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Odontoameloblastoma with extensive chondroid matrix deposition in a guinea pig

Wong, H E; Hedley, J; Stapleton, N; Murphy, B; Priestnall, S L

Authors

H E Wong

J Hedley

N Stapleton

B Murphy

S L Priestnall



Abstract

Odontoameloblastomas (previously incorporated within ameloblastic odontomas) are matrix-producing odontogenic mixed tumors and are closely related in histologic appearance to the 2 other types of matrix-producing odontogenic mixed tumors: odontomas and ameloblastic fibro-odontomas. The presence or absence of intralesional, induced non-neoplastic tissue must be accounted for in the diagnosis. Herein we describe a naturally occurring odontoameloblastoma with extensive chondroid cementum deposition in a guinea pig (Cavia porcellus). Microscopically, the mass featured palisading neoplastic odontogenic epithelium closely apposed to ribbons and rings of a pink dental matrix (dentinoid), alongside extensive sheets and aggregates of chondroid cementum. The final diagnosis was an odontoameloblastoma given the abundance of odontogenic epithelium in association with dentinoid but a paucity of pulp ectomesenchyme. Chondroid cementum is an expected anatomical feature of cavies, and its presence within the odontoameloblastoma was interpreted as a response of the ectomesenchyme of the dental follicle to the described neoplasm. Our case illustrates the inductive capabilities of odontoameloblastomas while highlighting species-specific anatomy that has resulted in a histologic appearance unique to cavies and provides imaging and histologic data to aid diagnosis of these challenging lesions.

Citation

Wong, H. E., Hedley, J., Stapleton, N., Murphy, B., & Priestnall, S. L. (2018). Odontoameloblastoma with extensive chondroid matrix deposition in a guinea pig. Journal of Veterinary Diagnostic Investigation, https://doi.org/10.1177/1040638718794784

Journal Article Type Article
Acceptance Date Aug 1, 2018
Publication Date Aug 22, 2018
Deposit Date Aug 25, 2018
Publicly Available Date Aug 28, 2018
Journal JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
Print ISSN 1040-6387
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1177/1040638718794784
Public URL https://rvc-repository.worktribe.com/output/1386194

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