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Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype (2019)
Journal Article
Lawson, J. S., Syme, H. M., Wheeler-Jones, C. P. D., & Elliott, J. (2019). Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype. Research in Veterinary Science, 127, 99-102. https://doi.org/10.1016/j.rvsc.2019.10.012

The Crandell-Rees Feline Kidney Cell (CRFK) is an immortalised cell line derived from the feline kidney that is utilised for the growth of certain vaccinal viruses. Confusion exists as to whether CRFK are epithelial or mesenchymal in phenotype. The a... Read More about Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype.

Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs (2019)
Journal Article
Pelander, L., Brunchault, V., Buffin-Meyer, B., Klein, J., Breuil, B., Zürbig, P., …Ljungvall, I. (2019). Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs. https://doi.org/10.1016/j.tvjl.2019.05.010

Chronic kidney disease (CKD) is clinically important in canine medicine. Current diagnostic tools lack sensitivity for detection of subclinical CKD. The aim of the present study was to evaluate urinary peptidome analysis for diagnosis of CKD in dogs.... Read More about Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs.

Physics of Animal Health: On the mechano-biology of hoof growth and form (2019)
Journal Article
Al-Agele, R., Paul, E., Taylor, S., Watson, C., Sturrock, C., Drakopoulos, M., …Rauch, C. (2019). Physics of Animal Health: On the mechano-biology of hoof growth and form. https://doi.org/10.1098/rsif.2019.0214

Global inequalities in economic access and agriculture productivity imply that a large number of developing countries rely on working equids for transport/agriculture/mining. Therefore, the understanding of hoof conditions/shape variations affecting... Read More about Physics of Animal Health: On the mechano-biology of hoof growth and form.

Chronic kidney disease in cats attending primary care practice in the UK: a VetCompassTM study (2019)
Journal Article
Conroy, M. C., Brodbelt, D. C., O'Neill, D. G., Chang, Y. M., & Elliott, J. (2019). Chronic kidney disease in cats attending primary care practice in the UK: a VetCompassTM study. Veterinary Record, 184(17), https://doi.org/10.1136/vr.105100

Chronic kidney disease (CKD) is a frequent diagnosis in cats attending primary care practice and the most frequent cause of death in cats aged over five years, yet there is limited published research for CKD in cats attending primary care practice. T... Read More about Chronic kidney disease in cats attending primary care practice in the UK: a VetCompassTM study.

Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dogs (2019)
Journal Article
Pelander, L., Häggström, J., Larsson, A., Syme, H. M., Elliott, J., Heiene, R., & Ljungvall, I. (2019). Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dogs. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15445

Effects of the long-term feeding of diets enriched with inorganic phosphorus on the adult feline kidney and phosphorus metabolism (2019)
Journal Article
Alexander, J., Stockman, J., Atwal, J., Butterwick, R., Colyer, A., Elliott, D., …Watson, P. (2019). Effects of the long-term feeding of diets enriched with inorganic phosphorus on the adult feline kidney and phosphorus metabolism. British Journal of Nutrition, 21, 1-21. https://doi.org/10.1017/S0007114518002751

Renal disease has a high incidence in cats, and some evidence implicates dietary P as well. To investigate this further, two studies in healthy adult cats were conducted. Study 1 (36 weeks) included forty-eight cats, stratified to control or test die... Read More about Effects of the long-term feeding of diets enriched with inorganic phosphorus on the adult feline kidney and phosphorus metabolism.

Survival after diagnosis of hypertension in cats attending primary care practice in the UK (2018)
Journal Article
Chang, Y. M., Brodbelt, D. C., Elliott, J., & Conroy, M. C. (2018). Survival after diagnosis of hypertension in cats attending primary care practice in the UK. Journal of Veterinary Internal Medicine, 32(6), 1846-1855. https://doi.org/10.1111/jvim.15307

Background: Hypertension is common in older cats. There is limited evidence for predictors of survival after diagnosis. Hypothesis/Objectives: Investigate blood pressure assessment (BPA) and hypertension diagnosis in cats attending UK primary care... Read More about Survival after diagnosis of hypertension in cats attending primary care practice in the UK.

The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1 (2018)
Journal Article
Lawson, J. S., Liu, H., Syme, H. M., Purcell, R., Wheeler-Jones, C. P. D., & Elliott, J. (2018). The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1. PLoS ONE, 13(8), e0202577. https://doi.org/10.1371/journal.pone.0202577

Chronic kidney disease (CKD) is common in both geriatric cats and aging humans, and is pathologically characterised by chronic tubulointerstitial inflammation and fibrosis in both species. Cats with CKD may represent a spontaneously occurring, non-ro... Read More about The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1.

Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies (2018)
Journal Article
Finding, E. J. T., Lawson, C., Elliott, J., Harris, P. A., & Menzies-Gow, N. J. (2018). Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies. Veterinary Immunology and Immunopathology, https://doi.org/10.1016/j.vetimm.2018.06.001

Microvesicles are small (up to 1 μm) vesicles found in plasma and other bodily fluids. They are recognised as part of the normal system of inter-cellular communication but altered numbers are also used as biomarkers of disease. Microvesicles have not... Read More about Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies.

Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies (2018)
Journal Article
Timpson, A., De Mestre, A. M., Elliott, J., Harris, P. A., Cheng, Z. R., Mirczuk, S. M., …Menzies-Gow, N. J. (2018). Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies. Journal of Equine Veterinary Science, https://doi.org/10.1016/j.jevs.2018.06.009

The aims of the study were to determine whether adipose tissue global gene expression (i) differs between never laminitic (NL) and previously laminitic (PL) ponies; (ii) is influenced by season and/or a diet designed to simulate spring grass and (iii... Read More about Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies.

Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1 (2018)
Journal Article
Lawson, J. S., Syme, H. M., Wheeler-Jones, C. P. D., & Elliott, J. (2018). Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1. BMC Veterinary Research, 14, 76. https://doi.org/10.1186/s12917-018-1387-2

Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell type predominantly responsible for the production of extra-cellular matrix in renal fibrosis... Read More about Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1.

Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease (2018)
Journal Article
Van Den Broek, D. H. N., Geddes, R. F., Williams, T. L., Chang, Y. M., Elliott, J., & Jepson, R. E. (2018). Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease. Journal of Veterinary Internal Medicine, 32(2), 727-735. https://doi.org/10.1111/jvim.15051

Background: Hypercalcemia is commonly associated with chronic kidney disease (CKD) in cats. Objectives: To explore the calcitonin response to naturally occurring ionized hypercalcemia in cats with azotemic CKD, and to assess the relationship of... Read More about Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease.

Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats (2018)
Journal Article
Geddes, R. F., Jepson, R. E., Forcada, Y., Elliott, J., & Syme, H. M. (2018). Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats. https://doi.org/10.1016/j.tvjl.2018.02.010

Feline chronic kidney disease (CKD) is associated with high variability in severity of CKD-mineral and bone disorder (CKD-MBD). The calcium sensing receptor (CaSR) regulates circulating parathyroid hormone (PTH) and calcium concentrations. Single nuc... Read More about Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats.

Plasma adrenocorticotropic hormone (ACTH) concentrations in ponies measured by two different assays suggests seasonal cross reactivity or interference (2018)
Journal Article
Knowles, E. J., Moreton-Clack, M. C., Shaw, S., Harris, P. A., Elliott, J., & Menzies-Gow, N. J. (2018). Plasma adrenocorticotropic hormone (ACTH) concentrations in ponies measured by two different assays suggests seasonal cross reactivity or interference. Equine Veterinary Journal, 50(5), 672-677. https://doi.org/10.1111/evj.12797