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Association of the TTN, PDK4, and RNF207 mutations with dilated cardiomyopathy in Dobermanns from the United Kingdom (2025)
Journal Article
Dutton, L., Crossland, A., Dukes-McEwan, J., & Connolly, D. (2025). Association of the TTN, PDK4, and RNF207 mutations with dilated cardiomyopathy in Dobermanns from the United Kingdom. PLoS ONE, 2025 Mar 13;20(3):e0319932, https://doi.org/10.1371/journal.pone.0319932

A missense mutation in the titin gene (TTN) and a splice-site mutation in the pyruvate dehydrogenase kinase 4 gene (PDK4) have been associated with dilated cardiomyopathy (DCM) in Dobermanns from the United States. Additionally, a missense mutation i... Read More about Association of the TTN, PDK4, and RNF207 mutations with dilated cardiomyopathy in Dobermanns from the United Kingdom.

CRISPR/Cas9 gene editing in induced pluripotent stem cells to investigate the feline hypertrophic cardiomyopathy causing MYBPC3/R820W mutation. (2024)
Journal Article
Dutton, L., Dudhia, J., Guest, D., & Connolly, D. (in press). CRISPR/Cas9 gene editing in induced pluripotent stem cells to investigate the feline hypertrophic cardiomyopathy causing MYBPC3/R820W mutation. PLoS ONE, https://doi.org/10.1371/journal.pone.0311761

Hypertrophic cardiomyopathy (HCM) is the most common heart disease in domestic cats, often leading to congestive heart failure and death, with current treatment strategies unable to reverse or prevent progression of the disease. The underlying pathol... Read More about CRISPR/Cas9 gene editing in induced pluripotent stem cells to investigate the feline hypertrophic cardiomyopathy causing MYBPC3/R820W mutation..

Exploration of Mediators Associated with Myocardial Remodelling in Feline Hypertrophic Cardiomyopathy (2023)
Journal Article
Cheng, W.-C., Lawson, C., Liu, H.-H., Wilkie, L., Dobromylskyj, M., Fuentes, V. L., Dudhia, J., & Connolly, D. J. (2023). Exploration of Mediators Associated with Myocardial Remodelling in Feline Hypertrophic Cardiomyopathy. Animals, 13(13), 2112. https://doi.org/10.3390/ani13132112

Simple Summary: The hallmark changes in hypertrophic cardiomyopathy (HCM), a naturally occurring heart disease in both humans and cats, are left ventricular hypertrophy (LVH) and myocardial fibrosis. Key myocardial proteins, lumican, lysyl oxidase (L... Read More about Exploration of Mediators Associated with Myocardial Remodelling in Feline Hypertrophic Cardiomyopathy.

JSAP-2022-0090.R2 Proof Fl (2022)
Journal Article
Berrezaie, M., Connoly, D., Cruzado, J., Mederska, E., Dukes-McEwan, J., & Humm, K. (2022). JSAP-2022-0090.R2 Proof Fl. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13561

Objectives: To determine the causative organisms, clinical features and outcome of 4 canine infective endocarditis (IE) in the UK. 5 6 Methods: Medical records of 3 veterinary referral hospitals were searched for dogs with 7 IE between December 2009... Read More about JSAP-2022-0090.R2 Proof Fl.

Evidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure (2022)
Journal Article
Wilshaw, J., Boswood, A., Chang, Y., Sands, C., Camuzeaux, S., Lewis, M., Xia, D., & Connolly, D. (2022). Evidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure. Metabolomics, 18(6), https://doi.org/10.1007/s11306-022-01887-7

Introduction Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metaboli... Read More about Evidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure.

Clinical features and outcome of dogs and cats with bidirectional and continuous right‐to‐left shunting patent ductus arteriosus (2021)
Journal Article
Greet, V., Bode, E. F., Dukes‐McEwan, J., Oliveira, P., Connolly, D. J., & Sargent, J. (2021). Clinical features and outcome of dogs and cats with bidirectional and continuous right‐to‐left shunting patent ductus arteriosus. Journal of Veterinary Internal Medicine, 35(2), 780-788. https://doi.org/10.1111/jvim.16072

Background: Studies describing the clinical progression of animals with reverse pat

Increased insulin-like growth factor 1 concentrations in a retrospective population of non-diabetic cats diagnosed with hypertrophic cardiomyopathy (2021)
Journal Article
Steele, M. M., Borgeat, K., Payne, J. R., Coss, P., Navarro-Cubas, X., Church, D. B., Niessen, S. J., & Connolly, D. J. (in press). Increased insulin-like growth factor 1 concentrations in a retrospective population of non-diabetic cats diagnosed with hypertrophic cardiomyopathy. Journal of Feline Medicine and Surgery, 1098612X2098799. https://doi.org/10.1177/1098612x20987995

The gut microbiome in dogs with congestive heart failure: a pilot study (2020)
Journal Article
Seo, J., Matthewman, L., Xia, D., Wilshaw, J., Chang, Y., & Connolly, D. (2020). The gut microbiome in dogs with congestive heart failure: a pilot study. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-70826-0

Compromised gut health and dysbiosis in people with heart failure has received a great deal of attention over the last decade. Whether dogs with heart failure have a similar dysbiosis pattern to what is described in people is currently unknown. We hy... Read More about The gut microbiome in dogs with congestive heart failure: a pilot study.

Echocardiographic, morphometric and biomarker changes in female cats followed from 6 to 24 months of life (2020)
Journal Article
van Hoek, I., Laxalde, J., Connolly, D., Rush, J., & Freeman, L. (2020). Echocardiographic, morphometric and biomarker changes in female cats followed from 6 to 24 months of life. Journal of Feline Medicine and Surgery, 1098612X2094368. https://doi.org/10.1177/1098612X20943684

Objectives
The aim of the study was to evaluate cardiac size and early growth through echocardiographic, bodyweight (BW), body condition score (BCS), morphometric and biomarker changes in cats followed from 6 to 24 months of age.

Methods
Twenty-... Read More about Echocardiographic, morphometric and biomarker changes in female cats followed from 6 to 24 months of life.

Inducing pluripotency in the domestic cat (Felis Catus) (2019)
Journal Article
Dutton, L. C., Dudhia, J., Guest, D. J., & Connolly, D. J. (2019). Inducing pluripotency in the domestic cat (Felis Catus). Stem Cells and Development, 28(19), 1299-1309. https://doi.org/10.1089/scd.2019.0142

Domestic cats suffer from a range of inherited genetic diseases, many of which display similarities with equivalent human conditions. Developing cellular models for these inherited diseases would enable drug discovery, benefiting feline health and we... Read More about Inducing pluripotency in the domestic cat (Felis Catus).

Prognostic value of mitral annular systolic plane excursion and tricuspid annular plane systolic excursion in cats with hypertrophic cardiomyopathy (2018)
Journal Article
Spalla, I., Payne, J. R., Borgeat, K. A., Fuentes, V. L., & Connolly, D. J. (2018). Prognostic value of mitral annular systolic plane excursion and tricuspid annular plane systolic excursion in cats with hypertrophic cardiomyopathy. Journal of Veterinary Cardiology, 20(3), 154-164. https://doi.org/10.1016/j.jvc.2018.04.005

Hypertrophic cardiomyopathy (HCM) has a variable prognosis; left atrial size, presence of clinical signs and left ventricular systolic function have been shown to predict outcomes. Mitral annular plane systolic excursion (MAPSE) and tricuspid annular... Read More about Prognostic value of mitral annular systolic plane excursion and tricuspid annular plane systolic excursion in cats with hypertrophic cardiomyopathy.

Inter-observer variability for cardiac ultrasound measurements in cats repeated at different time points in early adult life (2018)
Journal Article
Van Hoek, I., Payne, J. R., Feugier, A., & Connolly, D. J. (2018). Inter-observer variability for cardiac ultrasound measurements in cats repeated at different time points in early adult life. Veterinary and Animal Science, 5, 44-46. https://doi.org/10.1016/j.vas.2018.03.002

Abstract
A high degree of accuracy is required when using echocardiography to diagnose hypertrophic cardiomyopathy (HCM) in cats, as variation in measurements of 0.5 mm may affect classification of individuals as ‘abnormal’. This study in adult cats... Read More about Inter-observer variability for cardiac ultrasound measurements in cats repeated at different time points in early adult life.

Pericardial effusion associated with systemic inflammatory disease in seven dogs (January 2006 – January 2012) (2018)
Journal Article
Covey, H. L., & Connolly, D. J. (2018). Pericardial effusion associated with systemic inflammatory disease in seven dogs (January 2006 – January 2012). Journal of Veterinary Cardiology, 20(2), 123-128. https://doi.org/10.1016/j.jvc.2017.11.002

Pericardial effusion (PE) is reported in dogs as a consequence of neoplasia, primary cardiac disease or as an idiopathic condition. We describe seven dogs with systemic inflammatory disease, PE without tamponade and increased cardiac troponin I conce... Read More about Pericardial effusion associated with systemic inflammatory disease in seven dogs (January 2006 – January 2012).

Transient Myocardial Thickening in Cats Associated with Heart Failure (2017)
Journal Article
Novo Matos, J., Pereira, N., Glaus, T., Wilkie, L., Borgeat, K. A., Loureiro, J., Silva, J., Law, V., Kranjc, A., Connolly, D. J., & Fuentes, V. L. (2017). Transient Myocardial Thickening in Cats Associated with Heart Failure. Journal of Veterinary Internal Medicine, 32(1), 48-56. https://doi.org/10.1111/jvim.14897

Background: Cats with hypertrophic cardiomyopathy (HCM) and congestive heart failure (CHF) can have resolution of both left ventricular hypertrophy and CHF.

Objectives: To describe the clinical characteristics of cats with transient myocardial th... Read More about Transient Myocardial Thickening in Cats Associated with Heart Failure.

Investigations into the Sarcomeric Protein and Ca2+-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus). (2017)
Journal Article
Messer, A. E., Chan, J., Daley, A., Copeland, O., Marston, S. B., & Connolly, D. J. (2017). Investigations into the Sarcomeric Protein and Ca2+-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus). Frontiers in Physiology, 8, 348. https://doi.org/10.3389/fphys.2017.00348

Hypertrophic cardiomyopathy (HCM) is the most common single gene inherited cardiomyopathy. In cats (Felix catus) HCM is even more prevalent and affects 16% of the outbred population and up to 26% in pedigree breeds such as Maine Coon and Ragdoll. Hom... Read More about Investigations into the Sarcomeric Protein and Ca2+-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus)..

Differentiation of Cardiac from Noncardiac Pleural Effusions in Cats using Second-Generation Quantitative and Point-of-Care NT-proBNP Measurements (2016)
Journal Article
Hezzell, M. J., Rush, J. E., Humm, K. R., Rozanski, E. A., Sargent, J., Connolly, D. J., Boswood, A., & Oyama, M. A. (2016). Differentiation of Cardiac from Noncardiac Pleural Effusions in Cats using Second-Generation Quantitative and Point-of-Care NT-proBNP Measurements. Journal of Veterinary Internal Medicine, 30(2), 536-542. https://doi.org/10.1111/jvim.13831