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Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows (2019)
Journal Article
Tombacz, K., Peters, L. M., Chang, Y. M., Steele, M., Werling, D., & Gibson, A. J. (2019). Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows. Journal of Dairy Science, 102(10), 9389-9395. https://doi.org/10.3168/jds.2019-16563

In periparturient dairy cows, immune suppression, resulting in decreased neutrophil numbers and function, leads to increased susceptibility to postpartum conditions such as mastitis, retained placenta, and metritis. Administration of polyethylene gly... Read More about Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows.

The specificity of phage testing for MAP — where might it fit into the diagnostic armoury? (2019)
Journal Article
Swift, B. M. C., & Rees, C. E. D. (2019). The specificity of phage testing for MAP — where might it fit into the diagnostic armoury?. Livestock, 24(4), https://doi.org/10.12968/live.2019.24.4.176

The current individual tools available for the diagnosis of Johne's disease are far from suitable to tackle this endemic disease. Culture, polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) tests, when used together can be... Read More about The specificity of phage testing for MAP — where might it fit into the diagnostic armoury?.

Neurophysiological correlates of stereotypic behaviour in a model carnivore species (2019)
Journal Article
Diez-Leon, M., Kitchenham, L., Duprey, R., Bailey, C. D. C., Choleris, E., Lewis, M., & Mason, G. (2019). Neurophysiological correlates of stereotypic behaviour in a model carnivore species. Behavioural Brain Research, 373, https://doi.org/10.1016/j.bbr.2019.112056

Stereotypic behaviour (SB) is common in animals housed in farm, zoo or laboratory conditions, including captive Carnivora (e.g. wild ursids and felids). Neurobiological data on housing-induced SBs come from four species (macaques, two rodent species,... Read More about Neurophysiological correlates of stereotypic behaviour in a model carnivore species.

Comparison of the effects of high and low milk-replacer feeding regimens on health and growth of crossbred dairy heifers (2019)
Journal Article
Johnson, K. F., Vinod Nair, R., & Wathes, D. C. (2019). Comparison of the effects of high and low milk-replacer feeding regimens on health and growth of crossbred dairy heifers. Animal Production Science, https://doi.org/10.1071/AN18432

This study compared performance relating to the growth and health of calves receiving one of two commercial feeding regimens: High or Low.

Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial (2019)
Journal Article
Sanchis-Mora, S., Chang, Y. M., Abeyesinghe, S. M., Fisher, A., Upton, N., Volk, H. A., & Pelligand, L. (2019). Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial. https://doi.org/10.1016/j.tvjl.2019.06.006

Pregabalin is the first-line treatment for neuropathic pain (NeP) in humans. Dogs with Chiari-like malformation and syringomyelia (CM/SM) associated with NeP could benefit from pregabalin. The aim of this study was to evaluate the efficacy of pregaba... Read More about Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial.

Canine Ependymoma: Diagnostic Criteria and Common Pitfalls (2019)
Journal Article
Miller, A. D., Koehler, J. W., Donovan, T. A., Stewart, J. E., Porter, B. F., Rissi, D. R., …Schulman, F. Y. (2019). Canine Ependymoma: Diagnostic Criteria and Common Pitfalls. Veterinary Pathology, 56(6), 860-867. https://doi.org/10.1177/0300985819859872

Reports of canine ependymoma are generally restricted to single case reports with tumor incidence estimated at 2% to 3% of primary central nervous system (CNS) tumors. While most commonly reported in the lateral ventricle, tumors can occur anywhere i... Read More about Canine Ependymoma: Diagnostic Criteria and Common Pitfalls.

Bilateral capital physeal dysplasia in a ferret (Mustela putorius furo) treated with femoral head ostectomy (2019)
Journal Article
Swaffield, M., Hedley, J., Stapleton, N., Priestnall, S. L., Suárez-Bonnet, A., & Baldrey, V. (2019). Bilateral capital physeal dysplasia in a ferret (Mustela putorius furo) treated with femoral head ostectomy. Journal of Exotic Pet Medicine, https://doi.org/10.1053/j.jepm.2019.05.003

A six-month-old male entire ferret presented for investigation of atraumatic bilateral pelvic limb lameness. Radiographic and subsequent histopathological assessment of the femoral heads following bilateral femoral head ostectomy was consistent with... Read More about Bilateral capital physeal dysplasia in a ferret (Mustela putorius furo) treated with femoral head ostectomy.

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases (2019)
Journal Article
Singhania, A., Graham, C. M., Gabryšová, L., Moreira-Teixeira, L., Stavropoulos, E., Pitt, J. M., …O’Garra, A. (2019). Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases. Nature Communications, 10, https://doi.org/10.1038/s41467-019-10601-6

Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation... Read More about Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.

Managed trade: The US–Mexico sugar suspension agreements (2019)
Journal Article
Carter, C. A., Saitone, T. L., & Schaefer, K. A. (2019). Managed trade: The US–Mexico sugar suspension agreements. Canadian Journal of Economics, https://doi.org/10.1111/caje.12393

Under the 1994 North American Free Trade Agreement, Mexican sugar producers were ultimately granted free access to the US sugar market, while all other suppliers, including US refiners, were subject to supply quotas. Following a surge in imports of M... Read More about Managed trade: The US–Mexico sugar suspension agreements.

Pathotyping the Zoonotic Pathogen Streptococcus suis: Novel Genetic Markers To Differentiate Invasive Disease-Associated Isolates from Non-Disease-Associated Isolates from England and Wales (2019)
Journal Article
Wileman, T. M., Weinert, L. A., Howell, K. J., Wang, J., Peters, S. E., Williamson, S. M., …Tucker, A. W. (2019). Pathotyping the Zoonotic Pathogen Streptococcus suis: Novel Genetic Markers To Differentiate Invasive Disease-Associated Isolates from Non-Disease-Associated Isolates from England and Wales. Journal of Clinical Microbiology, 57, e01712. https://doi.org/10.1128/JCM.01712-18

Streptococcus suis is one of the most important zoonotic bacterial pathogens of pigs, causing significant economic losses to the global swine industry. S. suis is also a very successful colonizer of mucosal surfaces, and commensal strains can be foun... Read More about Pathotyping the Zoonotic Pathogen Streptococcus suis: Novel Genetic Markers To Differentiate Invasive Disease-Associated Isolates from Non-Disease-Associated Isolates from England and Wales.

A novel, high-sensitivity, bacteriophage-based assay identifies low level Mycobacterium tuberculosis bacteraemia in immunocompetent patients with active and incipient tuberculosis (2019)
Journal Article
Verma, R., Swift, B. M. C., Handley-Hartill, W., Lee, J. K., Woltmann, G., Rees, C. E. D., & Haldar, P. (2019). A novel, high-sensitivity, bacteriophage-based assay identifies low level Mycobacterium tuberculosis bacteraemia in immunocompetent patients with active and incipient tuberculosis. Clinical Infectious Diseases, 70(5), 933-936. https://doi.org/10.1093/cid/ciz548

Haematogenous dissemination of M. tuberculosis (Mtb) is critical to pathogenesis of progressive tuberculous infection in animal models. Using a novel phage-based blood assay, we report the first concordant evidence in well-characterised immunocompete... Read More about A novel, high-sensitivity, bacteriophage-based assay identifies low level Mycobacterium tuberculosis bacteraemia in immunocompetent patients with active and incipient tuberculosis.

Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome (2019)
Journal Article
Pittaway, R., Dobromylskyj, M. J., Erles, K., Pittaway, C. E., Suárez-Bonnet, A., Chang, Y. M., & Priestnall, S. L. (2019). Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome. Veterinary Pathology, 56(6), 868-877. https://doi.org/10.1177/0300985819854435

Nonocular melanocytic neoplasia is considered uncommon in cats yet is routinely encountered in diagnostic pathology and recognized to exhibit a wide variation in biological behavior. Accurate prediction of clinical outcomes is challenging with no wid... Read More about Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome.

Opportunistic bacteria and mass mortality in ungulates: lessons from an extreme event (2019)
Journal Article
Robinson, S., Milner-Gulland, E. J., Grachev, Y., Salemgareyev, A., Orynbayev, M., Morgan, E., …Kock, R. A. (2019). Opportunistic bacteria and mass mortality in ungulates: lessons from an extreme event. Ecosphere, 10(6), e02671. https://doi.org/10.1002/ecs2.2671

Mass mortality events in wildlife are a growing concern. Under conditions of rapid global change, opportunistic responses in bacterial commensals, triggered by environmental stressors, may be increasingly implicated in die‐offs. In 2015, over 200,000... Read More about Opportunistic bacteria and mass mortality in ungulates: lessons from an extreme event.

Antimicrobial Residues in Chicken and Fish, Chittagong, Bangladesh (2019)
Journal Article
Ferdous, J., Bradshaw, A., Islam, S. K. M. A., Zamil, S., Islam, A., Ahad, A., …Hoque, M. A. (2019). Antimicrobial Residues in Chicken and Fish, Chittagong, Bangladesh. EcoHealth, https://doi.org/10.1007/s10393-019-01430-6

A cross-sectional observation and an intervention study were conducted in Chittagong, Bangladesh in 2015 to assess the status of antimicrobial residues in chicken and fish. The samples were tested for selected antimicrobials (amoxicillin, ciprofloxac... Read More about Antimicrobial Residues in Chicken and Fish, Chittagong, Bangladesh.

VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle (2019)
Journal Article
Toutain, P., Sidhu, P. K., Lees, P., Rassouli, A., & Pelligand, L. (2019). VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle. Frontiers in Microbiology, 10(1310), https://doi.org/10.3389/fmicb.2019.01310

The PK/PD cut-off (PK/PDCO ) value of florfenicol for calf pathogens was determined for long acting formulations (MSD Nuflor® and a bioequivalent generic product). PK/PDCO is one of the three MICs considered by VetCAST, a sub-committee of the Europea... Read More about VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle.

Disorders of Bulldogs under primary veterinary care in the UK in 2013 (2019)
Journal Article
O'Neill, D. G., Skipper, A. M., Kadhim, J., Church, D. B., Brodbelt, D. C., & Packer, R. M. A. (2019). Disorders of Bulldogs under primary veterinary care in the UK in 2013. PLoS ONE, 14(6), e0217928. https://doi.org/10.1371/journal.pone.0217928

The Bulldog is a popular companion breed in the UK despite widely reported disease predispositions. This study aimed to characterise the demography, mortality and common disorders of Bulldogs under veterinary care in the UK during 2013. VetCompass co... Read More about Disorders of Bulldogs under primary veterinary care in the UK in 2013.

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites (2019)
Journal Article
Knuepfer, E., Wright, K. E., Prajapati, S. K., Rawlinson, T. A., Mohring, F., Koch, M., …Holder, A. A. (2019). Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites. PLoS Pathogens, 15(6), e1007809. https://doi.org/10.1371/journal.ppat.1007809

Malaria is caused by Plasmodium parasites, which invade and replicate in erythrocytes. For Plasmodium falciparum, the major cause of severe malaria in humans, a heterotrimeric complex comprised of the secreted parasite proteins, PfCyRPA, PfRIPR and P... Read More about Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.

Identifying hotspots for antibiotic resistance emergence and selection, and elucidating pathways to human exposure: Application of a systems-thinking approach to aquaculture systems (2019)
Journal Article
Brunton, L. A., Desbois, A. P., Garza, M., Wieland, B., Mohan, C. V., Haesler, B., …Guitian, J. (2019). Identifying hotspots for antibiotic resistance emergence and selection, and elucidating pathways to human exposure: Application of a systems-thinking approach to aquaculture systems. Science of the Total Environment, 687, 1344-1356. https://doi.org/10.1016/j.scitotenv.2019.06.134

Aquaculture systems are highly complex, dynamic and interconnected systems influenced by environmental, biological, cultural, socio-economic and human behavioural factors. Intensification of aquaculture production is likely to drive indiscriminate us... Read More about Identifying hotspots for antibiotic resistance emergence and selection, and elucidating pathways to human exposure: Application of a systems-thinking approach to aquaculture systems.

Risk of Lameness in Dairy Cows with Paratuberculosis Infection (2019)
Journal Article
Smith, J., & Van Winden, S. C. L. (2019). Risk of Lameness in Dairy Cows with Paratuberculosis Infection. Animals, 9(6), 339. https://doi.org/10.3390/ani9060339

Johne’s disease (JD) is an important disease affecting the UK dairy industry, as is cattle lameness. An association between JD and lameness has been suggested; however, little evidence exists to support this. The purpose of this study was to determin... Read More about Risk of Lameness in Dairy Cows with Paratuberculosis Infection.