Skip to main content

Research Repository

Advanced Search

All Outputs (2401)

Understanding the agility of running birds: Sensorimotor and mechanical factors in avian bipedal locomotion (2018)
Journal Article
Daley, M. A. (2018). Understanding the agility of running birds: Sensorimotor and mechanical factors in avian bipedal locomotion. Integrative and Comparative Biology, https://doi.org/10.1093/icb/icy058

Birds are a diverse and agile lineage of vertebrates that all use bipedal locomotion for at least part of their life. Thus birds provide a valuable opportunity to investigate how biomechanics and sensorimotor control are integrated for agile bipedal... Read More about Understanding the agility of running birds: Sensorimotor and mechanical factors in avian bipedal locomotion.

a-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease (2018)
Journal Article
Ludtmann, M. H. R., Angelova, P. R., Horrocks, M. H., Choi, M. L., Rodrigues, M., Baev, A. Y., …Gandhi, S. (2018). a-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease. Nature Communications, 9, 2293. https://doi.org/10.1038/s41467-018-04422-2

Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency. Here, we report that aggregation of monomer... Read More about a-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease.

Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates (2018)
Journal Article
Martin-Jimenez, R., Faccenda, D., Allen, E., Reichel, H. B., Arcos, L., Ferraina, C., …Campanella, M. (2018). Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates. https://doi.org/10.1038/s41419-018-0578-x

In vertebrates, mitochondria are tightly preserved energy producing organelles, which sustain nervous system development and function. The understanding of proteins that regulate their homoeostasis in complex animals is therefore critical and doing s... Read More about Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates.

Integrative transcriptome and proteome analyses define marked differences between Neospora caninum isolates throughout the tachyzoite lytic cycle (2018)
Journal Article
Horcajo, P., Xia, D., Randle, N., Collantes-Fernández, E., Wastling, J., Ortega-Mora, L. M., & Regidor-Cerrillo, J. (2018). Integrative transcriptome and proteome analyses define marked differences between Neospora caninum isolates throughout the tachyzoite lytic cycle. Journal of Proteomics, 180, 108-119. https://doi.org/10.1016/j.jprot.2017.11.007

Neospora caninum is one of the main causes of transmissible abortion in cattle. Intraspecific variations in virulence have been widely shown among N. caninum isolates. However, the molecular basis governing such variability have not been elucidated t... Read More about Integrative transcriptome and proteome analyses define marked differences between Neospora caninum isolates throughout the tachyzoite lytic cycle.

Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation (2018)
Journal Article
Martinez, M., Gehring, R., Mochel, J. P., Pade, D., & Pelligand, L. (2018). Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation. Journal of Veterinary Pharmacology and Therapeutics, 41(4), E-68. https://doi.org/10.1111/jvp.12666

During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the source... Read More about Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation.

Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age (2018)
Journal Article
Núñez, J. A., Goring, A., Javaheri, B., Razi, H., Gomez-Nicola, D., Pitsillides, A. A., …Clarkin, C. E. (2018). Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age. https://doi.org/10.22203/eCM.v035a20

Cortical bone is permeated by a system of pores, occupied by the blood supply and osteocytes. With ageing, bone mass reduction and disruption of the microstructure are associated with reduced vascular supply. Insight into the regulation of the blood... Read More about Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age.

Scaling of avian bipedal locomotion reveals independent effects of body mass and leg posture on gait (2018)
Journal Article
Daley, M. A., & Birn-Jeffery, A. V. (2018). Scaling of avian bipedal locomotion reveals independent effects of body mass and leg posture on gait. Journal of Experimental Biology, 221, https://doi.org/10.1242/jeb.152538

Birds provide an interesting opportunity to study the relationships between body size, limb morphology and bipedal locomotor function. Birds are ecologically diverse and span a large range of body size and limb proportions, yet all use their hindlimb... Read More about Scaling of avian bipedal locomotion reveals independent effects of body mass and leg posture on gait.

Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs (2018)
Journal Article
O'Connor, R. E., Romanov, M. N., Kiazim, L. G., Barrett, P. M., Farre Belmonte, M., Damas, J., …Griffin, D. K. (2018). Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs. Nature Communications, 9(1), 1883. https://doi.org/10.1038/s41467-018-04267-9

Genomic organisation of extinct lineages can be inferred from extant chromosome-level genome assemblies. Here, we apply bioinformatic and molecular cytogenetic approaches to determine the genomic structure of the diapsid common ancestor. We then infe... Read More about Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs.

A dynamic simulation of musculoskeletal function in the mouse hindlimb during trotting locomotion (2018)
Journal Article
Charles, J. P., Cappellari, I., & Hutchinson, J. R. (2018). A dynamic simulation of musculoskeletal function in the mouse hindlimb during trotting locomotion. Frontiers in Bioengineering and Biotechnology, 6(61), https://doi.org/10.3389/fbioe.2018.00061

Mice are often used as animal models of various human neuromuscular diseases, and analysis of these models often requires detailed gait analysis. However, little is known of the dynamics of the mouse musculoskeletal system during locomotion. In this... Read More about A dynamic simulation of musculoskeletal function in the mouse hindlimb during trotting locomotion.

The grazing gait, and implications of toppling table geometry for primate footfall sequences (2018)
Journal Article
Usherwood, J. R., & Smith, B. J. H. (2018). The grazing gait, and implications of toppling table geometry for primate footfall sequences. Biology Letters, 14(5), https://doi.org/10.1098/rsbl.2018.0137

Many medium and large herbivores locomote forwards very slowly and intermittently when grazing. While the footfall order during grazing is the same as for walking, the relative fore–hind timing—phasing—is quite different. Extended periods of static s... Read More about The grazing gait, and implications of toppling table geometry for primate footfall sequences.

Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A (2018)
Journal Article
De Ridder, D., Marino, S., Bishop, R. T., Renema, N., Chenu, C., Heymann, D., & Idris, A. I. (2018). Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A. https://doi.org/10.1038/s41598-018-25290-2

Semaphorin 3A (Sema3A), a secreted member of the Semaphorin family, increases osteoblast differentiation, stimulates bone formation and enhances fracture healing. Here, we report a previously unknown role of Sema3A in the regulation of ectopic bone f... Read More about Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A.

First anatomical network analysis of fore- and hindlimb musculoskeletal modularity in bonobos, common chimpanzees, and humans (2018)
Journal Article
Diogo, R., Molnar, J. L., Rolian, C., & Esteve-Altava, B. (2018). First anatomical network analysis of fore- and hindlimb musculoskeletal modularity in bonobos, common chimpanzees, and humans. https://doi.org/10.1038/s41598-018-25262-6

Studies of morphological integration and modularity, and of anatomical complexity in human evolution typically focus on skeletal tissues. Here we provide the first network analysis of the musculoskeletal anatomy of both the fore- and hindlimbs of the... Read More about First anatomical network analysis of fore- and hindlimb musculoskeletal modularity in bonobos, common chimpanzees, and humans.

Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response (2018)
Journal Article
Javaheri, B., Carriero, A., Wood, M., De Souza, R., Lee, P. D., Shefelbine, S., & Pitsillides, A. A. (2018). Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response. https://doi.org/10.1038/s41598-018-25084-6

Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in bone strength. It is unclear whether this is due to failure of osteocytes to sense strain, osteoblasts to form bone or insufficient mechanical stimul... Read More about Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response.

Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter (2018)
Journal Article
Read, J. E., Cabrera-Sharp, V., Kitscha, P., Cartwright, J. E., King, P. J., Fowkes, R. C., & De Mestre, A. M. (2018). Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter. Frontiers in Endocrinology, 9, https://doi.org/10.3389/fendo.2018.00195

Equine chorionic gonadotrophin (eCG) is a placental glycoprotein critical for early equine pregnancy and used therapeutically in a number of species to support reproductive activity. The factors in trophoblast that transcriptionally regulate eCGβ-sub... Read More about Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter.

Movement patterns and athletic performance of leopards in the Okavango Delta (2018)
Journal Article
Hubel, T. Y., Golabek, K. A., Rafiq, K., Weldon McNutt, J., & Wilson, A. M. (2018). Movement patterns and athletic performance of leopards in the Okavango Delta. Proceedings of the Royal Society B: Biological Sciences, 285(4), 1017-1027. https://doi.org/10.1098/rspb.2017.2622

Although leopards are the most widespread of all the big cats and are known for their adaptability, they are elusive and little is known in detail about their movement and hunting energetics. We used high-resolution GPS/IMU (inertial measurement unit... Read More about Movement patterns and athletic performance of leopards in the Okavango Delta.

Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling (2018)
Journal Article
Al-Rashed, F., Calay, D., Lang, M., Thornton, C., Bauer, A., Kiprianos, A., …Mason, J. C. (2018). Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling. https://doi.org/10.1038/s41598-018-24548-z

Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen. We investigated the hypothesis tha... Read More about Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling.