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All Outputs (202)

Breed and conformational predispositions for prolapsed nictitating membrane gland (PNMG) in dogs in the UK: A VetCompass study (2022)
Journal Article
O'Neill, D., Yahui, Y., Roser, T. P., Dave C., B., David B., C., Camilla, P., & Minn, M. (2022). Breed and conformational predispositions for prolapsed nictitating membrane gland (PNMG) in dogs in the UK: A VetCompass study. (Con)textos Linguísticos, 17(1), https://doi.org/10.1371/journal.pone.0260538

Background
Prolapsed nictitating membrane gland (PNMG) is the most common disorder of the third eyelid in dogs. However, the epidemiology of PNMG in the wider dog population remains understudied.

Methods
Using de-identified clinical data from th... Read More about Breed and conformational predispositions for prolapsed nictitating membrane gland (PNMG) in dogs in the UK: A VetCompass study.

Veterinary drug therapies used for undesirable behaviours in UK dogs under primary veterinary care (2022)
Journal Article
Pegram, C., Craven, A., Packer, R., Jarvis, S., McGreevy, P., Warnes, C., Church, D., Brodbelt, D., & O'Neill, D. (in press). Veterinary drug therapies used for undesirable behaviours in UK dogs under primary veterinary care. PLoS ONE, 17, https://doi.org/10.1371/journal.pone.0261139

Undesirable behaviours (UBs) in dogs are common and important issues with serious potential welfare consequences for both the dogs and their owners. This study aimed to investigate the usage of drug therapy for UBs in dogs and assess demographic risk... Read More about Veterinary drug therapies used for undesirable behaviours in UK dogs under primary veterinary care.

A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats (2021)
Journal Article
Catchpole, B., Forcada, Y., Boursnell, M., & Church, D. (2021). A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats. PLoS ONE, https://doi.org/10.1371/journal.pone.0259939

Diabetes mellitus (DM) is a common feline endocrinopathy, which is similar to human type 2 diabetes (T2DM) in terms of its pathophysiology. T2DM occurs due to peripheral insulin resistance and/or β-cell dysfunction. Several studies have identified ge... Read More about A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats.

Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK (2021)
Journal Article
Pegram, C., Raffan, E., White, E., Ashworth, A., Brodbelt, D., Church, D., & O'Neill, D. (2021). Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13325

Objectives: To evaluate the prevalence and risk factors for overweight status in dogs under primary veterinary care in the UK.
Methods: A retrospective study design was used to estimate the one-year (2016) period prevalence of overweight status. The... Read More about Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK.

Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors (2021)
Journal Article
Mirczuk, S., Scudder, C., Read, J., Crossley, V., Regan, J., Richardson, K., Simbi, B., Mcardle, C., Church, D., Fenn, J., Kenny, P., Volk, H., Wheeler-Jones, C., Korbonits, M., Niessen, S., Mcgonnell, I., & Fowkes, R. (2021). Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors. International Journal of Molecular Sciences, -. https://doi.org/10.3390/ijms22031076

Patients harbouring mutations in genes encoding C-type natriuretic peptide (CNP; NPPC) or its receptor guanylyl cyclase B (GC-B, NPR2) suffer from severe growth phenotypes; loss-of-function mutations cause achondroplasia, whereas gain-of-function mut... Read More about Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors.

Hypoadrenocorticism in dogs under UK primary veterinary care: frequency, clinical approaches and risk factors (2020)
Journal Article
Schofield, I., Woolhead, V., Johnson, A., Brodbelt, D. C., Church, D. B., & O'Neill, D. G. (2020). Hypoadrenocorticism in dogs under UK primary veterinary care: frequency, clinical approaches and risk factors. Journal of Small Animal Practice, 1-8. https://doi.org/10.1111/jsap.13285

Objectives: To estimate the frequency, clinical approaches and risk factors of hypoadrenocorticism in dogs under UK primary veterinary care. Materials and MethOds: Dogs diagnosed with hypoadrenocorticism were identified from the UK VetCompass™ progr... Read More about Hypoadrenocorticism in dogs under UK primary veterinary care: frequency, clinical approaches and risk factors.

Vestibular disease in dogs under UK primary veterinary care: Epidemiology and clinical management (2020)
Journal Article
Radulescu, S. M., Humm, K., Eramanis, L. M., Volk, H. A., Church, D. B., Brodbelt, D., & O'Neill, D. G. (2020). Vestibular disease in dogs under UK primary veterinary care: Epidemiology and clinical management. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15869

Background

Vestibular disease (VD), central or peripheral, can be a dramatic primary‐care presentation. Current literature describes mostly dogs examined in referral centers.

Hypothesis/Objectives

Describe the prevalence, presentation, clini... Read More about Vestibular disease in dogs under UK primary veterinary care: Epidemiology and clinical management.

Vestibular disease in dogs under UK primary veterinary care: Epidemiology and clinical management (2020)
Journal Article
Radulescu, S. M., Humm, K., Eramanis, L. M., Volk, H. A., Church, D. B., Brodbelt, D., & O'Neill, D. G. (2020). Vestibular disease in dogs under UK primary veterinary care: Epidemiology and clinical management. Journal of Veterinary Internal Medicine, 34(5), 1993-2004. https://doi.org/10.1111/jvim.15869

Background

Vestibular disease (VD), central or peripheral, can be a dramatic primary‐care presentation. Current literature describes mostly dogs examined in referral centers.

Hypothesis/Objectives

Describe the prevalence, presentation, clini... Read More about Vestibular disease in dogs under UK primary veterinary care: Epidemiology and clinical management.

Clinical management of lipomas in dogs under primary care in the UK (2020)
Journal Article
Pegram, C. L., Rutherford, L., Corah, C., Church, D. B., Brodbelt, D. C., & O'Neill, D. G. (2020). Clinical management of lipomas in dogs under primary care in the UK. Veterinary Record, vetrec-2019

Lipomas are relatively common and biologically benign masses of mesenchymal origin consisting of adipocytes. This study reports benchmark data on the clinical management and outcomes of lipomas in dogs under UK primary veterinary care. The study used... Read More about Clinical management of lipomas in dogs under primary care in the UK.

Diabetes mellitus in dogs attending UK primary-care practices: frequency, risk factors and survival (2020)
Journal Article
Heeley, A., O’Neill, D., Davison, L., Church, D., Corless, E., & Brodbelt, D. (2020). Diabetes mellitus in dogs attending UK primary-care practices: frequency, risk factors and survival. Canine Medicine and Genetics, 7(1), https://doi.org/10.1186/s40575-020-00087-7

Background: Diabetes mellitus (DM) is an important endocrine disorder of dogs. The objectives of this study were to estimate prevalence and incidence of DM in dogs, and to explore risk factors for DM and the survival of DM cases in primary-care clini... Read More about Diabetes mellitus in dogs attending UK primary-care practices: frequency, risk factors and survival.

Epidemiology and clinical management of elbow joint disease in dogs under primary veterinary care in the UK (2020)
Journal Article
O'Neill, D. G., Brodbelt, D. C., Hodge, R., Church, D. B., & Meeson, R. L. (2020). Epidemiology and clinical management of elbow joint disease in dogs under primary veterinary care in the UK. https://doi.org/10.1186/s40575-020-0080-5

Conditions affecting the elbow joint are a common cause of lameness in dogs. Primary-care veterinary clinical data are now recognised as a valuable research resource. Using data from the VetCompass Programme, this study aimed to report the frequency... Read More about Epidemiology and clinical management of elbow joint disease in dogs under primary veterinary care in the UK.

Demography and commonly recorded clinical conditions of Chihuahuas under primary veterinary care in the UK in 2016 (2020)
Journal Article
O’Neill, D. G., Packer, R. M. A., Lobb, M., Church, D. B., Brodbelt, D. C., & Pegram, C. (2020). Demography and commonly recorded clinical conditions of Chihuahuas under primary veterinary care in the UK in 2016. BMC Veterinary Research, 16(42), https://doi.org/10.1186/s12917-020-2258-1

The Chihuahua, the world’s smallest dog breed, is a popular breed in the UK today. The VetCompass™ Programme collates de-identified clinical records from primary-care veterinary practices in the UK for epidemiological research. This study aimed to ch... Read More about Demography and commonly recorded clinical conditions of Chihuahuas under primary veterinary care in the UK in 2016.

Juvenile-onset and adult-onset demodicosis in dogs in the UK: prevalence and breed associations (2019)
Journal Article
O'Neill, D. G., Turgoose, E., Church, D. B., Brodbelt, D. C., & Hendricks, A. (2019). Juvenile-onset and adult-onset demodicosis in dogs in the UK: prevalence and breed associations. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13067

Objectives
To explore epidemiological features of demodicosis relevant to UK veterinary general practitioners. Breed risk factors were proposed as distinct between juvenile‐onset and adult‐onset disease.

Materials and Methods
The study used anon... Read More about Juvenile-onset and adult-onset demodicosis in dogs in the UK: prevalence and breed associations.

Persian cats under first opinion veterinary care in the UK: demography, mortality and disorders (2019)
Journal Article
O'Neill, D. G., Romans, C., Brodbelt, D. C., Church, D. B., Cerna, P., & Gunn-Moore, D. A. (2019). Persian cats under first opinion veterinary care in the UK: demography, mortality and disorders. https://doi.org/10.1038/s41598-019-49317-4

Persian cats are a popular cat breed worldwide, and especially in the US, Europe and Asia. This study aimed to describe the demography, common disorders and mortality in Persians under general practice veterinary care in 2013 in the UK. The study pop... Read More about Persian cats under first opinion veterinary care in the UK: demography, mortality and disorders.