journal Article
Hsu, S., Stephen, L., Dillon, S., Milne, E., Javaheri, B., Pitsillides, A., Novak, A., Millan, J., MacRae, V., Staines, K., & Farquharson, C. (2022). Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy. Journal of Endocrinology, 254(3), 167-181. https://doi.org/10.1530/JOE-22-0097

Patients with advanced chronic kidney disease (CKD) often present with skeletal abnormalities, a condition known as renal osteodystrophy (ROD). While tissue non-specific alkaline phosphatase (TNAP) and PHOSPHO1 are critical for bone mineralization, t... Read More about Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy.

MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis (2022)
Journal Article
Pistorius, K., Ly, L., Souza, P., Gomez, E., Koenis, D., Rodriguez, A., Foster, J., Sosabowski, J., Hopkinson, M., Rajeeve, V., Spur, B., Pitsillides, A., Pitzalis, C., & Dalli, J. (2022). MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis. EBioMedicine, 79, https://doi.org/10.1016/j.ebiom.2022.103974

Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints (2022)
Journal Article
Ajami, S., Javaheri, B., Chang, Y., Maruthainar, N., Khan, T., Donaldson, J., Pitsillides, A., & Liu, C. (2022). Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints. Scientific Reports, 12(1), https://doi.org/10.1038/s41598-022-10600-6

Early diagnosis of osteoarthritis (OA), before the onset of irreversible changes is crucial for understanding the disease process and identifying potential disease-modifying treatments from the earliest stage. OA is a whole joint disease and affects... Read More about Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints.

Moving beyond the limits of detection: the past, the present, and the future of diagnostic imaging in canine osteoarthritis (2022)
Journal Article
Jones, G., Pitsillidies, A., & Meeson, R. (2022). Moving beyond the limits of detection: the past, the present, and the future of diagnostic imaging in canine osteoarthritis. Frontiers in Veterinary Science, https://doi.org/10.3389/fvets.2022.789898

Osteoarthritis (OA) is the most common orthopaedic condition in dogs, characterised as chronic, painful end-point of a synovial joint with limited therapeutic options other than palliative pain control or surgical salvage. Since the 1970s, radiograph... Read More about Moving beyond the limits of detection: the past, the present, and the future of diagnostic imaging in canine osteoarthritis.