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FBS/BSA media concentration determines CCCP’s ability to depolarize mitochondria and activate PINK1-PRKN mitophagy (2019)
Journal Article
Soutar, M. P. M., Kempthorne, L., Annuario, E., Luft, C., Wray, S., Ketteler, R., Ludtmann, M. H. R., & Plun-Favreau, H. (2019). FBS/BSA media concentration determines CCCP’s ability to depolarize mitochondria and activate PINK1-PRKN mitophagy. Autophagy, https://doi.org/10.1080/15548627.2019.1603549

Mitochondrial quality control is essential for maintaining a healthy population of mitochondria. Two proteins associated with Parkinson disease, the kinase PINK1 and the E3 ubiquitin ligase PRKN, play a central role in the selective degradation of he... Read More about FBS/BSA media concentration determines CCCP’s ability to depolarize mitochondria and activate PINK1-PRKN mitophagy.

The architecture of cancellous bone in the hindlimb of moa (Aves: Dinornithiformes), with implications for stance and gait (2019)
Journal Article
Bishop, P. J., Scofield, R. P., & Hocknull, S. A. (2019). The architecture of cancellous bone in the hindlimb of moa (Aves: Dinornithiformes), with implications for stance and gait. https://doi.org/10.1080/03115518.2019.1594380

The extinct, flightless moa of New Zealand included some of the largest birds to have existed and possessed many distinguishing pelvic and hindlimb osteological features. These features may have influenced stance and gait in moa compared with extant... Read More about The architecture of cancellous bone in the hindlimb of moa (Aves: Dinornithiformes), with implications for stance and gait.

Polyunsaturated fatty acids influence offspring sex ratio in cows (2019)
Journal Article
Marei, W. F. A., Khalil, W. A., Pushpakumara, P. G. A., El-Harairy, M. A., Abo El-Atta, A. M. A., Wathes, D. C., & Fouladi-Nashta, A. A. (2019). Polyunsaturated fatty acids influence offspring sex ratio in cows. https://doi.org/10.1016/j.ijvsm.2018.01.006

Dietary polyunsaturated fatty acids (PUFAs) can influence fertility in farm animals. Some evidence in mice and sheep have suggested that PUFAs may influence offspring sex ratio, which may have significant value for cattle production. To test this hyp... Read More about Polyunsaturated fatty acids influence offspring sex ratio in cows.

Zebrafish as a model for kidney function and disease (2019)
Journal Article
Outtandy, P., Russell, C., Kleta, R., & Brockenhauer, D. (2019). Zebrafish as a model for kidney function and disease. Pediatric Nephrology, 34(5), 751-762. https://doi.org/10.1007/s00467-018-3921-7

Kidney disease is a global problem with around three million people diagnosed in the UK alone and the incidence is rising. Research is critical to develop better treatments. Animal models can help to better understand the pathophysiology behind the v... Read More about Zebrafish as a model for kidney function and disease.

The Role Of Fstl3 In Spermatogenesis: A Transcriptome Analysis (2019)
Presentation / Conference Contribution
Ballesteros, R., Xia, D., O'Shaughnessy, P., & Mukherjee, A. The Role Of Fstl3 In Spermatogenesis: A Transcriptome Analysis

Spermatogenesis in mammals depends on the function of Sertoli cells (SC). The total number of SC present in the testes is determined in the pre-pubertal stages of development. Activin, a TGFβ family ligand, regulates SC proliferation in the early pos... Read More about The Role Of Fstl3 In Spermatogenesis: A Transcriptome Analysis.

Germline-restricted chromosome (GRC) is widespread among songbirds (2019)
Journal Article
Torgasheva, A. A., Malinovskaya, L. P., Zadesenets, K. S., Karamysheva, T. V., Kizilova, E. A., Akberdina, E. A., Pristyazhnyuk, I. E., Shnaider, E. P., Volodkina, V. A., Saifitdinova, A. F., Galkina, S. A., Larkin, D. M., Rubtsov, N. B., & Borodin, P. M. (2019). Germline-restricted chromosome (GRC) is widespread among songbirds. https://doi.org/10.1073/pnas.1817373116

An unusual supernumerary chromosome has been reported for two related avian species, the zebra and Bengalese finches. This large, germline-restricted chromosome (GRC) is eliminated from somatic cells and spermatids and transmitted via oocytes only. I... Read More about Germline-restricted chromosome (GRC) is widespread among songbirds.

Faculty Perception of an Embedded Research Project in the Undergraduate Veterinary Curriculum (2019)
Journal Article
Cehrs, E., Pelligand, L., & Weller, R. (2019). Faculty Perception of an Embedded Research Project in the Undergraduate Veterinary Curriculum. Journal of Veterinary Medical Education,

In this article, we describe faculty’s perception of a research project embedded in the final year of the undergraduate veterinary curriculum and look at factors associated with overall perceptions of the project. We hypothesized that faculty would h... Read More about Faculty Perception of an Embedded Research Project in the Undergraduate Veterinary Curriculum.

Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method (2019)
Journal Article
Warboys, C. M., Ghim, M., & Weinberg, P. D. (2019). Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method. Atherosclerosis, 285, 170-177. https://doi.org/10.1016/j.atherosclerosis.2019.04.210

A striking feature of atherosclerosis is its highly non-uniform distribution within the arterial tree. This has been attributed to variation in the haemodynamic wall shear stress (WSS) experienced by endothelial cells, but the WSS characteristics tha... Read More about Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method.

Genome-wide association study for body weight in cattle populations from Siberia (2019)
Journal Article
Igoshin, A. V., Yudin, N. S., Belonogova, N. M., & Larkin, D. M. (2019). Genome-wide association study for body weight in cattle populations from Siberia. Animal Genetics, 50(3), 250-253. https://doi.org/10.1111/age.12786

Body weight is a complex trait in cattle associated with commonly used commercial breeding measurements related to growth. Although many quantitative trait loci (QTL) for body weight have been identified in cattle so far, searching for genetic determ... Read More about Genome-wide association study for body weight in cattle populations from Siberia.

Pretectal projections to the oculomotor cerebellum in hummingbirds ( Calypte anna ), zebra finches ( Taeniopygia guttata ), and pigeons ( Columba livia ) (2019)
Journal Article
Gaede, A. H., Gutierrez‐Ibanez, C., Armstrong, M. S., Altshuler, D. L., & Wylie, D. R. (2019). Pretectal projections to the oculomotor cerebellum in hummingbirds ( Calypte anna ), zebra finches ( Taeniopygia guttata ), and pigeons ( Columba livia ). Journal of Comparative Neurology, 527(16), 2644-2658. https://doi.org/10.1002/cne.24697

In birds, optic flow is processed by a retinal‐recipient nucleus in the pretectum, the nucleus lentiformis mesencephali (LM), which then projects to the cerebellum, a key site for sensorimotor integration. Previous studies have shown that the LM is h... Read More about Pretectal projections to the oculomotor cerebellum in hummingbirds ( Calypte anna ), zebra finches ( Taeniopygia guttata ), and pigeons ( Columba livia ).

Effect of oral administration of pioglitazone on follicular dynamics in Holstein dairy cows (2019)
Journal Article
Yousefi, A. R., Kohram, H., Zare Shahneh, A., Zamiri, M. J., Dirandeh, E., Kazemi Khoozani, M., Dadashpour Davachi, N., Zhandi, M., & Fouladi-Nashta, A. A. (2019). Effect of oral administration of pioglitazone on follicular dynamics in Holstein dairy cows. Livestock Science, 224, 50-56. https://doi.org/10.1016/j.livsci.2019.04.001

This study investigated the effects of oral administration of pioglitazone (PGT), a specific and synthetic ligand of peroxisome proliferator-activated receptors gamma (PPARγ), on follicular dynamics and corpus luteum (CL) functionality in dairy cows.... Read More about Effect of oral administration of pioglitazone on follicular dynamics in Holstein dairy cows.

Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling (2019)
Journal Article
Alyodawi, K., Vermeij, W. P., Omairi, S., Kretz, O., Hopkinson, M., Solagna, F., Joch, B., Brandt, R. M. C., Barnhoorn, S., Van Vliet, N., Ridwan, Y., Essers, J., Mitchell, R., Morash, T., Pasternack, A., Ritvos, O., Matsakas, A., Collins-Hooper, H., Huber, T. B., Hoeijmakers, J. H. J., & Patel, K. (2019). Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling. Journal of Cachexia, Sarcopenia and Muscle, https://doi.org/10.1002/jcsm.12404

Time lapse: A glimpse into prehistoric genomics (2019)
Journal Article
Griffin, D. K., Larkin, D. M., & O'Connor, R. E. (2019). Time lapse: A glimpse into prehistoric genomics. European Journal of Medical Genetics, https://doi.org/10.1016/j.ejmg.2019.03.004

For the purpose of this review, ‘time-lapse’ refers to the reconstruction of ancestral (in this case dinosaur) karyotypes using genome assemblies of extant species. Such reconstructions are only usually possible when genomes are assembled to ‘chromos... Read More about Time lapse: A glimpse into prehistoric genomics.

Vascular white matter lesions negatively correlate with brain metastases in malignant melanoma - results from a retrospective comparative analysis (2019)
Journal Article
Berk, B. A., Hering, K., Kortmann, R.-D., Hoffmann, K.-T., Ziemer, M., & Seidel, C. (2019). Vascular white matter lesions negatively correlate with brain metastases in malignant melanoma - results from a retrospective comparative analysis. Clinical Neurology and Neurosurgery, 180, 117-121. https://doi.org/10.1016/j.clineuro.2019.03.016

Brain metastasis (BM) is a major complication of different cancers. There is increasing evidence for influence of vascular factors on BM in patients with non-small cell lung cancer (NSCLC). It is not known if the same is true for other tumors that mi... Read More about Vascular white matter lesions negatively correlate with brain metastases in malignant melanoma - results from a retrospective comparative analysis.

Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations (2019)
Journal Article
Igoshin, A. V., Yurchenko, A. A., Belonogova, N. M., Petrovsky, D. V., Aitnazarov, R. B., Soloshenko, V. A., Yudin, N. S., & Larkin, D. M. (2019). Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations. BMC Genomics, 20(Suppl 1), https://doi.org/10.1186/s12863-019-0725-0

Design of new highly productive livestock breeds, well-adapted to local climatic conditions is one of the aims of modern agriculture and breeding. The genetics underlying economically important traits in cattle are widely studied, whereas our knowled... Read More about Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations.

Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation (2019)
Journal Article
Mahmoud, M., Evans, I. M., Mehta, V., Pellet-Many, C., Paliashvili, K., & Zachary, I. (2019). Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation. https://doi.org/10.1152/ajpcell.00405.2018

Neuropilin 1 (NRP1) is important for neuronal and cardiovascular development due to its role in conveying class 3 semaphorin and vascular endothelial growth factor signaling, respectively. NRP1 is expressed in smooth muscle cells (SMCs) and mediates... Read More about Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation.

Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs (2019)
Journal Article
Cuff, A. R., Daley, M. A., Michel, K. B., Allen, V. R., Lamas, L. P., Adami, C., Monticelli, P., Pelligand, L., & Hutchinson, J. R. (2019). Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs. Journal of Morphology, 280(5), 666-680. https://doi.org/10.1002/jmor.20973

Electromyography (EMG) is used to understand muscle activity patterns in animals. Understanding how much variation exists in muscle activity patterns in homologous muscles across animal clades during similar behaviours is important for evaluating the... Read More about Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs.

From the raw bar to the bench: Bivalves as models for human health (2019)
Journal Article
Fernández Robledo, J. A., Yadavalli, R., Allam, B., Pales Espinosa, E., Gerdol, M., Greco, S., Stevick, R. J., Gómez-Chiarri, M., Zhang, Y., Heil, C. A., Tracy, A. N., Bishop-Bailey, D., & Metzger, M. J. (2019). From the raw bar to the bench: Bivalves as models for human health. Developmental and Comparative Immunology, 92, 260-282. https://doi.org/10.1016/j.dci.2018.11.020

Bivalves, from raw oysters to steamed clams, are popular choices among seafood lovers and once limited to the coastal areas. The rapid growth of the aquaculture industry and improvement in the preservation and transport of seafood have enabled them t... Read More about From the raw bar to the bench: Bivalves as models for human health.