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Interleukin-2 and interferon-gamma mRNA expression in canine anal furunculosis lesions and the effect of ciclosporin therapy
Journal Article
Tivers, M. S., Catchpole, B., Gregory, S. P., & House, A. K. Interleukin-2 and interferon-gamma mRNA expression in canine anal furunculosis lesions and the effect of ciclosporin therapy. Veterinary Immunology and Immunopathology, 125(1/2), 31-36. https://doi.org/10.1016/j.vetimm.2008.04.018

German Shepherd Dogs have an increased incidence of anal furunculosis (AF), which is a disease characterized by inflammation and ulceration of the perianal tissues. Ciclosporin, an immunosuppressive drug, has been successfully used to treat AF, sugge... Read More about Interleukin-2 and interferon-gamma mRNA expression in canine anal furunculosis lesions and the effect of ciclosporin therapy.

Canine diabetes mellitus: from phenotype to genotype
Journal Article
Catchpole, B., Kennedy, L. J., Davison, L. J., & Ollier, W. E. R. Canine diabetes mellitus: from phenotype to genotype. Journal of Small Animal Practice, 49(1), 4-10. https://doi.org/10.1111/j.1748-5827.2007.00398.x

Breed differences in susceptibility to diabetes mellitus in dogs suggest an underlying genetic component to the pathogenesis of the disease. There is little evidence for an equivalent of human type 2 diabetes in dogs, and it has been proposed that ca... Read More about Canine diabetes mellitus: from phenotype to genotype.

Evaluation of a disposable device for the measurement of haemoglobin A1c in dogs
Journal Article
Catchpole, B., Mountford, S., Barabas, S., & Scaramuzzi, R. J. Evaluation of a disposable device for the measurement of haemoglobin A1c in dogs. Veterinary Record, 162(2), 47-49

A disposable device designed for measuring glycated haemoglobin (HbA1c) in human blood was evaluated for use in dogs. EDTA blood samples were collected from 50 normoglycaemic dogs, 10 dogs suffering from anaemia and 112 diabetic dogs. HbA1c was measu... Read More about Evaluation of a disposable device for the measurement of haemoglobin A1c in dogs.

Anti-Insulin Antibodies in Diabetic Dogs Before and After Treatment with Different Insulin Preparations
Journal Article
Davison, L. J., Walding, B. R., Herrtage, M. E., & Catchpole, B. Anti-Insulin Antibodies in Diabetic Dogs Before and After Treatment with Different Insulin Preparations. Journal of Veterinary Internal Medicine, 22(6), 1317-1325. https://doi.org/10.1111/j.1939-1676.2008.0194.x

Background: Anti-insulin antibodies (AIA) occur in diabetic dogs after insulin therapy, although their clinical significance is unclear. Hypothesis: Treatment of diabetic dogs with heterologous insulin is more likely to stimulate production of AIA th... Read More about Anti-Insulin Antibodies in Diabetic Dogs Before and After Treatment with Different Insulin Preparations.

Autoantibodies to GAD65 and IA-2 in canine diabetes mellitus
Journal Article
Davison, L. J., Weenink, S. M., Christie, M. R., Herrtage, M. E., & Catchpole, B. Autoantibodies to GAD65 and IA-2 in canine diabetes mellitus. Veterinary Immunology and Immunopathology, 126(1-2), 83-90. https://doi.org/10.1016/j.vetimm.2008.06.016

Diabetes mellitus in dogs shares many characteristics with the human type 1 disease and virtually all diabetic dogs require insulin therapy to control hyperglycaemia. Insulin deficiency is suspected to result from immune-mediated destruction of pancr... Read More about Autoantibodies to GAD65 and IA-2 in canine diabetes mellitus.

Pattern-recognition receptor mRNA expression and function in canine monocyte/macrophages and relevance to canine anal furunuclosis
Journal Article
House, A. K., Gregory, S. P., & Catchpole, B. Pattern-recognition receptor mRNA expression and function in canine monocyte/macrophages and relevance to canine anal furunuclosis. Veterinary Immunology and Immunopathology, 124(3-4), 230-240. https://doi.org/10.1016/j.vetimm.2008.03.012

Pattern-recognition receptors (PRRs) are important components of the innate immune system, enabling early detection of infection. Defective PRR function has been implicated in several infectious and immune-mediated diseases of human beings. including... Read More about Pattern-recognition receptor mRNA expression and function in canine monocyte/macrophages and relevance to canine anal furunuclosis.

Risk of anal furunculosis in German Shepherd dogs is associated with the major histocompatibility complex
Journal Article
Kennedy, L. J., O'Neill, T., House, A. K., Barnes, A., Kyostila, K., Innes, J., …Ollier, W. E. R. Risk of anal furunculosis in German Shepherd dogs is associated with the major histocompatibility complex. Tissue Antigens, 71(1), 51-56. https://doi.org/10.1111/j.1399-0039.2007.00964.x

Anal furunculosis (AF) is a chronic, progressive inflammatory disease of the perianal tissues most frequently affecting middle-aged or older German Shepherd dogs (GSD). Because this breed accounts for over 80% of all reported cases, there is likely t... Read More about Risk of anal furunculosis in German Shepherd dogs is associated with the major histocompatibility complex.

Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor
Journal Article
Dutton, L. C., Dudhia, J., Catchpole, B., Hodhkiss-Geere, H., Werling, D., & Connolly, D. J. (in press). Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor. https://doi.org/10.1038/s41598-018-31569-1

derived cells (CDCs) are a cardiac progenitor cell population, which have been shown to possess cardiac regenerative properties and can improve heart function in a variety of cardiac diseases. Studies in large animal models have predominantly focusse... Read More about Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor.