A novel, high-sensitivity, bacteriophage-based assay identifies low level Mycobacterium tuberculosis bacteraemia in immunocompetent patients with active and incipient tuberculosis

Verma, R; Swift, B M C; Handley-Hartill, W; Lee, J K; Woltmann, G; Rees, C E D; Haldar, P

Abstract

Haematogenous dissemination of M. tuberculosis (Mtb) is critical to pathogenesis of progressive tuberculous infection in animal models. Using a novel phage-based blood assay, we report the first concordant evidence in well-characterised immunocompetent human cohorts, demonstrating associations of Mtb bacteraemia with progressive phenotypes of latent infection and active pulmonary TB respectively.

Citation

Verma, R., Swift, B. M. C., Handley-Hartill, W., Lee, J. K., Woltmann, G., Rees, C. E. D., & Haldar, P. (2019). A novel, high-sensitivity, bacteriophage-based assay identifies low level Mycobacterium tuberculosis bacteraemia in immunocompetent patients with active and incipient tuberculosis. Clinical Infectious Diseases, 70(5), 933-936. https://doi.org/10.1093/cid/ciz548

• Journal Article Type: Article
• Acceptance Date: Jun 11, 2019
• Publication Date: Jun 22, 2019
• Deposit Date: Jul 5, 2019
• Publicly Available Date: Jun 22, 2020
• Journal: CLINICAL INFECTIOUS DISEASES
• Print ISSN: 1058-4838
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 70
• Issue: 5
• Pages: 933-936
• DOI: https://doi.org/10.1093/cid/ciz548
• Public URL: https://rvc-repository.worktribe.com/output/1381610