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The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons (2015)
Journal Article
Thorpe, C. T., Godinho, M. S. C., Riley, G. P., Birch, H. L., Clegg, P. D., & Screen, H. R. C. (2015). The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons. Journal of the Mechanical Behavior of Biomedical Materials, 52, 85-94. https://doi.org/10.1016/j.jmbbm.2015.04.009

Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation (2015)
Journal Article
Thorpe, C. T., Chaudhry, S., Lei, I., Varone, A., Riley, G. P., Birch, H. L., Clegg, P. D., & Screen, H. R. (2015). Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation. https://doi.org/10.1111/sms.12333

Tendon injury is thought to involve both damage accumulation within the matrix and an accompanying cell response. While several studies have characterized cell and matrix response in chronically injured tendons, few have assessed the initial response... Read More about Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation.

Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise (2015)
Journal Article
Spiesz, E. M., Thorpe, C. T., Chaudhry, S., Riley, G. P., Birch, H. L., Clegg, P. D., & Screen, H. R. (2015). Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise. Journal of Orthopaedic Research, 33(6), 889-97. https://doi.org/10.1002/jor.22879

The role of inflammation in tendon injury is uncertain and a topic of current interest. In vitro studies of tendon accelerated overload damage can serve as a valuable source of information on the early stages of tendinopathy. Viable fascicle bundles... Read More about Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise.

Proteomic Analysis Reveals Age-related Changes in Tendon Matrix Composition, with Age- and Injury-specific Matrix Fragmentation (2014)
Journal Article
Peffers, M. J., Thorpe, C. T., Collins, J. A., Eong, R., Wei, T. K., Screen, H. R., & Clegg, P. D. (2014). Proteomic Analysis Reveals Age-related Changes in Tendon Matrix Composition, with Age- and Injury-specific Matrix Fragmentation. Journal of Biological Chemistry, 289(37), 25867-78. https://doi.org/10.1074/jbc.M114.566554

Energy storing tendons, such as the human Achilles and equine superficial digital flexor tendon (SDFT), are highly prone to injury, the incidence of which increases with aging. The cellular and molecular mechanisms that result in increased injury in... Read More about Proteomic Analysis Reveals Age-related Changes in Tendon Matrix Composition, with Age- and Injury-specific Matrix Fragmentation.

Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading (2014)
Journal Article
Thorpe, C. T., Riley, G. P., Birch, H. L., Clegg, P. D., & Screen, H. R. C. (2014). Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading. https://doi.org/10.1098/rsif.2013.1058

Some tendons, such as the human Achilles and equine superficial digital flexor tendon (SDFT), act as energy stores, stretching and recoiling to increase efficiency during locomotion. Our previous observations of rotation in response to applied strain... Read More about Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading.