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A novel, high-sensitivity, bacteriophage-based assay identifies low level Mycobacterium tuberculosis bacteraemia in immunocompetent patients with active and incipient tuberculosis

Verma, R; Swift, B M C; Handley-Hartill, W; Lee, J K; Woltmann, G; Rees, C E D; Haldar, P

Authors

R Verma

B M C Swift

W Handley-Hartill

J K Lee

G Woltmann

C E D Rees

P Haldar



Abstract

Haematogenous dissemination of M. tuberculosis (Mtb) is critical to pathogenesis of progressive tuberculous infection in animal models. Using a novel phage-based blood assay, we report the first concordant evidence in well-characterised immunocompetent human cohorts, demonstrating associations of Mtb bacteraemia with progressive phenotypes of latent infection and active pulmonary TB respectively.

Citation

Verma, R., Swift, B. M. C., Handley-Hartill, W., Lee, J. K., Woltmann, G., Rees, C. E. D., & Haldar, P. (2019). A novel, high-sensitivity, bacteriophage-based assay identifies low level Mycobacterium tuberculosis bacteraemia in immunocompetent patients with active and incipient tuberculosis. Clinical Infectious Diseases, 70(5), 933-936. https://doi.org/10.1093/cid/ciz548

Journal Article Type Article
Acceptance Date Jun 11, 2019
Publication Date Jun 22, 2019
Deposit Date Jul 5, 2019
Publicly Available Date Jun 22, 2020
Journal CLINICAL INFECTIOUS DISEASES
Print ISSN 1058-4838
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 70
Issue 5
Pages 933-936
DOI https://doi.org/10.1093/cid/ciz548
Public URL https://rvc-repository.worktribe.com/output/1381610

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