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S1P in the development of atherosclerosis: roles of haemodynamic wall shear stress and endothelial permeability (2021)
Journal Article
Warboys, C. M., & Weinberg, P. D. (2021). S1P in the development of atherosclerosis: roles of haemodynamic wall shear stress and endothelial permeability. Tissue Barriers, https://doi.org/10.1080/21688370.2021.1959243

Atherosclerosis is characterised by focal accumulations of lipid within the arterial wall, thought to arise from effects of haemodynamic wall shear stress (WSS) on endothelial permeability. Identifying pathways that mediate effects of shear on permea... Read More about S1P in the development of atherosclerosis: roles of haemodynamic wall shear stress and endothelial permeability.

β-catenin promotes endothelial survival by regulating eNOS activity and flow-dependent anti-apoptotic gene expression (2020)
Journal Article
Tajadura, V., Hansen, M. H., Smith, J., Charles, H., Rickman, M., Farrell-Dillon, K., Claro, V., Warboys, C., & Ferro, A. (2020). β-catenin promotes endothelial survival by regulating eNOS activity and flow-dependent anti-apoptotic gene expression. Cell Death and Disease, 11(6), https://doi.org/10.1038/s41419-020-2687-6

Increased endothelial cell (EC) apoptosis is associated with the development of atherosclerotic plaques that develop predominantly at sites exposed to disturbed flow (DF). Strategies to promote EC survival may therefore represent a novel therapeutic a... Read More about β-catenin promotes endothelial survival by regulating eNOS activity and flow-dependent anti-apoptotic gene expression.

Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method (2019)
Journal Article
Warboys, C. M., Ghim, M., & Weinberg, P. D. (2019). Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method. Atherosclerosis, 285, 170-177. https://doi.org/10.1016/j.atherosclerosis.2019.04.210

A striking feature of atherosclerosis is its highly non-uniform distribution within the arterial tree. This has been attributed to variation in the haemodynamic wall shear stress (WSS) experienced by endothelial cells, but the WSS characteristics tha... Read More about Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method.

A zebrafish model for functional screening of flow-responsive genes (2017)
Journal Article
Serbanovic-Canic, J., De Luca, A., Warboys, C. M., Hsiao, S., Feng, S., Luong, L., Mahmoud, M., Gauci, I., Ferreira, P., Walczak, H., Firmin, D., Ridger, V., Krams, R., Mason, J. C., Haskard, D. O., Sherwin, S., Chico, T. J. A., & Evans, P. C. (2017). A zebrafish model for functional screening of flow-responsive genes. Arteriosclerosis, Thrombosis, and Vascular Biology, 37, 130-143. https://doi.org/10.1161/ATVBAHA.116.308502

Disturbed flow promotes endothelial senescence via a p53-dependent pathway (2014)
Journal Article
Warboys, C. M., De Luca, A., Amini, N., Luong, L., Duckles, H., Hsiao, S., White, A., Biswas, S., Khamis, R., Chong, C. K., Cheung, W. M., Sherwin, S. J., Bennett, M. R., Gil, J., Mason, J. C., Haskard, D. O., & Evans, P. C. (2014). Disturbed flow promotes endothelial senescence via a p53-dependent pathway. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(5), 985-995. https://doi.org/10.1161/ATVBAHA.114.303415

Although atherosclerosis is associated with systemic risk factors such as age, high cholesterol, and obesity, plaque formation occurs predominately at branches and bends that are exposed to disturbed patterns of blood flow. The molecular mechanisms t... Read More about Disturbed flow promotes endothelial senescence via a p53-dependent pathway.