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Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy (2018)
Journal Article
Amoasii, L., Hildyard, J. C. W., Li, H., Sanchez-Ortiz, E., Mireault, A., Caballero, D., …Olson, E. N. (2018). Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Science, 362(6410), 86-91. https://doi.org/10.1126/science.aau1549

Mutations in the gene encoding dystrophin, a protein that maintains muscle integrity and function, cause Duchenne muscular dystrophy (DMD). The deltaE50-MD dog model of DMD harbors a mutation corresponding to a mutational “hotspot” in the human DMD g... Read More about Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy.

Aldosterone-producing adrenocortical carcinoma with myxoid differentiation in a cat (2018)
Journal Article
Attipa, C., Beck, S., Lipscomb, V. J., English, K., Carvalho, S., Kiupel, M., …Peters, L. M. (2018). Aldosterone-producing adrenocortical carcinoma with myxoid differentiation in a cat. Veterinary Clinical Pathology, 47(4), 660-664. https://doi.org/10.1111/vcp.12658

A 10‐year‐old male neutered Persian cat was presented with an abdominal mass and history of weakness. Blood smear examination found marked elliptocytosis, and serum biochemical analysis revealed hypokalemia, hypochloremia, increased creatine kinase a... Read More about Aldosterone-producing adrenocortical carcinoma with myxoid differentiation in a cat.

The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization (2018)
Journal Article
Usherwood, J. R., Hubel, T. Y., Smith, B. J. H., Self Davies, Z. T., & Sobota, G. (2018). The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization. Journal of Biomechanics, 81, 12-21. https://doi.org/10.1016/j.jbiomech.2018.09.004

A simple model is developed to find vertical force profiles and stance durations that minimize either limb mechanical work or peak power demands during bipedal locomotion. The model predicts that work minimization is achieved with a symmetrical verti... Read More about The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization.

Cutaneous Botryomycosis in Two Pet Rabbits (2018)
Journal Article
Hedley, J., Stapleton, N., Muir, C., Priestnall, S. L., & Smith, K. (2018). Cutaneous Botryomycosis in Two Pet Rabbits. Journal of Exotic Pet Medicine, 28, 143-147. https://doi.org/10.1053/j.jepm.2018.01.005

A 5-year-old male neutered rabbit was presented for assessment of multiple abscesses, which had appeared suddenly over the ventrum, perineum and hindlimbs over the previous few days. Thirteen abscesses were surgically excised. Culture revealed Pseudo... Read More about Cutaneous Botryomycosis in Two Pet Rabbits.

Spatio-temporal patterns and agro-ecological risk factors for cutaneous and renal glomerular vasculopathy (Alabama Rot) in dogs in the UK (2018)
Journal Article
Stevens, K. B., Jepson, R. E., Holm, L. P., Walker, D. J., & Cardwell, J. M. (2018). Spatio-temporal patterns and agro-ecological risk factors for cutaneous and renal glomerular vasculopathy (Alabama Rot) in dogs in the UK. Veterinary Record, 183(16), 502. https://doi.org/10.1136/vr.104892

Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an incre... Read More about Spatio-temporal patterns and agro-ecological risk factors for cutaneous and renal glomerular vasculopathy (Alabama Rot) in dogs in the UK.

Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK (2018)
Journal Article
Stevens, K. B., O'Neill, D. G., Jepson, R. E., Holm, L. P., Walker, D. J., & Cardwell, J. M. (2018). Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK. Veterinary Record, 183(14), 448. https://doi.org/10.1136/vr.104891

Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an incre... Read More about Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK.

Bovine telomere dynamics and the association between telomere length and productive lifespan (2018)
Journal Article
Seeker, L. A., Ilska, J. J., Psifidi, A., Wilbourn, R., Underwood, S., Fairlie, J., …Banos, G. (2018). Bovine telomere dynamics and the association between telomere length and productive lifespan. https://doi.org/10.1038/s41598-018-31185-z

Average telomere length (TL) in blood cells has been shown to decline with age in a range of vertebrate species, and there is evidence that TL is a heritable trait associated with late-life health and mortality in humans. In non-human mammals, few st... Read More about Bovine telomere dynamics and the association between telomere length and productive lifespan.

The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1 (2018)
Journal Article
Lawson, J. S., Liu, H., Syme, H. M., Purcell, R., Wheeler-Jones, C. P. D., & Elliott, J. (2018). The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1. PLoS ONE, 13(8), e0202577. https://doi.org/10.1371/journal.pone.0202577

Chronic kidney disease (CKD) is common in both geriatric cats and aging humans, and is pathologically characterised by chronic tubulointerstitial inflammation and fibrosis in both species. Cats with CKD may represent a spontaneously occurring, non-ro... Read More about The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1.

Odontoameloblastoma with extensive chondroid matrix deposition in a guinea pig (2018)
Journal Article
Wong, H. E., Hedley, J., Stapleton, N., Murphy, B., & Priestnall, S. L. (2018). Odontoameloblastoma with extensive chondroid matrix deposition in a guinea pig. Journal of Veterinary Diagnostic Investigation, https://doi.org/10.1177/1040638718794784

Odontoameloblastomas (previously incorporated within ameloblastic odontomas) are matrix-producing odontogenic mixed tumors and are closely related in histologic appearance to the 2 other types of matrix-producing odontogenic mixed tumors: odontomas a... Read More about Odontoameloblastoma with extensive chondroid matrix deposition in a guinea pig.