Theileria Apicoplast as a Target for Chemotherapy

Lizundia, R; Werling, D; Langsley, G; Ralph, S A

doi:10.1128/aac.00126-08

POLYMORPHISMS IN TOLL-LIKE RECEPTOR 5 RESULT IN HYPER-RESPONSIVENESS TO FLAGELLIN
Presentation / Conference Contribution
Kathrani, A., Werling, D., Holder, A. L., Catchpole, B., & Allenspach, K. POLYMORPHISMS IN TOLL-LIKE RECEPTOR 5 RESULT IN HYPER-RESPONSIVENESS TO FLAGELLIN

Characterisation of antibodies to bovine toll-like receptor (TLR)-2 and cross-reactivity with ovine TLR2
Journal Article
Kwong, L. S., Parsons, R., Patterson, R., Coffey, T. J., Thonur, L., Chang, J., Russell, G., Haig, D., Werling, D., & Hope, J. C. Characterisation of antibodies to bovine toll-like receptor (TLR)-2 and cross-reactivity with ovine TLR2. Veterinary Immunology and Immunopathology, 139(2-4), 313-318. https://doi.org/10.1016/j.vetimm.2010.10.014

Evaluation of mucosal bacteria and histopathology, clinical disease activity and expression of Toll-like receptors in German shepherd dogs with chronic enteropathies
Journal Article
Allenspach, K., House, A., Smith, K., McNeill, F. M., Hendricks, A., Elson-Riggins, J. G., Riddle, A. L., Steiner, J. M., Werling, D., Garden, O. A., Catchpole, B., & Suchodolski, J. S. Evaluation of mucosal bacteria and histopathology, clinical disease activity and expression of Toll-like receptors in German shepherd dogs with chronic enteropathies. Veterinary Microbiology, 146(3-4), 326-335. https://doi.org/10.1016/j.vetmic.2010.05.025

Primary bovine colonic cells: A model to study strain-specific responses to Escherichia coli
Journal Article
Bridger, P. S., Mohr, M., Stamm, I., Frohlich, J., Follmann, W., Birkner, S., Metcalfe, H., Werling, D., Baljer, G., & Menge, C. Primary bovine colonic cells: A model to study strain-specific responses to Escherichia coli. Veterinary Immunology and Immunopathology, 137(1-2), 54-63. https://doi.org/10.1016/j.vetimm.2010.04.010

TGF-b2 induction regulates invasiveness of Theileria-Transformed Leukocytes and Disease susceptibility
Journal Article
Chaussepied, M., Janski, N., Baumgartner, M., Lizundia, R., Jensen, K., Weri, W., Shiels, B. R., Weitzmn, J. B., Glass, E. J., Werling, D., & Langsley, G. TGF-b2 induction regulates invasiveness of Theileria-Transformed Leukocytes and Disease susceptibility. PLoS Pathogens, 6(11), e1001197. https://doi.org/10.1371/journal.ppat.1001197

Evaluation of the effect of phosphodiesterase on equine platelet activation and the effect of antigen challenge on platelet phosphodiesterase activity in horses with recurrent airway obstruction
Journal Article
Dunkel, B., Rickards, K. J., Werling, D., Page, C. P., & Cunningham, F. M. Evaluation of the effect of phosphodiesterase on equine platelet activation and the effect of antigen challenge on platelet phosphodiesterase activity in horses with recurrent airway obstruction. American Journal of Veterinary Research, 71(5), 534-540. https://doi.org/10.2460/ajvr.71.5.534

Regulation of equine platelet activation by phosphodiesterase (PDE) and the effect of antigen challenge on platelet PDE in horses with recurrent airway obstruction (RAO)
Journal Article
Dunkel, B., Rickards, K. J., Werling, D., Page, C. P., & Cunningham, F. M. Regulation of equine platelet activation by phosphodiesterase (PDE) and the effect of antigen challenge on platelet PDE in horses with recurrent airway obstruction (RAO). American Journal of Veterinary Research, 71(5), 534-540. https://doi.org/10.2460/ajvr.71.5.534

Polymorphisms in the TLR4 and TLR5 gene are significantly associated with inflammatory bowel disease in German shepherd dogs.
Journal Article
Kathrani, A., House, A. K., Catchpole, B., Murphy, A., German, A., Werling, D., & Allenspach, K. Polymorphisms in the TLR4 and TLR5 gene are significantly associated with inflammatory bowel disease in German shepherd dogs. PLoS ONE, 5(12), e15740. https://doi.org/10.1371/journal.pone.0015740

OVERDOMINANT SINGLE NUCLEOTIDE POLYMORPHISMS IN THE NUCLEOTIDE OLIGOMERISATION DOMAIN TWO (NOD2) GENE ARE SIGNIFICANTLY ASSOCIATED WITH CANINE INFLAMMATORY BOWEL DISEASE
Presentation / Conference Contribution
Kathrani, A., House, A. K., Werling, D., Catchpole, B., Murphy, A., German, A. J., Lee, H., & Allenspach, K. OVERDOMINANT SINGLE NUCLEOTIDE POLYMORPHISMS IN THE NUCLEOTIDE OLIGOMERISATION DOMAIN TWO (NOD2) GENE ARE SIGNIFICANTLY ASSOCIATED WITH CANINE INFLAMMATORY BOWEL DISEASE

CD11c POSITIVE DENDRITIC CELLS ARE SIGNIFICANTLY DECREASED IN THE DUODENUM OF DOGS WITH INFLAMMATORY BOWEL DISEASE
Presentation / Conference Contribution
Kathrani, A., House, A., Werling, D., Smith, K. C., Garden, O. A., Simbi, B. H., & Allenspach, K. CD11c POSITIVE DENDRITIC CELLS ARE SIGNIFICANTLY DECREASED IN THE DUODENUM OF DOGS WITH INFLAMMATORY BOWEL DISEASE

Expression of Toll-like receptor 2 in duodenal biopsies from dogs with inflammatory bowel disease is associated with severity of disease
Journal Article
McMahon, L. A., House, A., Catchpole, B., Elson-Riggins, J. G., Riddle, A. L., Smith, K. C., Werling, D., Burgener, I. A., & Allenspach, K. Expression of Toll-like receptor 2 in duodenal biopsies from dogs with inflammatory bowel disease is associated with severity of disease. Veterinary Immunology and Immunopathology, 135(1-2), 158-163. https://doi.org/10.1016/j.vetimm.2009.11.012

Flagellin expression enhances Salmonella accumulation in TLR5-positive macrophages
Journal Article
Metcalfe, H. J., Best, A., Kanellos, T., La Radione, R. M., & Werling, D. Flagellin expression enhances Salmonella accumulation in TLR5-positive macrophages. Developmental and Comparative Immunology, 34(8), 797-804. https://doi.org/10.1016/j.dci.2010.02.008

LRRfinder: a web application for the identification of leucine-rich repeats and an integrative Toll-like receptor database
Journal Article
Offord, V., Coffey, T. J., & Werling, D. LRRfinder: a web application for the identification of leucine-rich repeats and an integrative Toll-like receptor database. Developmental and Comparative Immunology, 34(10), 1035-1041. https://doi.org/10.1016/j.dci.2010.05.004

The bovine chemokine receptors and their mRNA abundance in mononuclear phagocytes
Journal Article
Widdison, S., Siddiqui, N., Easton, V., Lawrence, F., Ashley, G., Werling, D., Watson, M., & Coffey, T. The bovine chemokine receptors and their mRNA abundance in mononuclear phagocytes. BMC Genomics, 11(439), https://doi.org/10.1186/1471-2164-11-439

Prevalence of endemic pig diseases in England: an overview six months into a large-scale cross-sectional study on Post-Weaning Multi-systemic Wasting Syndrome (PMWS)
Journal Article
Wieland, B., Alarcon, P., Velasova, M., Nevel, M., Towrie, H., Pfeiffer, D. U., Wathes, C. M., & Werling, D. Prevalence of endemic pig diseases in England: an overview six months into a large-scale cross-sectional study on Post-Weaning Multi-systemic Wasting Syndrome (PMWS)

WC1(+)gamma delta T Cells Indirectly Regulate Chemokine Production During Mycobacterium bovis Infection in SCID-bo Mice
Journal Article
Alvarez, A. J., Endsley, J. J., Werling, D., & Estes, D. M. WC1(+)gamma delta T Cells Indirectly Regulate Chemokine Production During Mycobacterium bovis Infection in SCID-bo Mice. Transboundary and Emerging Diseases, 56(6-7), 275-284. https://doi.org/10.1111/j.1865-1682.2009.01081.x

Molecular cloning and characterization of Toll-like receptors 1-10 in sheep
Journal Article
Chang, J. S., Russell, G. C., Jann, O. C., Glass, E. J., Werling, D., & Haig, D. Molecular cloning and characterization of Toll-like receptors 1-10 in sheep. Veterinary Immunology and Immunopathology, 127(1-2), 94-105. https://doi.org/10.1016/j.vetimm.2008.09.026

Toll-like receptors (TLRs) are pattern-recognition receptors that trigger innate immune responses and stimulate adaptive immunity. Currently, only partial information is available for sheep TLR genes. The aims of this study were to clone and sequence... Read More about Molecular cloning and characterization of Toll-like receptors 1-10 in sheep.

TB or not TB: A Disease Forgotten, but not Gone
Journal Article
Coffey, T. J., & Werling, D. TB or not TB: A Disease Forgotten, but not Gone. Transboundary and Emerging Diseases, 56(6-7), 203-203

Neutrophil and platelet activation in equine recurrent airway obstruction is associated with increased neutrophil CD13 expression, but not platelet CD41/61 and CD62P or neutrophil-platelet aggregate formation
Journal Article
Dunkel, B., Rickards, K. J., Werling, D., Page, C. P., & Cunningham, F. M. Neutrophil and platelet activation in equine recurrent airway obstruction is associated with increased neutrophil CD13 expression, but not platelet CD41/61 and CD62P or neutrophil-platelet aggregate formation. Veterinary Immunology and Immunopathology, 131(1-2), 25-32. https://doi.org/10.1016/j.vetimm.2009.03.004

Theileria Apicoplast as a Target for Chemotherapy
Journal Article
Lizundia, R., Werling, D., Langsley, G., & Ralph, S. A. Theileria Apicoplast as a Target for Chemotherapy. Antimicrobial Agents and Chemotherapy, 53(3), 1213-1217. https://doi.org/10.1128/aac.00126-08

Theileria parasites cause severe bovine disease and death in a large part of the world. These apicomplexan parasites possess a relic plastid (apicoplast), whose metabolic pathways include several promising drug targets. Putative inhibitors of these t... Read More about Theileria Apicoplast as a Target for Chemotherapy.

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