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Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations

Igoshin, A V; Yurchenko, A A; Belonogova, N M; Petrovsky, D V; Aitnazarov, R B; Soloshenko, V A; Yudin, N S; Larkin, D M

Authors

A V Igoshin

A A Yurchenko

N M Belonogova

D V Petrovsky

R B Aitnazarov

V A Soloshenko

N S Yudin

D M Larkin



Abstract

Design of new highly productive livestock breeds, well-adapted to local climatic conditions is one of the aims of modern agriculture and breeding. The genetics underlying economically important traits in cattle are widely studied, whereas our knowledge of the genetic mechanisms of adaptation to local environments is still scarce. To address this issue for cold climates we used an integrated approach for detecting genomic intervals related to body temperature maintenance under acute cold stress. Our approach combined genome-wide association studies (GWAS) and scans for signatures of selection applied to a cattle population (Hereford and Kazakh Whiteheaded beef breeds) bred in Siberia. We utilized the GGP HD150K DNA chip containing 139,376 single nucleotide polymorphism markers.

Citation

Igoshin, A. V., Yurchenko, A. A., Belonogova, N. M., Petrovsky, D. V., Aitnazarov, R. B., Soloshenko, V. A., …Larkin, D. M. (2019). Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations. BMC Genomics, 20(Suppl 1), https://doi.org/10.1186/s12863-019-0725-0

Journal Article Type Article
Acceptance Date Mar 12, 2019
Publication Date Mar 18, 2019
Deposit Date Mar 14, 2019
Publicly Available Date Mar 14, 2019
Journal BMC Genomics
Publisher BioMed Central
Peer Reviewed Peer Reviewed
Volume 20
Issue Suppl 1
DOI https://doi.org/10.1186/s12863-019-0725-0
Public URL https://rvc-repository.worktribe.com/output/1383136

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