Skip to main content

Research Repository

Advanced Search

All Outputs (2485)

Bird wings act as a suspension system that rejects gusts (2020)
Journal Article
Cheney, J. A., Stevenson, J. P. J., Durston, N. E., Song, J., Usherwood, J. R., Bomphrey, R. J., & Windsor, S. P. (2020). Bird wings act as a suspension system that rejects gusts. Proceedings of the Royal Society B: Biological Sciences, 287(1937), 20201748. https://doi.org/10.1098/rspb.2020.1748

Musculoskeletal systems cope with many environmental perturbations without neurological control. These passive preflex responses aid animals to move swiftly through complex terrain. Whether preflexes play a substantial role in animal flight is uncert... Read More about Bird wings act as a suspension system that rejects gusts.

Genome-wide analysis of the Firmicutes illuminates the diderm/monoderm transition. (2020)
Journal Article
Taib, N., Megrian, D., Witwinowski, J., Adam, P., Poppleton, D., Borrel, G., …Gribaldo, S. (2020). Genome-wide analysis of the Firmicutes illuminates the diderm/monoderm transition. Nature Ecology and Evolution, https://doi.org/10.1038/s41559-020-01299-7

The transition between cell envelopes with one membrane (Gram-positive or monoderm) and those with two membranes (Gram-negative or diderm) is a fundamental open question in the evolution of Bacteria. Evidence of the presence of two independent diderm... Read More about Genome-wide analysis of the Firmicutes illuminates the diderm/monoderm transition..

Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix (2020)
Journal Article
Zamboulis, D. E., Thorpe, C. T., Ashraf Kharaz, Y., Birch, H. L., Screen, H. R. C., & Clegg, P. D. (2020). Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix. eLife, 9,

Mature connective tissues demonstrate highly specialised properties, remarkably adapted to meet their functional requirements. Tissue adaptation to environmental cues can occur throughout life and poor adaptation commonly results in injury. However,... Read More about Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix.

Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways (2020)
Journal Article
Opdebeeck, B., Orriss, I., Neven, E., D’Haese, P. C., & Verhulst, A. (2020). Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways. International Journal of Molecular Sciences, 21(20), e7636

Arterial calcification, the deposition of calcium-phosphate crystals in the extracellular matrix, resembles physiological bone mineralization. It is well-known that extracellular nucleotides regulate bone homeostasis raising an emerging interest in t... Read More about Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways.

Phenotypic Spectrum of α-Dystroglycanopathies Associated With the c.919T>a Variant in the FKRP Gene in Humans and Mice (2020)
Journal Article
Brown, S. C., Fernandez-Fuente, M., Muntoni, F., & Vissing, J. (2020). Phenotypic Spectrum of α-Dystroglycanopathies Associated With the c.919T>a Variant in the FKRP Gene in Humans and Mice. Journal of Neuropathology and Experimental Neurology,

Abstract Mutations in the fukutin-related protein gene, FKRP, are the most frequent single cause of α-dystroglycanopathy. Rare FKRP mutations are clinically not well characterized. Here, we review the phenotype associated with the rare c.919T>A mu... Read More about Phenotypic Spectrum of α-Dystroglycanopathies Associated With the c.919T>a Variant in the FKRP Gene in Humans and Mice.

Animal Research beyond the Laboratory: Report from a Workshop on Places Other than Licensed Establishments (POLEs) in the UK (2020)
Journal Article
Palmer, A., Greenhough, B., Hobson-West, P., Message, R., Aegerter, J. N., Belshaw, Z., …Wolfensohn, S. (2020). Animal Research beyond the Laboratory: Report from a Workshop on Places Other than Licensed Establishments (POLEs) in the UK. Animals, 10(10), e1868

Research involving animals that occurs outside the laboratory raises an array of unique challenges. With regard to UK legislation, however, it receives only limited attention in terms of official guidelines, support, and statistics, which are unsurpr... Read More about Animal Research beyond the Laboratory: Report from a Workshop on Places Other than Licensed Establishments (POLEs) in the UK.

Walking in mud: Remarkable Pleistocene human trackways from White Sands National Park (New Mexico) (2020)
Journal Article
Bennett, M. R., Bustos, D., Odess, D., Urban, T. M., Lallensack, J. N., Budka, M., …Reynolds, S. C. (2020). Walking in mud: Remarkable Pleistocene human trackways from White Sands National Park (New Mexico). Quaternary Science Reviews, 249, 106610

Human tracks at White Sands National Park record more than one and a half kilometres of an out- and-return journey and form the longest Late Pleistocene-age double human trackway in the world. An adolescent or small adult female made two trips separa... Read More about Walking in mud: Remarkable Pleistocene human trackways from White Sands National Park (New Mexico).

Why are the fastest runners of intermediate size? Contrasting scaling of mechanical demands and muscle supply of work and power (2020)
Journal Article
Usherwood, J. R., & Gladman, N. W. (2020). Why are the fastest runners of intermediate size? Contrasting scaling of mechanical demands and muscle supply of work and power. Biology Letters, 16(10), 20200579

The fastest land animals are of intermediate size. Cheetah, antelope, greyhounds and racehorses have been measured running much faster than reported for elephants or elephant shrews. Can this be attributed to scaling of physical demands and explicit... Read More about Why are the fastest runners of intermediate size? Contrasting scaling of mechanical demands and muscle supply of work and power.

Initiation of a conserved trophectoderm program in human, cow and mouse embryos (2020)
Journal Article
Gerri, C., McCarthy, A., Alanis-Lobato, G., Demtschenko, A., Bruneau, A., Loubersac, S., …Niakan, K. K. (2020). Initiation of a conserved trophectoderm program in human, cow and mouse embryos. Nature, https://doi.org/10.1038/s41586-020-2759-x

Current understandings of cell specification in early mammalian pre-implantation development are based mainly on mouse studies. The first lineage differentiation event occurs at the morula stage, with outer cells initiating a trophectoderm (TE) place... Read More about Initiation of a conserved trophectoderm program in human, cow and mouse embryos.

3D hindlimb joint mobility of the stem-archosaur Euparkeria capensis with implications for postural evolution within Archosauria. (2020)
Journal Article
Demuth, O. E., Rayfield, E. J., & Hutchinson, J. R. (2020). 3D hindlimb joint mobility of the stem-archosaur Euparkeria capensis with implications for postural evolution within Archosauria. Scientific Reports, 10(1), 15357

Triassic archosaurs and stem-archosaurs show a remarkable disparity in their ankle and pelvis morphologies. However, the implications of these different morphologies for specific functions are still poorly understood. Here, we present the first quant... Read More about 3D hindlimb joint mobility of the stem-archosaur Euparkeria capensis with implications for postural evolution within Archosauria..

The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway (2020)
Journal Article
Faccenda, D., Gorini, G., Jones, A., Thornton, C., Baracca, A., Solaini, G., & Campanella, M. (2020). The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway

•IF1 regulates MCU-dependent mitochondrial Ca2+ uptake. •IF1 loss induces MCU upregulation through activation of the AMPK/CREB pathway. •OMA1 depletion restores physiological MCU levels and mitochondrial Ca2+ entry.

Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum (2020)
Journal Article
Regidor-Cerrillo, J., Xia, D., Jiménez-Pelayo, L., García-Sánchez, M., Collantes-Fernández, E., Randle, N., …Horcajo, P. (2020). Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum. Pathogens, 9(9), 749

Despite the importance of bovine neosporosis, relevant knowledge gaps remain concerning the pathogenic mechanisms of Neospora caninum. Infection of the placenta is a crucial event in the pathogenesis of the disease; however, very little is known abou... Read More about Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum.

Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by (2020)
Journal Article
Regidor-Cerrillo, J., Xia, D., Jiménez-Pelayo, L., García-Sánchez, M., Collantes-Fernández, E., Randle, N., …Horcajo, P. (2020). Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by. Pathogens, 9(9),

Despite the importance of bovine neosporosis, relevant knowledge gaps remain concerning the pathogenic mechanisms of . Infection of the placenta is a crucial event in the pathogenesis of the disease; however, very little is known about the relation... Read More about Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by.

Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration. (2020)
Journal Article
Faccenda, D., & Campanella, M. (2020). Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration. Journal of Neuroimmune Pharmacology,

Mitochondrial dysfunction occurs in most neurodegenerative diseases, contributing to both their onset and progression. A recent breakthrough unveiled that propagation of the inflammatory response and subsequent neuronal injury are also mediated extra... Read More about Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration..

Biomechanics of the mandible of Macaca mulatta during the power stroke of mastication: Loading, deformation, and strain regimes and the impact of food type (2020)
Journal Article
Panagiotopoulou, O., Iriarte-Diaz, J., Mehari Abraha, H., Taylor, A. B., Wilshin, S., Dechow, P. C., & Ross, C. F. (2020). Biomechanics of the mandible of Macaca mulatta during the power stroke of mastication: Loading, deformation, and strain regimes and the impact of food type. Journal of Human Evolution, 147, 102865. https://doi.org/10.1016/j.jhevol.2020.102865

Mandible morphology has yet to yield definitive information on primate diet, probably because of poor understanding of mandibular loading and strain regimes, and overreliance on simple beam models of mandibular mechanics. We used a finite element mod... Read More about Biomechanics of the mandible of Macaca mulatta during the power stroke of mastication: Loading, deformation, and strain regimes and the impact of food type.

Evolution of the patella and patelloid in marsupial mammals (2020)
Journal Article
Denyer, A. L., Regnault, S., & Hutchinson, J. R. (2020). Evolution of the patella and patelloid in marsupial mammals. PeerJ, 8, e9760

The musculoskeletal system of marsupial mammals has numerous unusual features beyond the pouch and epipubic bones. One example is the widespread absence or reduction (to a fibrous “patelloid”) of the patella (“kneecap”) sesamoid bone, but prior studi... Read More about Evolution of the patella and patelloid in marsupial mammals.

Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse (2020)
Journal Article
Shilton, C. A., Kahler, A., Davis, B. W., Crabtree, J. R., Crowhurst, J., McGladdery, A. J., …de Mestre, A. M. (2020). Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-69967-z

The first 8 weeks of pregnancy is a critical time, with the majority of pregnancy losses occurring during this period. Abnormal chromosome number (aneuploidy) is a common finding in human miscarriage, yet is rarely reported in domestic animals. Equin... Read More about Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse.

Artificial mass loading disrupts stable social order in pigeon dominance hierarchies (2020)
Journal Article
Portugal, S. J., Usherwood, J. R., White, C. R., Sankey, D. W. E., & Wilson, A. M. (2020). Artificial mass loading disrupts stable social order in pigeon dominance hierarchies. Biology Letters, 16(8), 20200468

Dominance hierarchies confer benefits to group members by decreasing the incidences of physical conflict, but may result in certain lower ranked individuals consistently missing out on access to resources. Here, we report a linear dominance hierarchy... Read More about Artificial mass loading disrupts stable social order in pigeon dominance hierarchies.