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MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1
Journal Article
Yamamoto, K., Okano, H., Miyagawa, W., Visse, R., Shitomi, Y., Santamaria, S., Dudhia, J., Troeberg, L., Strickland, D. K., Hirohata, S., & Nagase, H. (in press). MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1. Matrix Biology, 56, 57-73. https://doi.org/10.1016/j.matbio.2016.03.007

Age-related changes in the response of human articular cartilage to IL-1 alpha and transforming growth factor-beta (TGF-beta) - Chondrocytes exhibit a diminished sensitivity to TGF-beta
Journal Article
Hickery, M. S., Bayliss, M. T., Dudhia, J., Lewthwaite, J. C., Edwards, J. C. W., & Pitsillides, A. A. Age-related changes in the response of human articular cartilage to IL-1 alpha and transforming growth factor-beta (TGF-beta) - Chondrocytes exhibit a diminished sensitivity to TGF-beta. Journal of Biological Chemistry, 278(52), 53063-53071. https://doi.org/10.1074/jbc.M209632200

JAK/STAT BUT NOT ERK1/ERK2 PATHWAY MEDIATES INTERLEUKIN (IL)-6/SOLUBLE IL-6R DOWN-REGULATION OF TYPE II COLLAGEN, AGGRECAN CORE, AND LINK PROTEIN TRANSCRIPTION IN ARTICULAR CHONDROCYTES - ASSOCIATION WITH A DOWN-REGULATION OF SOX9 EXPRESSION
Presentation / Conference Contribution
Legendre, F., Dudhia, J., Pujol, J. P., & Bogdanowicz, P. JAK/STAT BUT NOT ERK1/ERK2 PATHWAY MEDIATES INTERLEUKIN (IL)-6/SOLUBLE IL-6R DOWN-REGULATION OF TYPE II COLLAGEN, AGGRECAN CORE, AND LINK PROTEIN TRANSCRIPTION IN ARTICULAR CHONDROCYTES - ASSOCIATION WITH A DOWN-REGULATION OF SOX9 EXPRESSION

Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican - Formation of ternary complexes with defined hyaluronan oligosaccharides
Journal Article
Seyfried, N. T., McVey, G. F., Almond, A., Mahoney, D. J., Dudhia, J., & Day, A. J. Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican - Formation of ternary complexes with defined hyaluronan oligosaccharides. Journal of Biological Chemistry, 280(7), 5435-5448

Modification of the Composition of Articular Cartilage Collagen Fibrils with Increasing Age
Journal Article
Vaughan-Thomas, A., Dudhia, J., Bayliss, M., Kadler, K., & Duance, V. Modification of the Composition of Articular Cartilage Collagen Fibrils with Increasing Age. Connective Tissue Research, 49(5), 374-382. https://doi.org/10.1080/03008200802325417

Recent studies have identified a range of interactions between type IX collagen and other cartilage matrix components. To determine the extent to which these interactions are important in maintaining the integrity of ageing articular cartilage, we an... Read More about Modification of the Composition of Articular Cartilage Collagen Fibrils with Increasing Age.

Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor
Journal Article
Dutton, L. C., Dudhia, J., Catchpole, B., Hodhkiss-Geere, H., Werling, D., & Connolly, D. J. (in press). Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor. https://doi.org/10.1038/s41598-018-31569-1

derived cells (CDCs) are a cardiac progenitor cell population, which have been shown to possess cardiac regenerative properties and can improve heart function in a variety of cardiac diseases. Studies in large animal models have predominantly focusse... Read More about Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor.