All Outputs (25)

DEVELOPING, TESTING AND OPTIMISING A MOUSE HINDLIMB MUSCULOSKELETAL MODEL (2015)
Presentation / Conference Contribution
Charles, J. P., Cappellari, O., Spence, A., Wells, D. J., & Hutchinson, J. R. DEVELOPING, TESTING AND OPTIMISING A MOUSE HINDLIMB MUSCULOSKELETAL MODEL

Stability during locomotion arises from many complex interactions which are not yet fully understood. Studies into how sensory feedback from muscle spindles contributes to this have used neuromechanical simulations, however their accuracy is limited... Read More about DEVELOPING, TESTING AND OPTIMISING A MOUSE HINDLIMB MUSCULOSKELETAL MODEL.

MOVING FORWARD WITH TACT: 2 YEARS ON
Presentation / Conference Contribution
Heslop, E., Bushby, K., Csimma, C., Straub, V., & Wells, D. J. MOVING FORWARD WITH TACT: 2 YEARS ON

MAKING SENSE IN DUCHENNE MUSCULAR DYSTROPHY
Presentation / Conference Contribution
Wells, D. J. MAKING SENSE IN DUCHENNE MUSCULAR DYSTROPHY

MDX MICE SHOW CHANGES IN MUSCLE FIBER PROFILE NUMBER WITH AGE
Presentation / Conference Contribution
Terry, R. L., Hasan, N., & Wells, D. J. MDX MICE SHOW CHANGES IN MUSCLE FIBER PROFILE NUMBER WITH AGE

ASSESSING THE THERAPEUTIC POTENTIAL OF LARGE IN A NEW MOUSE MODEL OF DYSTROGLYCANOPATHY
Presentation / Conference Contribution
Whitmore, C., Ackroyd, M. R., Muses, S., Ashraf, A., Muntoni, F., Brown, S. C., & Wells, D. J. ASSESSING THE THERAPEUTIC POTENTIAL OF LARGE IN A NEW MOUSE MODEL OF DYSTROGLYCANOPATHY

OUTCOME MEASURES IN THE MDX MOUSE
Presentation / Conference Contribution
Wells, D. J. OUTCOME MEASURES IN THE MDX MOUSE

ARE LARGE-IN-FRAME DUPLICATIONS OF DYSTROPHIN FUNCTIONAL?
Presentation / Conference Contribution
Muses, S., Jones, H., & Wells, D. J. ARE LARGE-IN-FRAME DUPLICATIONS OF DYSTROPHIN FUNCTIONAL?

EXON SKIPPING AND DYSTROPHIN RESTORATION IN DUCHENNE MUSCULAR DYSTROPHY PATIENTS AFTER SYSTEMIC PHOSPHORODIAMIDATE MORPHOLINO OLIGOMER TREATMENT
Presentation / Conference Contribution
Cirak, S., Arechavala-Gomeza, V., Guglieri, M., Feng, L., Torelli, S., Anthony, K., Garralda, M. E., Wells, D. J., Dickson, G., Wood, M. J. A., Wilton, S. D., Straub, V., Shrewsbury, S. B., Sewry, C., Morgan, J. E., Bushby, K., & Muntoni, F. EXON SKIPPING AND DYSTROPHIN RESTORATION IN DUCHENNE MUSCULAR DYSTROPHY PATIENTS AFTER SYSTEMIC PHOSPHORODIAMIDATE MORPHOLINO OLIGOMER TREATMENT

ASSESSING THE LONG TERM EXPRESSION OF LARGE AS A POTENTIAL THERAPY IN A MOUSE MODEL OF LGMD2I
Presentation / Conference Contribution
Whitmore, C., Booler, H., Parr, C., Ackroyd, M. R., Fernandez-Fuente, M., Muntoni, F., Wells, D., & Brown, S. C. ASSESSING THE LONG TERM EXPRESSION OF LARGE AS A POTENTIAL THERAPY IN A MOUSE MODEL OF LGMD2I

OVER EXPRESSION OF THE LARGE TRANSGENE EXACERBATES MUSCLE PATHOLOGY IN THE MDX MOUSE
Presentation / Conference Contribution
Wells, K. E., Muses, S., Ruberg, A., Terry, R., Shihab, N. K., & Wells, D. J. OVER EXPRESSION OF THE LARGE TRANSGENE EXACERBATES MUSCLE PATHOLOGY IN THE MDX MOUSE

TREATMENT WITH ORAL METFORMIN IMPROVES MUSCLE FUNCTION IN MDX MICE
Presentation / Conference Contribution
Terry, R. L., & Wells, D. J. TREATMENT WITH ORAL METFORMIN IMPROVES MUSCLE FUNCTION IN MDX MICE

POLOXOMER 188 HAS A DELETERIOUS EFFECT ON SKELETAL MUSCLE FUNCTION IN THE MDX MOUSE
Presentation / Conference Contribution
Terry, R. L., Kaneb, H. M., & Wells, D. J. POLOXOMER 188 HAS A DELETERIOUS EFFECT ON SKELETAL MUSCLE FUNCTION IN THE MDX MOUSE

INVESTIGATING THE EFFECTS OF DAO TRANSGENES ON THE SOD1(G93A) MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Presentation / Conference Contribution
Rahmani-Kondori, N., de Belleroche, J., & Wells, D. J. INVESTIGATING THE EFFECTS OF DAO TRANSGENES ON THE SOD1(G93A) MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)

RESTORING THE READING FRAME IN LARGE DMD DUPLICATION MUTATIONS RESULTS IN DYSTROPHIN EXPRESSION IN VIVO
Presentation / Conference Contribution
Muses, S., Jones, H., & Wells, D. J. RESTORING THE READING FRAME IN LARGE DMD DUPLICATION MUTATIONS RESULTS IN DYSTROPHIN EXPRESSION IN VIVO

GENERATION OF THREE-DIMENSIONAL HUMAN ARTIFICIAL SKELETAL MUSCLE TISSUE FROM IPS CELLS ENABLES COMPLEX DISEASE MODELLING FOR MUSCULAR DYSTROPHY
Presentation / Conference Contribution
Maffioletti, S. M., Sarcar, S., Henderson, A., Mannhardt, I., Pinton, L., Moyle, L. A., Steele-Stallard, H., Cappellari, O., Wells, K. E., Ragazzi, M., Wang, W., Zammit, P., Wells, D. J., Eschenhagen, T., & Tedesco, F. S. GENERATION OF THREE-DIMENSIONAL HUMAN ARTIFICIAL SKELETAL MUSCLE TISSUE FROM IPS CELLS ENABLES COMPLEX DISEASE MODELLING FOR MUSCULAR DYSTROPHY

MUSCLE PHYSIOLOGY PROPERTIES OF MOUSE MODELS FOR DUCHENNE MUSCULAR DYSTROPHY
Presentation / Conference Contribution
van Putten, M., Terry, R., Hulsker, M., Wells, K. E., Aartsma-Rus, A., & Wells, D. J. MUSCLE PHYSIOLOGY PROPERTIES OF MOUSE MODELS FOR DUCHENNE MUSCULAR DYSTROPHY

PEPTIDE-PMO INDUCED EXON-SKIPPING RESTORES MUSCLE PHYSIOLOGY IN THE MDX MOUSE
Presentation / Conference Contribution
Wells, K. E., Muses, S., Terry, R. L., Wood, M. J., Gait, M. J., & Wells, D. J. PEPTIDE-PMO INDUCED EXON-SKIPPING RESTORES MUSCLE PHYSIOLOGY IN THE MDX MOUSE

ASSESSMENT OF NEUROMUSCULAR JUNCTION ABNORMALITIES INDUCED BY ALPHA-DYSTROGLYCAN GLYCOSYLATION DEFECTS
Presentation / Conference Contribution
Fernandez-Fuente, M., Kim, J., Wells, D. J., & Brown, S. C. ASSESSMENT OF NEUROMUSCULAR JUNCTION ABNORMALITIES INDUCED BY ALPHA-DYSTROGLYCAN GLYCOSYLATION DEFECTS

MUSCLE PHYSIOLOGY PROPERTIES OF MOUSE MODELS FOR DUCHENNE MUSCULAR DYSTROPHY
Presentation / Conference Contribution
van Putten, M., Terry, R. L., Hulsker, M., Wells, K. E., Aartsma-Rus, A., & Wells, D. J. MUSCLE PHYSIOLOGY PROPERTIES OF MOUSE MODELS FOR DUCHENNE MUSCULAR DYSTROPHY

Report of the 2013 RSPCA/UFAW Rodent Welfare Group Meeting
Presentation / Conference Contribution
Hawkins, P., Littlefair, P., Gollege, H., Richardson, C., Allden, S., Boden, T., Hendrie, C., Wells, D. J., Osborne, N., Hutchinson, M., Ryder, S., Jennings, M., & Hubrecht, R. Report of the 2013 RSPCA/UFAW Rodent Welfare Group Meeting