Skip to main content

Research Repository

Advanced Search

All Outputs (98)

Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018 (2020)
Journal Article
Catalano, S., Léger, E., Fall, C. B., Borlase, A., Diop, S. D., Berger, D., Webster, B. L., Faye, B., Diouf, N. D., Rollinson, D., Sène, M., Bâ, K., & Webster, J. P. (2020). Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018. Emerging Infectious Disease, 26(6), https://doi.org/10.3201/eid2606.200107

In West Africa, Schistosoma spp. are capable of infecting multiple definitive hosts, a lifecycle feature that may complicate schistosomiasis control. We characterized the evolutionary relationships among multiple Schistosoma mansoni isolates collecte... Read More about Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018.

Toward Improving Interventions Against Toxoplasmosis by Identifying Routes of Transmission Using Sporozoite- specific Serological Tools (2020)
Journal Article
Walker, M., Webster, J. P., & Milne, G. (2020). Toward Improving Interventions Against Toxoplasmosis by Identifying Routes of Transmission Using Sporozoite- specific Serological Tools. Clinical Infectious Diseases, https://doi.org/10.1093/cid/ciaa428

Background. Horizontal transmission of Toxoplasma gondii occurs primarily via ingestion of environmental oocysts or con- sumption of undercooked/raw meat containing cyst-stage bradyzoites. The relative importance of these 2 transmission routes remain... Read More about Toward Improving Interventions Against Toxoplasmosis by Identifying Routes of Transmission Using Sporozoite- specific Serological Tools.

Divergence across mitochondrial genomes of sympatric members of the Schistosoma indicum group and clues into the evolution of Schistosoma spindale (2020)
Journal Article
Jones, B. P., Norman, B. F., Borrett, H. E., Attwood, S. W., Mondal, M. M. H., Walker, A. J., Webster, J. P., Jayanthe Rajapakse, P. R. V., & Lawton, S. P. (2020). Divergence across mitochondrial genomes of sympatric members of the Schistosoma indicum group and clues into the evolution of Schistosoma spindale. https://doi.org/10.1038/s41598-020-57736-x

Schistosoma spindale and Schistosoma indicum are ruminant-infecting trematodes of the Schistosoma indicum group that are widespread across Southeast Asia. Though neglected, these parasites can cause major pathology and mortality to livestock leading... Read More about Divergence across mitochondrial genomes of sympatric members of the Schistosoma indicum group and clues into the evolution of Schistosoma spindale.

Two-year longitudinal survey reveals high genetic diversity of Schistosoma mansoni with adult worms surviving praziquantel treatment at the start of mass drug administration in Uganda (2019)
Journal Article
Faust, C. L., Crotti, M., Moses, A., Oguttu, D., Wamboko, A., Adriko, M., Adekanle, E. K., Kabatereine, N., Tukahebwa, E. M., Norton, A. J., Gower, C. M., Webster, J. P., & Lamberton, P. H. L. (2019). Two-year longitudinal survey reveals high genetic diversity of Schistosoma mansoni with adult worms surviving praziquantel treatment at the start of mass drug administration in Uganda. https://doi.org/10.1186/s13071-019-3860-6

Schistosomiasis — Assessing Progress toward the 2020 and 2025 Global Goals (2019)
Journal Article
Deol, A. K., Fleming, F. M., Calvo-Urbano, B., Walker, M., Bucumi, V., Gnandou, I., Tukahebwa, E. M., Jemu, S., Mwingira, U. J., Alkohlani, A., Traoré, M., Ruberanziza, E., Touré, S., Basáñez, M.-G., French, M. D., & Webster, J. P. (2019). Schistosomiasis — Assessing Progress toward the 2020 and 2025 Global Goals. New England Journal of Medicine, 381, 2519-2528. https://doi.org/10.1056/NEJMoa1812165

Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission (2019)
Journal Article
Wood, C. L., Sokolow, S. H., Jones, I. J., Chamberlin, A. J., Lafferty, K. D., Kuris, A. M., Jocque, M., Hopkins, S., Adams, G., Buck, J. C., Lund, A. J., Garcia-vedreene, A. E., Fiorenza, E., Rohr, J. R., Allan, F., Webster, B., Rabone, M., Webster, J. P., Bandagny, L., Ndione, R., …De Leo, G. A. (2019). Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission. Proceedings of the National Academy of Sciences, 116(46), 23182-23191. https://doi.org/10.1073/pnas.1903698116

Recently, the World Health Organization recognized that efforts to interrupt schistosomiasis transmission through mass drug administration have been ineffective in some regions; one of their new recommended strategies for global schistosomiasis contr... Read More about Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission.

Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing (2019)
Journal Article
Doyle, S. R., Sankaranarayanan, G., Allan, F., Berger, D., Jimenez Castro, P. D., Collins, J. B., Crellen, T., Duque-Correa, M. A., Ellis, P., Jaleta, T. G., Laing, R., Maitland, K., McCarthy, C., Moundai, T., Softley, B., Thiele, E., Ouakou, P. T., Tushabe, J. V., Webster, J. P., Weiss, A. J., …Holroyd, N. (2019). Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing. Frontiers in Genetics, 10, https://doi.org/10.3389/fgene.2019.00826

Whole-genome sequencing is being rapidly applied to the study of helminth genomes, including de novo genome assembly, population genetics, and diagnostic applications. Although late-stage juvenile and adult parasites typically produce sufficient DNA... Read More about Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing.

Mini-FLOTAC as an alternative, non-invasive diagnostic tool for Schistosoma mansoni and other trematode infections in wildlife reservoirs (2019)
Journal Article
Catalano, S., Symeou, A., Marsh, K. J., Borlase, A., Léger, E., Fall, C. B., Sène, M., Diouf, N. D., Ianniello, D., Cringoli, G., Rinaldi, L., Bâ, K., & Webster, J. P. (2019). Mini-FLOTAC as an alternative, non-invasive diagnostic tool for Schistosoma mansoni and other trematode infections in wildlife reservoirs. https://doi.org/10.1186/s13071-019-3613-6

Schistosomiasis and food-borne trematodiases are not only of major public health concern, but can also have profound implications for livestock production and wildlife conservation. The zoonotic, multi-host nature of many digenean trematodes is a sig... Read More about Mini-FLOTAC as an alternative, non-invasive diagnostic tool for Schistosoma mansoni and other trematode infections in wildlife reservoirs.

The association between child Schistosoma spp. infections and morbidity in an irrigated rice region in Mali: a localized study (2019)
Journal Article
Mutombo, N., Landouré, A., Young Man, W., Fenwick, A., Dembélé, R., Sacko, M., Keita, A. D., Traoré, M. S., Webster, J. P., & McLaws, M.-L. (2019). The association between child Schistosoma spp. infections and morbidity in an irrigated rice region in Mali: a localized study. Acta Tropica, 199, https://doi.org/10.1016/j.actatropica.2019.105115

Schistosomiasis is one of the neglected tropical diseases endemic to Mali. There has been insufficient investigation of the morbidity burden in highly endemic irrigated rice areas with the ongoing mass drug administration with praziquantel. In Februa... Read More about The association between child Schistosoma spp. infections and morbidity in an irrigated rice region in Mali: a localized study.

Population genetics of Oncomelania hupensis snails, intermediate hosts of Schistosoma japonium, from emerging, re-emerging or established habitats within China (2019)
Journal Article
Qiu, C., Lu, D.-B., Deng, Y., Zou, H.-Y., Liang, Y.-S., & Webster, J. P. (2019). Population genetics of Oncomelania hupensis snails, intermediate hosts of Schistosoma japonium, from emerging, re-emerging or established habitats within China. Acta Tropica, 197, 105048. https://doi.org/10.1016/j.actatropica.2019.105048

Schistosomiasis remains one of the world’s most significant neglected tropical diseases, second only to malaria in terms of socioeconomic impact. In 2014, China proposed the goal of schistosomiasis japonicum elimination by 2025. However, one major ch... Read More about Population genetics of Oncomelania hupensis snails, intermediate hosts of Schistosoma japonium, from emerging, re-emerging or established habitats within China.

Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole genome sequencing (2019)
Journal Article
Doyle, S. R., Sankaranarayan, G., Berger, D., Jimenez Castro, P. D., Collins, J. B., Crellen, T., Duque-Correa, M. A., Ellis, P., Jaleta, T. G., Laing, R., Maitland, K., McCarthy, C., Moundai, T., Softley, B., Thiele, E., Tchindebet Ouakou, P., Tushabe, J. V., Webster, J. P., Weiss, A. J., Lok, J., …Holroyd, N. (2019). Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole genome sequencing. https://doi.org/10.1101/616672

Uncooked fish consumption among those at risk of Opisthorchis viverrini infection in central Thailand (2019)
Journal Article
Suwannahitatorn, P., Webster, J. P., Riley, S., Mungthin, M., & Donnelly, C. A. (2019). Uncooked fish consumption among those at risk of Opisthorchis viverrini infection in central Thailand. PLoS ONE, 14(1), e0211540. https://doi.org/10.1371/journal.pone.0211540

In contrast to northern and northeastern Thailand, central Thailand was believed not to be endemic for Opisthorchis viverrini (OV). Fieldwork conducted in a rural area of central Thailand revealed that the prevalence and incidence were relatively hig... Read More about Uncooked fish consumption among those at risk of Opisthorchis viverrini infection in central Thailand.

Rodents of Senegal and their role as intermediate hosts of Hydatigera spp. (Cestoda: Taeniidae) (2018)
Journal Article
Catalano, S., Bâ, K., Diouf, N., Léger, E., Verocai, G., & Webster, J. P. (2018). Rodents of Senegal and their role as intermediate hosts of Hydatigera spp. (Cestoda: Taeniidae). Parasitology, 146(3), 299-304. https://doi.org/10.1017/S0031182018001427

Hydatigera (Cestoda: Taeniidae) is a recently resurrected genus including species seldom investigated in sub-Saharan Africa. We surveyed wild small mammal populations in the areas of Richard Toll and Lake Guiers, Senegal, with the objective to evalua... Read More about Rodents of Senegal and their role as intermediate hosts of Hydatigera spp. (Cestoda: Taeniidae).

Phylogenetic relationships within the Opisthorchis viverrini species complex with specific analysis of O. viverrini sensu lato from Sakon Nakhon, Thailand by mitochondrial and nuclear DNA sequencing (2018)
Journal Article
Pitaksakulrat, O., Webster, B. L., Webster, J. P., Laha, T., Saijuntha, W., Lamberton, P. H. L., Kiatsopit, N., Andrews, R. H., Petney, T. N., & Sithithaworn, P. (2018). Phylogenetic relationships within the Opisthorchis viverrini species complex with specific analysis of O. viverrini sensu lato from Sakon Nakhon, Thailand by mitochondrial and nuclear DNA sequencing. https://doi.org/10.1016/j.meegid.2018.04.022

The liver fluke Opisthorchis viverrini sensu lato causes serious public-health problems in Northeast Thailand and Southeast Asian countries. A hypothesis has been proposed that O. viverrini represents a species complex with varying levels of genetic... Read More about Phylogenetic relationships within the Opisthorchis viverrini species complex with specific analysis of O. viverrini sensu lato from Sakon Nakhon, Thailand by mitochondrial and nuclear DNA sequencing.

Opportunities and challenges for modelling epidemiological and evolutionary dynamics in a multihost, multiparasite system: Zoonotic hybrid schistosomiasis in West Africa (2018)
Journal Article
Borlase, A., Webster, J. P., & Rudge, J. W. (2018). Opportunities and challenges for modelling epidemiological and evolutionary dynamics in a multihost, multiparasite system: Zoonotic hybrid schistosomiasis in West Africa. Evolutionary Applications, 11(4), 501-515. https://doi.org/10.1111/eva.12529

Multihost multiparasite systems are evolutionarily and ecologically dynamic, which presents substantial trans‐disciplinary challenges for elucidating their epidemiology and designing appropriate control. Evidence for hybridizations and introgressions... Read More about Opportunities and challenges for modelling epidemiological and evolutionary dynamics in a multihost, multiparasite system: Zoonotic hybrid schistosomiasis in West Africa.

The effects of subcurative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni (2018)
Journal Article
Viana, M., Faust, C. L., Haydon, D. T., Webster, J. P., & Lamberton, P. H. L. (2018). The effects of subcurative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni. Evolutionary Applications, 11(3), 488-500. https://doi.org/10.1111/eva.12558

Natural selection acts on all organisms, including parasites, to maximize reproductive fitness. Drug resistance traits are often associated with life-history costs in the absence of treatment. Schistosomiasis control programmes rely on mass drug admi... Read More about The effects of subcurative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni.

Rodents as natural hosts of zoonotic Schistosoma species and hybrids: an epidemiological and evolutionary perspective from West Africa (2018)
Journal Article
Catalano, S., Sène, M., Diouf, N. D., Fall, C. B., Borlase, A., Léger, E., Bâ, K., & Webster, J. P. (2018). Rodents as natural hosts of zoonotic Schistosoma species and hybrids: an epidemiological and evolutionary perspective from West Africa. Journal of Infectious Diseases, 218(3), 429-433. https://doi.org/10.1093/infdis/jiy029

The complex multi-host disease dynamics of schistosomiasis and Schistosoma spp., including the emergence of zoonotic parasite hybrids, remain largely unexplored in West Africa. We elucidated the role of wild small mammals as reservoir for zoonotic Sc... Read More about Rodents as natural hosts of zoonotic Schistosoma species and hybrids: an epidemiological and evolutionary perspective from West Africa.

Phenotypic and genotypic monitoring of Schistosoma mansoni in Tanzanian schoolchildren five years into a preventative chemotherapy national control programme (2017)
Journal Article
Gower, C. M., Gehre, F., Marques, S. R., Lamberton, P. H. L., Lwambo, N. J., & Webster, J. P. (2017). Phenotypic and genotypic monitoring of Schistosoma mansoni in Tanzanian schoolchildren five years into a preventative chemotherapy national control programme. https://doi.org/10.1186/s13071-017-2533-6

We conducted combined in vitro PZQ efficacy testing with population genetic analyses of S. mansoni collected from children from two schools in 2010, five years after the introduction of a National Control Programme. Children at one school had receive... Read More about Phenotypic and genotypic monitoring of Schistosoma mansoni in Tanzanian schoolchildren five years into a preventative chemotherapy national control programme.