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Comparison of surgical indications and short- and long-term complications in 56 cats undergoing perineal, transpelvic or prepubic urethrostomy (2020)
Journal Article
Seneviratne, M., Stamenova, P., & Lee, K. (2020). Comparison of surgical indications and short- and long-term complications in 56 cats undergoing perineal, transpelvic or prepubic urethrostomy. Journal of Feline Medicine and Surgery, 1098612X2095903. https://doi.org/10.1177/1098612X20959032

Objectives
The aim of this study was to compare indications, complications and mortality rates for perineal urethrostomy (PU), transpelvic urethrostomy (TPU) and prepubic urethrostomy (PPU).

Methods
A retrospective review of, and follow-up owner... Read More about Comparison of surgical indications and short- and long-term complications in 56 cats undergoing perineal, transpelvic or prepubic urethrostomy.

The analysis of acetaminophen (paracetamol) and seven metabolites in rat, pig and human plasma by U(H)PLC–MS (2020)
Journal Article
Dargue, R., Grant, I., Nye, L. C., Nicholls, A., Dare, T., Stahl, S. H., Plumb, R. S., & Lee, K. C. L. (2020). The analysis of acetaminophen (paracetamol) and seven metabolites in rat, pig and human plasma by U(H)PLC–MS. Bioanalysis, 12(7), https://doi.org/10.4155/bio-2020-0015

A U(H)PLC–MS/MS method is described for the analysis of acetaminophen and its sulphate, glucuronide, glutathione, cysteinyl and N-acetylcysteinyl metabolites in plasma using stable isotope-labeled internal standards. P-Aminophenol glucuronide and 3-m... Read More about The analysis of acetaminophen (paracetamol) and seven metabolites in rat, pig and human plasma by U(H)PLC–MS.

Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure (2020)
Journal Article
Dargue, R., Zia, R., Lau, C., Nicholls, A. W., Dare, T. O., Lee, K. C. L., Jalan, R., Coen, M., & Wilson, I. D. (2020). Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure. Toxicological Sciences, https://doi.org/10.1093/toxsci/kfaa023

The metabolic fate, toxicity and effects on endogenous metabolism of paracetamol (acetaminophen, APAP) in 22 female Landrace cross large white pigs were evaluated in a model of acute liver failure (ALF). Anaesthetized pigs were initially dosed at 250... Read More about Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure.

Use of subcutaneous ureteral bypass systems as a bridge to definitive ureteral repair in a cat with bilateral ureteral ligation secondary to complicated ovariohysterectomy (2019)
Journal Article
Beer, A., Lipscomb, V. J., Rutherford, L., & Lee, K. C. L. (2019). Use of subcutaneous ureteral bypass systems as a bridge to definitive ureteral repair in a cat with bilateral ureteral ligation secondary to complicated ovariohysterectomy. https://doi.org/10.1136/vetreccr-2018-000758

A kitten presented with acute kidney injury, bilateral hydronephrosis and proximal hydroureter, three days following bilateral ureteral ligation, during a complicated ovariohysterectomy procedure. Clinical signs were anorexia, lethargy, weakness, hyp... Read More about Use of subcutaneous ureteral bypass systems as a bridge to definitive ureteral repair in a cat with bilateral ureteral ligation secondary to complicated ovariohysterectomy.

Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs (2017)
Journal Article
Lee, K. C. L., Baker, L., Mallett, S., Riddell, A., Chowdary, P., Alibhai, H. I. K., Chang, Y. M., Priestnall, S. L., Stanzani, G., Davies, N., Mookerjee, R., Jalan, R., & Agarwal, B. (2017). Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs. https://doi.org/10.1038/s41598-017-09508-3

Increases in prothrombin time (PT) and international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF), yet a wide heterogeneity in clotting abnormalities exists. This study defines evolution of coagulopathy in 10 pigs wi... Read More about Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs.

Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure (2015)
Journal Article
Baker, L. A., Lee, K. C. L., Jimenez, C. P., Alibhai, H. I. K., Chang, Y. M., Leckie, P. J., Mookerjee, R. P., Davies, N. A., Andreola, F., & Jalan, R. (2015). Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure. PLoS ONE, 10(5), https://doi.org/10.1371/journal.pone.0128076

Acute liver failure is a rare but catastrophic condition which can progress rapidly to multi-organ failure. Studies investigating the onset of individual organ injury such as the liver, kidneys and brain during the evolution of acute liver failure, a... Read More about Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure.

Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study (2015)
Journal Article
Lee, K. C. L., Baker, L. A., Stanzani, G., Alibhai, H. I. K., Chang, Y. M., Palacios, C. J., Leckie, P. J., Giordano, P., Priestnall, S. L., Antoine, D. J., Jenkins, R. E., Goldring, C. E., Park, B.-K., Andreola, F., Agarwal, B., Mookerjee, R. P., Davies, N. A., & Jalan, R. (2015). Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study. Journal of Hepatology, 63(3), 634-642. https://doi.org/10.1016/j.jhep.2015.04.020

Ornithine Phenylacetate targets alterations in the expression and activity of Glutamine Synthase and Glutaminase to reduce ammonia levels in bile duct ligated rats (2014)
Journal Article
Jover-Cobos, M., Noiret, L., Lee, K. C. L., Sharma, V., Habtesion, A., Romero-Gomez, M., Davies, N., & Jalan, R. (2014). Ornithine Phenylacetate targets alterations in the expression and activity of Glutamine Synthase and Glutaminase to reduce ammonia levels in bile duct ligated rats. Journal of Hepatology, 60(3), 545-553. https://doi.org/10.1016/j.jhep.2013.10.012

Background & Aims: In liver failure, ammonia homeostasis is dependent upon the function of the ammonia metabolising enzymes, glutamine synthetase (GS) and glutaminase (GA) but data about their protein expression and activity are lacking. The aims of... Read More about Ornithine Phenylacetate targets alterations in the expression and activity of Glutamine Synthase and Glutaminase to reduce ammonia levels in bile duct ligated rats.

A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival
Journal Article
Lee, K. C. L., Jimenez, C. P., Alibhai, H. I. K., Chang, Y. M., Leckie, P. J., Baker, L. A., Stanzani, G., Priestnall, S. L., Mookerjee, R. P., Jalan, F., & Davies, N. A. A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival. Liver International, 33(4), 544-551. https://doi.org/10.1111/liv.12042