All Outputs (2)

Loss-of-function coding variants in the Ras of complex proteins/GTPase domain of leucine rich repeat kinase 2 (2025)
Journal Article
Butterfield, S., Herbst, S., & Lewis, P. (2025). Loss-of-function coding variants in the Ras of complex proteins/GTPase domain of leucine rich repeat kinase 2. Protein Science, 34(7), https://doi.org/10.1002/pro.70190

The LRRK2 gene is a key contributor to the genetic risk of Parkinson's disease, and a priority drug target for the disorder. Leucine Rich Repeat Kinase 2, the protein product of LRRK2, is a multidomain enzyme implicated in a range of cellular process... Read More about Loss-of-function coding variants in the Ras of complex proteins/GTPase domain of leucine rich repeat kinase 2.

Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis (2025)
Journal Article
Hardy, J., & Lewis, P. (2025). Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis. Molecular Neurodegeneration, 20(1), https://doi.org/10.1186/s13024-025-00847-8

While APP is largely neuonally expressed, A beta amyloid is largely produced by microglia as the clearance mechanisms for damaged membranes becomes overwhelmed.