Skip to main content

Research Repository

Advanced Search

All Outputs (123)

Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration (2014)
Journal Article
Kenward, H., Pelligand, L., & Elliott, J. (2014). Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration. Experimental Brain Research, 232(8), 2685-2697. https://doi.org/10.1007/s00221-014-3961-6

Cisplatin is a highly emetogenic cancer chemotherapy agent, which is often used to induce nausea and emesis in animal models. The cytotoxic properties of cisplatin also cause adverse events that negatively impact on animal welfare preventing repeated... Read More about Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration.

Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation (2014)
Journal Article
Pelligand, L., King, J. N., Hormazabal, V., Toutain, P. L., Elliott, J., & Lees, P. (2014). Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation. Journal of Veterinary Pharmacology and Therapeutics, 37(4), 354-366. https://doi.org/10.1111/jvp.12107

Robenacoxib and ketoprofen are acidic nonsteroidal anti‐inflammatory drugs (NSAIDs). Both are licensed for once daily administration in the cat, despite having short blood half‐lives. This study reports the pharmacokinetic/pharmacodynamic (PK/PD) mod... Read More about Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation.

Longitudinal left ventricular myocardial dysfunction assessed by 2D colour tissue Doppler imaging in a dog with systemic hypertension and severe arteriosclerosis
Journal Article
Nicolle, A. P., Sampedrano, C. C., Fontaine, J. J., Tessier-Vetzel, D., Goumi, V., Pelligand, L., Pouchelon, J. L., & Chetboul, V. Longitudinal left ventricular myocardial dysfunction assessed by 2D colour tissue Doppler imaging in a dog with systemic hypertension and severe arteriosclerosis. https://doi.org/10.1111/j.1439-0442.2004.00688.x

Side effects to systemic glucocorticoid therapy in dogs under primary veterinary care in the UK
Data
Elkholly, D. A., Brodbelt, D. C., Church, D. B., Pelligand, L., & O'Neill, D. G. Side effects to systemic glucocorticoid therapy in dogs under primary veterinary care in the UK. [Data]

"Side effects for SGC_Cases and non-cases_Treatment_Demographics" is a random sample of 3000 dogs under primary veterinary care that had systemic glucocorticoid treatment in 2013, taken from the VetCompass dataset. The data provide the demographic ch... Read More about Side effects to systemic glucocorticoid therapy in dogs under primary veterinary care in the UK.

Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed-effects to characterize and quantify variability in drug pharmacokinetics
Journal Article
Bon, C., Toutain, P. L., Concordet, D., Martin-Jimenez, T., Gehring, R., Smith, J., Pelligand, L., Martinez, M., Whittem, T., Riviere, J. E., & Mochel, J. P. Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed-effects to characterize and quantify variability in drug pharmacokinetics. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.12473

Pharmacokinetic/pharmacodynamic integration and modelling of amoxicillin for the calf pathogens Mannheimia haemolytica and Pasteurella multocida
Journal Article
Lees, P., Pelligand, L., Illambas, J., Potter, T. J., Lacroix, M., Rycroft, A. N., & Toutain, P. L. (in press). Pharmacokinetic/pharmacodynamic integration and modelling of amoxicillin for the calf pathogens Mannheimia haemolytica and Pasteurella multocida. Journal of Veterinary Pharmacology and Therapeutics, 38(5), 457-70. https://doi.org/10.1111/jvp.12207

The antimicrobial properties of amoxicillin were determined for the bovine respiratory tract pathogens, Mannheima haemolytica and Pasteurella multocida. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time‐kill cu... Read More about Pharmacokinetic/pharmacodynamic integration and modelling of amoxicillin for the calf pathogens Mannheimia haemolytica and Pasteurella multocida.